| CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone Y Uno, H Fujino, G Kito, T Kamataki, R Nagata Molecular pharmacology 70 (2), 477-486, 2006 | 124 | 2006 |
| Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function Y Uno, K Iwasaki, H Yamazaki, DR Nelson Drug metabolism reviews 43 (3), 346-361, 2011 | 115 | 2011 |
| Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes Y Uno, S Uehara, H Yamazaki Biochemical pharmacology 121, 1-7, 2016 | 76 | 2016 |
| Ancient genome‐wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta N Osada, Y Uno, K Mineta, Y Kameoka, I Takahashi, K Terao Molecular Ecology 19 (14), 2884-2895, 2010 | 71 | 2010 |
| Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism? Y Uno, S Hosaka, K Matsuno, C Nakamura, G Kito, T Kamataki, R Nagata Archives of Biochemistry and Biophysics 466 (1), 98-105, 2007 | 71 | 2007 |
| Cynomolgus monkey CYPs: a comparison with human CYPs K Iwasaki, Y Uno Xenobiotica 39 (8), 578-581, 2009 | 70 | 2009 |
| Natural selection in the TLR-related genes in the course of primate evolution T Nakajima, H Ohtani, Y Satta, Y Uno, H Akari, T Ishida, A Kimura Immunogenetics 60, 727-735, 2008 | 66 | 2008 |
| Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques Y Uno, A Matsushita, N Osada, S Uehara, S Kohara, R Nagata, ... Drug metabolism and disposition 38 (2), 209-214, 2010 | 61 | 2010 |
| Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys S Uehara, N Murayama, Y Nakanishi, DC Zeldin, H Yamazaki, Y Uno Journal of Pharmacology and Experimental Therapeutics 339 (2), 654-661, 2011 | 60 | 2011 |
| Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter Y Uno, Y Sakamoto, K Yoshida, T Hasegawa, Y Hasegawa, T Koshino, ... Journal of human genetics 48 (11), 594-597, 2003 | 53 | 2003 |
| Large-scale analysis of Macaca fascicularis transcripts and inference of genetic divergence between M. fascicularis and M. mulatta N Osada, K Hashimoto, Y Kameoka, M Hirata, R Tanuma, Y Uno, I Inoue, ... BMC genomics 9, 1-15, 2008 | 48 | 2008 |
| Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs M Yamazaki, M Shimizu, Y Uno, H Yamazaki Biochemical pharmacology 90 (2), 159-165, 2014 | 47 | 2014 |
| Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate G Chowdhury, N Murayama, Y Okada, Y Uno, M Shimizu, N Shibata, ... Chemical research in toxicology 23 (6), 1018-1024, 2010 | 46 | 2010 |
| CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey Y Uno, S Uehara, N Murayama, H Yamazaki Biochemical pharmacology 81 (3), 442-450, 2011 | 45 | 2011 |
| CYP2C76-mediated species difference in drug metabolism: A comparison of pitavastatin metabolism between monkeys and humans Y Uno, T Kumano, G Kito, R Nagata, T Kamataki, H Fujino Xenobiotica 37 (1), 30-43, 2007 | 45 | 2007 |
| Novel marmoset cytochrome P450 2C19 in livers efficiently metabolizes human P450 2C9 and 2C19 substrates, S-warfarin, tolbutamide, flurbiprofen, and omeprazole S Uehara, Y Uno, T Inoue, M Kawano, M Shimizu, A Toda, M Utoh, ... Drug metabolism and disposition 43 (10), 1408-1416, 2015 | 44 | 2015 |
| Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan Y Uno, S Uehara, S Kohara, N Murayama, H Yamazaki Drug Metabolism and Disposition 38 (9), 1486-1492, 2010 | 41 | 2010 |
| A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: a possible genetic tool for generation of a better animal model in drug metabolism Y Uno, H Sakuraba, S Uehara, T Kumano, K Matsuno, C Nakamura, ... Drug metabolism and disposition 37 (1), 14-17, 2009 | 40 | 2009 |
| Pitavastatin as an in vivo probe for studying hepatic organic anion transporting polypeptide-mediated drug–drug interactions in cynomolgus monkeys T Takahashi, T Ohtsuka, T Yoshikawa, I Tatekawa, Y Uno, M Utoh, ... Drug Metabolism and Disposition 41 (10), 1875-1882, 2013 | 39 | 2013 |
| Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in … M Utoh, H Suemizu, M Mitsui, M Kawano, A Toda, S Uehara, Y Uno, ... Xenobiotica 46 (12), 1049-1055, 2016 | 37 | 2016 |
