Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy J Zhang, EC Kim, C Chen, E Procko, S Pant, K Lam, J Patel, R Choi, ... Scientific reports 10 (1), 1-19, 2020 | 54 | 2020 |
The role of Kv7 channels in neural plasticity and behavior BC Baculis, J Zhang, HJ Chung Frontiers in Physiology, 1206, 2020 | 38 | 2020 |
Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy EC Kim, J Zhang, W Pang, S Wang, KY Lee, JP Cavaretta, J Walters, ... Neurobiology of disease 118, 76-93, 2018 | 35 | 2018 |
Heterozygous loss of epilepsy gene KCNQ2 alters social, repetitive and exploratory behaviors EC Kim, J Patel, J Zhang, H Soh, JS Rhodes, AV Tzingounis, HJ Chung Genes, Brain and Behavior 19 (1), e12599, 2020 | 34 | 2020 |
Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of Kv7. 2 EC Kim, J Zhang, AY Tang, EC Bolton, JS Rhodes, CA Christian-Hinman, ... Proceedings of the National Academy of Sciences 118 (51), 2021 | 16 | 2021 |
PIP2-dependent coupling of voltage sensor and pore domains in Kv7. 2 channel S Pant, J Zhang, EC Kim, K Lam, HJ Chung, E Tajkhorshid Communications biology 4 (1), 1-14, 2021 | 12 | 2021 |
An epilepsy-causing mutation leads to co-translational misfolding of the Kv7. 2 channel J Urrutia, A Aguado, C Gomis-Perez, A Muguruza-Montero, ... BMC biology 19 (1), 1-18, 2021 | 9 | 2021 |
Pharmacological inhibition of STriatal‐Enriched protein tyrosine Phosphatase by TC‐2153 reduces hippocampal excitability and seizure propensity JM Walters, EC Kim, J Zhang, HG Jeong, A Bajaj, BC Baculis, GC Tracy, ... Epilepsia, 2022 | 7 | 2022 |