| The most infectious prion protein particles JR Silveira, GJ Raymond, AG Hughson, RE Race, VL Sim, SF Hayes, ... Nature 437 (7056), 257-261, 2005 | 1089 | 2005 |
| Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein R Atarashi, RA Moore, VL Sim, AG Hughson, DW Dorward, HA Onwubiko, ... Nature methods 4 (8), 645-650, 2007 | 397 | 2007 |
| The therapeutic potential of chemical chaperones in protein folding diseases L Cortez, V Sim Prion 8 (2), 197-202, 2014 | 256 | 2014 |
| Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils VL Sim, B Caughey Neurobiology of aging 30 (12), 2031-2042, 2009 | 114 | 2009 |
| Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor JGR Weaver, A Tarze, TC Moffat, M LeBras, A Deniaud, C Brenner, ... The Journal of clinical investigation 115 (7), 1828-1838, 2005 | 102 | 2005 |
| The mechanism of membrane disruption by cytotoxic amyloid oligomers formed by prion protein (106–126) is dependent on bilayer composition P Walsh, G Vanderlee, J Yau, J Campeau, VL Sim, CM Yip, S Sharpe Journal of Biological Chemistry 289 (15), 10419-10430, 2014 | 79 | 2014 |
| Recent advances in prion chemotherapeutics VL Sim, B Caughey Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2009 | 74 | 2009 |
| Bile acids reduce prion conversion, reduce neuronal loss, and prolong male survival in models of prion disease LM Cortez, J Campeau, G Norman, M Kalayil, J Van der Merwe, ... Journal of virology 89 (15), 7660-7672, 2015 | 70 | 2015 |
| Prion strain-dependent differences in conversion of mutant prion proteins in cell culture R Atarashi, VL Sim, N Nishida, B Caughey, S Katamine Journal of virology 80 (16), 7854-7862, 2006 | 59 | 2006 |
| Structure-based peptide design to modulate amyloid beta aggregation and reduce cytotoxicity J Kumar, R Namsechi, VL Sim PLoS One 10 (6), e0129087, 2015 | 57 | 2015 |
| D-amino acid-based peptide inhibitors as early or preventative therapy in Alzheimer disease J Kumar, V Sim Prion 8 (1), 119-124, 2014 | 49 | 2014 |
| Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein AN Gupta, K Neupane, N Rezajooei, LM Cortez, VL Sim, MT Woodside Nature Communications 7 (1), 12058, 2016 | 47 | 2016 |
| Early increase and late decrease of purkinje cell dendritic spine density in prion-infected organotypic mouse cerebellar cultures JL Campeau, G Wu, JR Bell, J Rasmussen, VL Sim PloS one 8 (12), e81776, 2013 | 43 | 2013 |
| Metronidazole susceptibility and the presence of hydrogenase in pathogenic bacteria DL Church, RD Bryant, V Sim, EJ Laishley Anaerobe 2 (3), 147-153, 1996 | 35 | 1996 |
| Characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase early amyloid-like oligomers and their implication in α-synuclein aggregation CM Torres-Bugeau, CL Ávila, R Raisman-Vozari, D Papy-Garcia, R Itri, ... Journal of Biological Chemistry 287 (4), 2398-2409, 2012 | 33 | 2012 |
| Molecular heterosis of prion protein β-oligomers: A potential mechanism of human resistance to disease A Tahiri-Alaoui, VL Sim, B Caughey, W James Journal of biological chemistry 281 (45), 34171-34178, 2006 | 32 | 2006 |
| Infectious prions accumulate to high levels in non proliferative C2C12 myotubes A Herbst, P Banser, CD Velasquez, CE Mays, VL Sim, D Westaway, ... PLoS Pathogens 9 (11), e1003755, 2013 | 30 | 2013 |
| Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice T Ali, S Hannaoui, S Nemani, W Tahir, I Zemlyankina, P Cherry, SY Shim, ... Acta Neuropathologica Communications 9, 1-14, 2021 | 26 | 2021 |
| The Effects of N-terminal Mutations on β-amyloid Peptide Aggregation and Toxicity BV Foroutanpay, J Kumar, SG Kang, N Danaei, D Westaway, VL Sim, ... Neuroscience 379, 177-188, 2018 | 25 | 2018 |
| TREM2 expression in the brain and biological fluids in prion diseases D Diaz-Lucena, N Kruse, K Thüne, M Schmitz, A Villar-Piqué, ... Acta neuropathologica 141, 841-859, 2021 | 24 | 2021 |
