| Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors SM Chambers, Y Qi, Y Mica, G Lee, XJ Zhang, L Niu, J Bilsland, L Cao, ... Nature biotechnology 30 (7), 715-720, 2012 | 619 | 2012 |
| K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac YY Dong, ACW Pike, A Mackenzie, C McClenaghan, P Aryal, L Dong, ... Science 347 (6227), 1256-1259, 2015 | 317 | 2015 |
| Molecular and functional variation in iPSC-derived sensory neurons J Schwartzentruber, S Foskolou, H Kilpinen, J Rodrigues, K Alasoo, ... Nature genetics 50 (1), 54-61, 2018 | 205 | 2018 |
| Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia L Cao, A McDonnell, A Nitzsche, A Alexandrou, PP Saintot, AJC Loucif, ... Science translational medicine 8 (335), 335ra56-335ra56, 2016 | 190 | 2016 |
| An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum SJ Fountain, K Parkinson, MT Young, L Cao, CRL Thompson, RA North Nature 448 (7150), 200-203, 2007 | 173 | 2007 |
| Characterizing human stem cell–derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research GT Young, A Gutteridge, HDE Fox, AL Wilbrey, L Cao, LT Cho, AR Brown, ... Molecular Therapy 22 (8), 1530-1543, 2014 | 150 | 2014 |
| The biophysical and molecular basis of TRPV1 proton gating E Aneiros, L Cao, M Papakosta, EB Stevens, S Phillips, C Grimm The EMBO journal 30 (6), 994-1002, 2011 | 118 | 2011 |
| Permeation properties of a P2X receptor in the green algae Ostreococcus tauri SJ Fountain, L Cao, MT Young, RA North Journal of Biological Chemistry 283 (22), 15122-15126, 2008 | 98 | 2008 |
| Thr339-to-serine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308 L Cao, MT Young, HE Broomhead, SJ Fountain, RA North Journal of Neuroscience 27 (47), 12916-12923, 2007 | 68 | 2007 |
| Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels EL Veale, E Al-Moubarak, N Bajaria, K Omoto, L Cao, SJ Tucker, ... Molecular pharmacology 85 (5), 671-681, 2014 | 66 | 2014 |
| Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectification L Cao, HE Broomhead, MT Young, RA North Journal of Neuroscience 29 (45), 14257-14264, 2009 | 62 | 2009 |
| Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF … SA Nickolls, R Gurrell, G van Amerongen, J Kammonen, L Cao, AR Brown, ... British journal of pharmacology 175 (4), 708-725, 2018 | 53 | 2018 |
| GI‐530159, a novel, selective, mechanosensitive two‐pore‐domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability AJC Loucif, PP Saintot, J Liu, BM Antonio, SG Zellmer, K Yoger, EL Veale, ... British journal of pharmacology 175 (12), 2272-2283, 2018 | 49 | 2018 |
| P2X receptor channels show threefold symmetry in ionic charge selectivity and unitary conductance LE Browne, L Cao, HE Broomhead, L Bragg, WJ Wilkinson, RA North Nature neuroscience 14 (1), 17-18, 2011 | 43 | 2011 |
| The chimeric approach reveals that differences in the TRPV1 pore domain determine species-specific sensitivity to block of heat activation M Papakosta, C Dalle, A Haythornthwaite, L Cao, EB Stevens, G Burgess, ... Journal of Biological Chemistry 286 (45), 39663-39672, 2011 | 37 | 2011 |
| Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865) RM Owen, D Blakemore, L Cao, N Flanagan, R Fish, KR Gibson, ... Journal of Medicinal Chemistry 62 (12), 5773-5796, 2019 | 36 | 2019 |
| Interaction of the protein phosphatase 2A with the regulatory domain of the cystic fibrosis transmembrane conductance regulator channel A Vastiau, L Cao, M Jaspers, G Owsianik, V Janssens, H Cuppens, ... FEBS letters 579 (16), 3392-3396, 2005 | 27 | 2005 |
| Rescue of functional ΔF508-CFTR channels by co-expression with truncated CFTR constructs in COS-1 cells G Owsianik, L Cao, B Nilius FEBS letters 554 (1-2), 173-178, 2003 | 25 | 2003 |
| Chronic exposure to EGF affects trafficking and function of ENaC channel in cystic fibrosis cells L Cao, G Owsianik, F Becq, B Nilius Biochemical and biophysical research communications 331 (2), 503-511, 2005 | 18 | 2005 |
| Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K2P18. 1 A Monteillier, A Loucif, K Omoto, EB Stevens, S Lainez, PP Saintot, L Cao, ... Bioorganic & Medicinal Chemistry Letters 26 (20), 4919-4924, 2016 | 16 | 2016 |
