Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome P Kahlem, M Sultan, R Herwig, M Steinfath, D Balzereit, B Eppens, ... Genome research 14 (7), 1258-1267, 2004 | 306 | 2004 |
Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: relevance to diseases of the nervous system P Kahlem, C Terre, H Green, P Djian Proceedings of the National Academy of Sciences 93 (25), 14580-14585, 1996 | 255 | 1996 |
Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with β-tubulin: relevance to Huntington's disease G Hoffner, P Kahlem, P Djian Journal of cell science 115 (5), 941-948, 2002 | 250 | 2002 |
Transglutaminase action imitates Huntington's disease: selective polymerization of Huntingtin containing expanded polyglutamine P Kahlem, H Green, P Djian Molecular cell 1 (4), 595-601, 1998 | 246 | 1998 |
Cellular senescence in cancer treatment: friend or foe? P Kahlem, B Dörken, CA Schmitt The Journal of clinical investigation 113 (2), 169-174, 2004 | 134 | 2004 |
A gene expression map of human chromosome 21 orthologues in the mouse HSA21 expression map initiative* Group 1: Gitton Yorick 2 Dahmane Nadia 3 ... Nature 420 (6915), 586-590, 2002 | 132 | 2002 |
A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells M Jung, H Peterson, L Chavez, P Kahlem, H Lehrach, J Vilo, J Adjaye PLoS One 5 (5), e10709, 2010 | 105 | 2010 |
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins YH Hu, HJ Warnatz, D Vanhecke, F Wagner, A Fiebitz, S Thamm, ... BMC genomics 7, 1-10, 2006 | 47 | 2006 |
Ten simple rules for making training materials FAIR L Garcia, B Batut, ML Burke, M Kuzak, F Psomopoulos, R Arcila, ... PLOS Computational Biology 16 (5), e1007854, 2020 | 42 | 2020 |
Gene-dosage effect on chromosome 21 transcriptome in trisomy 21: implication in Down syndrome cognitive disorders P Kahlem Behavior genetics 36 (3), 416-428, 2006 | 41 | 2006 |
The roadmap for implementing value-based healthcare in European university hospitals—consensus report and recommendations Y Cossio-Gil, M Omara, C Watson, J Casey, A Chakhunashvili, ... Value in Health 25 (7), 1148-1156, 2022 | 40 | 2022 |
Informatics approaches to understanding TGFβ pathway regulation P Kahlem, SJ Newfeld Development 136 (22), 3729-3740, 2009 | 36 | 2009 |
Dry work in a wet world: computation in systems biology P Kahlem, E Birney Molecular systems biology 2 (1), 40, 2006 | 36 | 2006 |
The expanded CAG repeat associated with juvenile Huntington disease shows a common origin of most or all neurons and glia in human cerebrum P Kahlem, P Djian Neuroscience letters 286 (3), 203-207, 2000 | 27 | 2000 |
ELIXIR‐EXCELERATE: establishing Europe's data infrastructure for the life science research of the future J Harrow, J Hancock, ELIXIR‐EXCELERATE Community, N Blomberg, ... The EMBO journal 40 (6), e107409, 2021 | 23 | 2021 |
Exclusion of HRAS from long QT locus N Roy, P Kahlem, E Dausse, M Bennaceur, S Fauré, J Weissenbach, ... Nature Genetics 8 (2), 113-114, 1994 | 23 | 1994 |
HSA21 expression map initiative Y Gitton, N Dahmane, S Baik, A Ruiz i Altaba, L Neidhardt, M Scholze, ... A gene expression map of human chromosome 21, 586-590, 2002 | 15 | 2002 |
Transglutaminase as the agent of neurodegenerative diseases due to polyglutamine expansion. P Kahlem, H Green, P Djian Pathologie-biologie 46 (9), 681-682, 1998 | 14 | 1998 |
The challenges of systems biology: community efforts to harness biological complexity G Stolovitzky, P Kahlem, A Califano (No Title), 2009 | 13* | 2009 |
ENFIN—a Network to Enhance Integrative Systems Biology P Kahlem, E Birney Annals of the New York Academy of Sciences 1115 (1), 23-31, 2007 | 12 | 2007 |