Mesencephalic astrocyte-derived neurotrophic factor (MANF) secretion and cell surface binding are modulated by KDEL receptors MJ Henderson, CT Richie, M Airavaara, Y Wang, BK Harvey Journal of Biological Chemistry 288 (6), 4209-4225, 2013 | 161 | 2013 |
KDM5 histone demethylases repress immune response via suppression of STING L Wu, J Cao, WL Cai, SM Lang, JR Horton, DJ Jansen, ZZ Liu, JF Chen, ... PLoS biology 16 (8), e2006134, 2018 | 127 | 2018 |
GCF2/LRRFIP1 represses tumor necrosis factor alpha expression AR Suriano, AN Sanford, N Kim, M Oh, S Kennedy, MJ Henderson, ... Molecular and cellular biology 25 (20), 9073-9081, 2005 | 103 | 2005 |
KDEL receptors are differentially regulated to maintain the ER proteome under calcium deficiency KA Trychta, S Bäck, MJ Henderson, BK Harvey Cell reports 25 (7), 1829-1840. e6, 2018 | 102 | 2018 |
Structural basis for KDM5A histone lysine demethylase inhibition by diverse compounds JR Horton, X Liu, M Gale, L Wu, JR Shanks, X Zhang, PJ Webber, ... Cell chemical biology 23 (7), 769-781, 2016 | 98 | 2016 |
A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase NJ Martinez, RR Asawa, MG Cyr, A Zakharov, DJ Urban, JS Roth, ... Scientific reports 8 (1), 9472, 2018 | 97 | 2018 |
Optogenetic inhibition of dorsal medial prefrontal cortex attenuates stress-induced reinstatement of palatable food seeking in female rats DJ Calu, AB Kawa, NJ Marchant, BM Navarre, MJ Henderson, B Chen, ... Journal of Neuroscience 33 (1), 214-226, 2013 | 93 | 2013 |
Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays DJ Urban, NJ Martinez, MI Davis, KR Brimacombe, DM Cheff, TD Lee, ... Scientific reports 7 (1), 12758, 2017 | 84 | 2017 |
A low affinity GCaMP3 variant (GCaMPer) for imaging the endoplasmic reticulum calcium store MJ Henderson, HA Baldwin, CA Werley, S Boccardo, LR Whitaker, X Yan, ... PloS one 10 (10), e0139273, 2015 | 84 | 2015 |
Ipomoeassin F binds Sec61α to inhibit protein translocation G Zong, Z Hu, S O’keefe, D Tranter, MJ Iannotti, L Baron, B Hall, ... Journal of the American Chemical Society 141 (21), 8450-8461, 2019 | 71 | 2019 |
Design, synthesis, and biological evaluation of quinazolin-4-one-based hydroxamic acids as dual PI3K/HDAC inhibitors A Thakur, GJ Tawa, MJ Henderson, C Danchik, S Liu, P Shah, AQ Wang, ... Journal of medicinal chemistry 63 (8), 4256-4292, 2020 | 70 | 2020 |
The SARS-CoV-2 cytopathic effect is blocked by lysosome alkalizing small molecules K Gorshkov, CZ Chen, R Bostwick, L Rasmussen, BN Tran, YS Cheng, ... ACS infectious diseases 7 (6), 1389-1408, 2020 | 67 | 2020 |
SERCaMP: a carboxy-terminal protein modification that enables monitoring of ER calcium homeostasis MJ Henderson, ES Wires, KA Trychta, CT Richie, BK Harvey Molecular biology of the cell 25 (18), 2828-2839, 2014 | 63 | 2014 |
High fat diet disrupts endoplasmic reticulum calcium homeostasis in the rat liver ES Wires, KA Trychta, S Bäck, A Sulima, KC Rice, BK Harvey Journal of hepatology 67 (5), 1009-1017, 2017 | 61 | 2017 |
High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2 NP Coussens, SC Kales, MJ Henderson, OW Lee, KY Horiuchi, Y Wang, ... Journal of Biological Chemistry 293 (35), 13750-13765, 2018 | 59 | 2018 |
High-throughput cellular thermal shift assays in research and drug discovery MJ Henderson, MA Holbert, A Simeonov, LA Kallal SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (2), 137-147, 2020 | 49 | 2020 |
Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome SJ Park, Y Kim, SM Yang, MJ Henderson, W Yang, M Lindahl, F Urano, ... Proceedings of the National Academy of Sciences 116 (28), 14154-14163, 2019 | 49 | 2019 |
Small molecule grp94 inhibitors block dengue and Zika virus replication HA Rothan, Y Zhong, MA Sanborn, TC Teoh, J Ruan, R Yusof, J Hang, ... Antiviral Research 171, 104590, 2019 | 48 | 2019 |
Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice KD MacDonald, KR McKenzie, MJ Henderson, CE Hawkins, N Vij, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 295 (5 …, 2008 | 45 | 2008 |
Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus Y Zhong, J Wang, MJ Henderson, P Yang, BM Hagen, T Siddique, ... Elife 6, e23759, 2017 | 39 | 2017 |