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Alyssa Coyne
Alyssa Coyne
Johns Hopkins University School of Medicine
在 jhmi.edu 的电子邮件经过验证
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引用次数
引用次数
年份
Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease
B Eftekharzadeh, JG Daigle, LE Kapinos, A Coyne, J Schiantarelli, ...
Neuron 99 (5), 925-940. e7, 2018
3862018
Stress granule assembly disrupts nucleocytoplasmic transport
K Zhang, JG Daigle, KM Cunningham, AN Coyne, K Ruan, JC Grima, ...
Cell 173 (4), 958-971. e17, 2018
3612018
Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis
AN Coyne, BB Siddegowda, PS Estes, J Johannesmeyer, T Kovalik, ...
Journal of Neuroscience 34 (48), 15962-15974, 2014
1712014
CRISPR-Cas9 screens identify the RNA helicase DDX3X as a repressor of C9ORF72 (GGGGCC) n repeat-associated non-AUG translation
W Cheng, S Wang, Z Zhang, DW Morgens, LR Hayes, S Lee, B Portz, ...
Neuron 104 (5), 885-898. e8, 2019
1222019
G4C2 repeat RNA initiates a POM121-mediated reduction in specific nucleoporins in C9orf72 ALS/FTD
AN Coyne, BL Zaepfel, L Hayes, B Fitchman, Y Salzberg, EC Luo, ...
Neuron 107 (6), 1124-1140. e11, 2020
1082020
Endocytosis regulates TDP-43 toxicity and turnover
G Liu, AN Coyne, F Pei, S Vaughan, M Chaung, DC Zarnescu, JR Buchan
Nature communications 8 (1), 2092, 2017
1072017
Post-transcriptional inhibition of Hsc70-4/HSPA8 expression leads to synaptic vesicle cycling defects in multiple models of ALS
AN Coyne, I Lorenzini, CC Chou, M Torvund, RS Rogers, A Starr, ...
Cell reports 21 (1), 110-125, 2017
992017
Antibody therapy targeting RAN proteins rescues C9 ALS/FTD phenotypes in C9orf72 mouse model
L Nguyen, F Montrasio, A Pattamatta, SK Tusi, O Bardhi, KD Meyer, ...
Neuron 105 (4), 645-662. e11, 2020
912020
Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation
AN Coyne, SB Yamada, BB Siddegowda, PS Estes, BL Zaepfel, ...
Human molecular genetics 24 (24), 6886-6898, 2015
882015
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines
EG Baxi, T Thompson, J Li, JA Kaye, RG Lim, J Wu, D Ramamoorthy, ...
Nature neuroscience 25 (2), 226-237, 2022
852022
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS
AN Coyne, V Baskerville, BL Zaepfel, DW Dickson, F Rigo, F Bennett, ...
Science translational medicine 13 (604), eabe1923, 2021
792021
Failure to deliver and translate—new insights into RNA dysregulation in ALS
AN Coyne, BL Zaepfel, DC Zarnescu
Frontiers in cellular neuroscience 11, 243, 2017
562017
Nuclear pore complexes—a doorway to neural injury in neurodegeneration
AN Coyne, JD Rothstein
Nature Reviews Neurology 18 (6), 348-362, 2022
522022
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models
JA Bush, H Aikawa, R Fuerst, Y Li, A Ursu, SM Meyer, RI Benhamou, ...
Science translational medicine 13 (617), eabd5991, 2021
482021
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
H Phatnani, J Kwan, D Sareen, JR Broach, Z Simmons, X Arcila-Londono, ...
Iscience 24 (11), 2021
272021
Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease
B Eftekharzadeh, JG Daigle, LE Kapinos, A Coyne, J Schiantarelli, ...
Neuron 101 (2), 349, 2019
242019
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction
BL Zaepfel, Z Zhang, K Maulding, AN Coyne, W Cheng, LR Hayes, ...
Cell reports 34 (13), 2021
222021
Drosophila models of amyotrophic lateral sclerosis with defects in RNA metabolism
K Zhang, AN Coyne, TE Lloyd
Brain research 1693, 109-120, 2018
202018
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins
J Gao, QT Mewborne, A Girdhar, U Sheth, AN Coyne, R Punathil, ...
Science translational medicine 14 (662), eabq3215, 2022
122022
The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei
AN Coyne, JD Rothstein
Acta neuropathologica communications 9 (1), 127, 2021
122021
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