| Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family KS Hewitson, LA McNeill, MV Riordan, YM Tian, AN Bullock, RW Welford, ... Journal of Biological Chemistry 277 (29), 26351-26355, 2002 | 914 | 2002 |
| Structural basis for protein–protein interactions in the 14-3-3 protein family X Yang, WH Lee, F Sobott, E Papagrigoriou, CV Robinson, ... Proceedings of the National Academy of Sciences 103 (46), 17237-17242, 2006 | 480 | 2006 |
| Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1α JM Elkins, KS Hewitson, LA McNeill, JF Seibel, I Schlemminger, CW Pugh, ... Journal of Biological Chemistry 278 (3), 1802-1806, 2003 | 473 | 2003 |
| Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy KVM Huber, E Salah, B Radic, M Gridling, JM Elkins, A Stukalov, ... Nature 508 (7495), 222-227, 2014 | 456 | 2014 |
| Comprehensive characterization of the published kinase inhibitor set JM Elkins, V Fedele, M Szklarz, KRA Azeez, E Salah, J Mikolajczyk, ... Nature biotechnology 34 (1), 95-103, 2016 | 352 | 2016 |
| Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors T Zhang, N Kwiatkowski, CM Olson, SE Dixon-Clarke, BJ Abraham, ... Nature chemical biology 12 (10), 876-884, 2016 | 342 | 2016 |
| X-ray Crystal Structure of Escherichia coli Taurine/α-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates, JM Elkins, MJ Ryle, IJ Clifton, JC Dunning Hotopp, JS Lloyd, NI Burzlaff, ... Biochemistry 41 (16), 5185-5192, 2002 | 301 | 2002 |
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B T Tahtouh, JM Elkins, P Filippakopoulos, M Soundararajan, G Burgy, ... Journal of medicinal chemistry 55 (21), 9312-9330, 2012 | 240 | 2012 |
| Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition M Soundararajan, AK Roos, P Savitsky, P Filippakopoulos, ... Structure 21 (6), 986-996, 2013 | 174 | 2013 |
| Salt-inducible kinase 2 couples ovarian cancer cell metabolism with survival at the adipocyte-rich metastatic niche F Miranda, D Mannion, S Liu, Y Zheng, LS Mangala, C Redondo, ... Cancer Cell 30 (2), 273-289, 2016 | 170 | 2016 |
| Progress towards a public chemogenomic set for protein kinases and a call for contributions DH Drewry, CI Wells, DM Andrews, R Angell, H Al-Ali, AD Axtman, ... PloS one 12 (8), e0181585, 2017 | 161 | 2017 |
| Family-wide Structural Analysis of Human Numb-Associated Protein Kinases FJ Sorrell, M Szklarz, KRA Azeez, JM Elkins, S Knapp Structure 24 (3), 401-411, 2016 | 154 | 2016 |
| Crystal structure of human aurora B in complex with INCENP and VX-680 JM Elkins, S Santaguida, A Musacchio, S Knapp Journal of medicinal chemistry 55 (17), 7841-7848, 2012 | 109 | 2012 |
| Donated chemical probes for open science S Müller, S Ackloo, CH Arrowsmith, M Bauser, JL Baryza, J Blagg, ... eLife 7, e34311, 2018 | 104 | 2018 |
| Type II inhibitors targeting CDK2 LT Alexander, H Möbitz, P Drueckes, P Savitsky, O Fedorov, JM Elkins, ... ACS chemical biology 10 (9), 2116-2125, 2015 | 102 | 2015 |
| Crystal structure of sphingosine kinase 1 with PF-543 J Wang, S Knapp, NJ Pyne, S Pyne, JM Elkins ACS medicinal chemistry letters 5 (12), 1329-1333, 2014 | 100 | 2014 |
| WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop MJ Agajanian, MP Walker, AD Axtman, RR Ruela-de-Sousa, DS Serafin, ... Cell reports 26 (1), 79-93. e8, 2019 | 84 | 2019 |
| Structure of PICK1 and other PDZ domains obtained with the help of self‐binding C‐terminal extensions JM Elkins, E Papagrigoriou, G Berridge, X Yang, C Phillips, C Gileadi, ... Protein science 16 (4), 683-694, 2007 | 84 | 2007 |
| Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target MM Alam, A Sanchez-Azqueta, O Janha, EL Flannery, A Mahindra, ... Science 365 (6456), 2019 | 79 | 2019 |
| Oxalyl boronates enable modular synthesis of bioactive imidazoles CF Lee, A Holownia, JM Bennett, JM Elkins, JD St. Denis, S Adachi, ... Angewandte Chemie International Edition 56 (22), 6264-6267, 2017 | 78 | 2017 |
Stefan KnappUniversity of Frankfurt在 pharmchem.uni-frankfurt.de 的电子邮件经过验证
