A brain serine/threonine protein kinase activated by Cdc42 and Rac1 E Manser, T Leung, H Salihuddin, Z Zhao, L Lim Nature 367 (6458), 40-46, 1994 | 1923 | 1994 |
The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton T Leung, XQ Chen, E Manser, L Lim Molecular and cellular biology, 1996 | 1162 | 1996 |
A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes T Leung, E Manser, L Tan, L Lim Journal of Biological Chemistry 270 (49), 29051-29054, 1995 | 1022 | 1995 |
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors E Manser, TH Loo, CG Koh, ZS Zhao, XQ Chen, L Tan, I Tan, T Leung, ... Molecular cell 1 (2), 183-192, 1998 | 953 | 1998 |
Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes E Manser, HY Huang, TH Loo, XQ Chen, JM Dong, T Leung, L Lim Molecular and cellular biology, 1997 | 752 | 1997 |
Rho GTPases and their role in organizing the actin cytoskeleton ST Sit, E Manser Journal of cell science 124 (5), 679-683, 2011 | 620 | 2011 |
Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. F Cvrckova, C De Virgilio, E Manser, JR Pringle, K Nasmyth Genes & development 9 (15), 1817-1830, 1995 | 503 | 1995 |
Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly Z Zhao, E Manser, TH Loo, L Lim Molecular and cellular biology, 2000 | 489 | 2000 |
A conserved negative regulatory region in αPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1 ZS Zhao, E Manser, XQ Chen, C Chong, T Leung, L Lim Molecular and cellular biology, 1998 | 409 | 1998 |
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42 E Manser, T Leung, H Salihuddin, L Tan, L Lim Nature 363 (6427), 364-367, 1993 | 409 | 1993 |
Regulation of phosphorylation pathways by p21 GTPases: The p21 Ras‐related Rho subfamily and its role in phosphorylation signalling pathways L Lim, E Manser, T Leung, C Hall European Journal of Biochemistry 242 (2), 171-185, 1996 | 404 | 1996 |
PRL-3 and PRL-1 promote cell migration, invasion, and metastasis Q Zeng, JM Dong, K Guo, J Li, HX Tan, V Koh, CJ Pallen, E Manser, ... Cancer research 63 (11), 2716-2722, 2003 | 394 | 2003 |
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization T Leung, XQ Chen, I Tan, E Manser, L Lim Molecular and cellular biology, 1998 | 359 | 1998 |
PAK and other Rho-associated kinases–effectors with surprisingly diverse mechanisms of regulation Z Zhao, E Manser Biochemical Journal 386 (2), 201-214, 2005 | 357 | 2005 |
cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKα JM Dong, T Leung, E Manser, L Lim Journal of Biological Chemistry 273 (35), 22554-22562, 1998 | 335 | 1998 |
Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family (∗) E Manser, C Chong, ZS Zhao, T Leung, G Michael, C Hall, L Lim Journal of Biological Chemistry 270 (42), 25070-25078, 1995 | 327 | 1995 |
PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition H Wang, SY Quah, JM Dong, E Manser, JP Tang, Q Zeng Cancer research 67 (7), 2922-2926, 2007 | 322 | 2007 |
The mechanism of PAK activation: autophosphorylation events in both regulatory and kinase domains control activity C Chong, L Tan, L Lim, E Manser Journal of Biological Chemistry 276 (20), 17347-17353, 2001 | 313 | 2001 |
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A Z Zhao, JP Lim, YW Ng, L Lim, E Manser Molecular cell 20 (2), 237-249, 2005 | 292 | 2005 |
A Drosophila Homolog of the Rac- and Cdc42-Activated Serine/Threonine Kinase PAK Is a Potential Focal Adhesion and Focal Complex Protein That Colocalizes … N Harden, J Lee, HY Loh, YM Ong, I Tan, T Leung, E Manser, L Lim Molecular and cellular biology 16 (5), 1896-1908, 1996 | 271 | 1996 |