| Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2–p53 inhibitor in clinical development D Sun, Z Li, Y Rew, M Gribble, MD Bartberger, HP Beck, J Canon, A Chen, ... Journal of medicinal chemistry 57 (4), 1454-1472, 2014 | 329 | 2014 |
| Structure-based design of novel inhibitors of the MDM2–p53 interaction Y Rew, D Sun, F Gonzalez-Lopez De Turiso, MD Bartberger, HP Beck, ... Journal of medicinal chemistry 55 (11), 4936-4954, 2012 | 202 | 2012 |
| Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity S Walker, L Chen, Y Hu, Y Rew, D Shin, DL Boger Chemical reviews 105 (2), 449-476, 2005 | 157 | 2005 |
| Synthesis and Biological Activities of Cyclic Lanthionine Enkephalin Analogues: δ-Opioid Receptor Selective Ligands Y Rew, S Malkmus, C Svensson, TL Yaksh, NN Chung, PW Schiller, ... Journal of medicinal chemistry 45 (17), 3746-3754, 2002 | 128 | 2002 |
| Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer Y Rew, D Sun Journal of medicinal chemistry 57 (15), 6332-6341, 2014 | 104 | 2014 |
| Selective and potent morpholinone inhibitors of the MDM2–p53 protein–protein interaction AZ Gonzalez, J Eksterowicz, MD Bartberger, HP Beck, J Canon, A Chen, ... Journal of medicinal chemistry 57 (6), 2472-2488, 2014 | 101 | 2014 |
| Rational design and binding mode duality of MDM2–p53 inhibitors F Gonzalez-Lopez de Turiso, D Sun, Y Rew, MD Bartberger, HP Beck, ... Journal of medicinal chemistry 56 (10), 4053-4070, 2013 | 94 | 2013 |
| Ordering of the N-terminus of human MDM2 by small molecule inhibitors K Michelsen, JB Jordan, J Lewis, AM Long, E Yang, Y Rew, J Zhou, ... Journal of the American Chemical Society 134 (41), 17059-17067, 2012 | 87 | 2012 |
| Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2–p53 interaction Y Rew, D Sun, X Yan, HP Beck, J Canon, A Chen, J Duquette, ... Journal of Medicinal Chemistry 57 (24), 10499-10511, 2014 | 76 | 2014 |
| Cancer-related bone pain is attenuated by a systemically available δ-opioid receptor agonist J Brainin-Mattos, ND Smith, S Malkmus, Y Rew, M Goodman, J Taulane, ... PAIN® 122 (1-2), 174-181, 2006 | 74 | 2006 |
| Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres AZ Gonzalez, Z Li, HP Beck, J Canon, A Chen, D Chow, J Duquette, ... Journal of Medicinal Chemistry 57 (7), 2963-2988, 2014 | 73 | 2014 |
| New reagents, reactions, and peptidomimetics for drug design M Goodman, C Zapf, Y Rew Peptide Science: Original Research on Biomolecules 60 (3), 229-245, 2001 | 71 | 2001 |
| Alanine Scan of [l-Dap2]Ramoplanin A2 Aglycon: Assessment of the Importance of Each Residue J Nam, D Shin, Y Rew, DL Boger Journal of the American Chemical Society 129 (28), 8747-8755, 2007 | 62 | 2007 |
| Discovery of novel, potent benzamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model LD Julian, Z Wang, T Bostick, S Caille, R Choi, M DeGraffenreid, Y Di, ... Journal of medicinal chemistry 51 (13), 3953-3960, 2008 | 56 | 2008 |
| Total synthesis and examination of three key analogues of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity Y Rew, D Shin, I Hwang, DL Boger Journal of the American Chemical Society 126 (4), 1041-1043, 2004 | 53 | 2004 |
| Solid-phase synthesis of amine-bridged cyclic enkephalin analogues via on-resin cyclization utilizing the Fukuyama− Mitsunobu reaction Y Rew, M Goodman The Journal of Organic Chemistry 67 (25), 8820-8826, 2002 | 53 | 2002 |
| Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors HP Beck, M DeGraffenreid, B Fox, JG Allen, Y Rew, S Schneider, AY Saiki, ... Bioorganic & medicinal chemistry letters 21 (9), 2752-2755, 2011 | 50 | 2011 |
| Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics L Chen, Y Yuan, JS Helm, Y Hu, Y Rew, D Shin, DL Boger, S Walker Journal of the American Chemical Society 126 (24), 7462-7463, 2004 | 50 | 2004 |
| Total synthesis and structure of the ramoplanin A1 and A3 aglycons: Two minor components of the ramoplanin complex D Shin, Y Rew, DL Boger Proceedings of the National Academy of Sciences 101 (33), 11977-11979, 2004 | 49 | 2004 |
| An efficient and scalable one-pot double Michael addition-Dieckmann condensation for the synthesis of 4, 4-disubstituted cyclohexane β-keto esters MR Degraffenreid, S Bennett, S Caille, F Gonzalez-Lopez de Turiso, ... The Journal of Organic Chemistry 72 (19), 7455-7458, 2007 | 43 | 2007 |
