Squalenoyl nanomedicines as potential therapeutics P Couvreur, B Stella, LH Reddy, H Hillaireau, C Dubernet, D Desmaële, ... Nano letters 6 (11), 2544-2548, 2006 | 364 | 2006 |
Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury A Gaudin, M Yemisci, H Eroglu, S Lepetre-Mouelhi, OF Turkoglu, ... Nature nanotechnology 9 (12), 1054-1062, 2014 | 241 | 2014 |
Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue P Couvreur, LH Reddy, S Mangenot, JH Poupaert, D Desmaële, ... Small 4 (2), 247-253, 2008 | 153 | 2008 |
A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types LH Reddy, C Dubernet, SL Mouelhi, PE Marque, D Desmaele, ... Journal of controlled release 124 (1-2), 20-27, 2007 | 152 | 2007 |
Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery D Sobot, S Mura, SO Yesylevskyy, L Dalbin, F Cayre, G Bort, J Mougin, ... Nature communications 8 (1), 15678, 2017 | 114 | 2017 |
Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice LH Reddy, H Khoury, A Paci, A Deroussent, H Ferreira, C Dubernet, ... Drug Metabolism and Disposition 36 (8), 1570-1577, 2008 | 111 | 2008 |
Transmembrane diffusion of gemcitabine by a nanoparticulate squalenoyl prodrug: an original drug delivery pathway L Bildstein, C Dubernet, V Marsaud, H Chacun, V Nicolas, C Gueutin, ... Journal of controlled release 147 (2), 163-170, 2010 | 108 | 2010 |
Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine LH Reddy, PE Marque, C Dubernet, SL Mouelhi, D Desmaele, ... Journal of Pharmacology and Experimental Therapeutics 325 (2), 484-490, 2008 | 102 | 2008 |
Polyisoprenoyl gemcitabine conjugates self assemble as nanoparticles, useful for cancer therapy A Maksimenko, J Mougin, S Mura, E Sliwinski, E Lepeltier, C Bourgaux, ... Cancer letters 334 (2), 346-353, 2013 | 83 | 2013 |
Novel PEGylated Nanoassemblies Made of Self‐Assembled Squalenoyl Nucleoside Analogues F Bekkara‐Aounallah, R Gref, M Othman, LH Reddy, B Pili, V Allain, ... Advanced functional materials 18 (22), 3715-3725, 2008 | 83 | 2008 |
Anticancer efficacy of squalenoyl gemcitabine nanomedicine on 60 human tumor cell panel and on experimental tumor LH Reddy, JM Renoir, V Marsaud, S Lepetre-Mouelhi, D Desmaële, ... Molecular pharmaceutics 6 (5), 1526-1535, 2009 | 81 | 2009 |
A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine J Feng, S Lepetre-Mouelhi, A Gautier, S Mura, C Cailleau, F Coudore, ... Science advances 5 (2), eaau5148, 2019 | 73 | 2019 |
Interaction of a new anticancer prodrug, gemcitabine–squalene, with a model membrane: Coupled DSC and XRD study B Pili, C Bourgaux, H Amenitsch, G Keller, S Lepêtre-Mouelhi, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1798 (8), 1522-1532, 2010 | 53 | 2010 |
Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues J Caron, LH Reddy, S Lepêtre-Mouelhi, S Wack, P Clayette, ... Bioorganic & medicinal chemistry letters 20 (9), 2761-2764, 2010 | 53 | 2010 |
Self-assembly of squalene-based nucleolipids: relating the chemical structure of the bioconjugates to the architecture of the nanoparticles E Lepeltier, C Bourgaux, V Rosilio, JH Poupaert, F Meneau, F Zouhiri, ... Langmuir 29 (48), 14795-14803, 2013 | 50 | 2013 |
Interaction of self-assembled squalenoyl gemcitabine nanoparticles with phospholipid− cholesterol monolayers mimicking a biomembrane A Ambike, V Rosilio, B Stella, S Lepetre-Mouelhi, P Couvreur Langmuir 27 (8), 4891-4899, 2011 | 48 | 2011 |
Translation of nanomedicines from lab to industrial scale synthesis: The case of squalene-adenosine nanoparticles F Dormont, M Rouquette, C Mahatsekake, F Gobeaux, A Peramo, ... Journal of controlled release 307, 302-314, 2019 | 47 | 2019 |
Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation B Pili, LH Reddy, C Bourgaux, S Lepêtre-Mouelhi, D Desmaële, ... Nanoscale 2 (8), 1521-1526, 2010 | 46 | 2010 |
Squalenoyl nanomedicine of gemcitabine is more potent after oral administration in leukemia-bearing rats: study of mechanisms LH Reddy, H Ferreira, C Dubernet, SL Mouelhi, D Desmaele, B Rousseau, ... Anti-cancer drugs 19 (10), 999-1006, 2008 | 45 | 2008 |
Transport mechanisms of squalenoyl-adenosine nanoparticles across the blood–brain barrier A Gaudin, O Tagit, D Sobot, S Lepetre-Mouelhi, J Mougin, TF Martens, ... Chemistry of Materials 27 (10), 3636-3647, 2015 | 42 | 2015 |