Complex interplay between autophagy and oxidative stress in the development of pulmonary disease W Ornatowski, Q Lu, M Yegambaram, AE Garcia, EA Zemskov, E Maltepe, ... Redox biology 36, 101679, 2020 | 288 | 2020 |
Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics Q Lu, EA Zemskov, X Sun, H Wang, M Yegambaram, X Wu, ... Redox Biology 38, 101785, 2021 | 35 | 2021 |
Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics MD Pokharel, A Garcia-Flores, D Marciano, MC Franco, JR Fineman, ... Redox Biology, 103049, 2024 | 19 | 2024 |
Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury AE Garcia-Flores, CM Gross, EA Zemskov, Q Lu, K Tieu, T Wang, ... Frontiers in Physiology 13, 1066515, 2022 | 7 | 2022 |
Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission Q Lu, X Sun, M Yegambaram, W Ornatowski, X Wu, H Wang, ... Journal of Biological Chemistry 299 (4), 2023 | 5 | 2023 |
HER2/HER3 regulates lactate secretion and expression of lactate receptor mRNA through the MAP3K4 associated protein GIT1 AE Garcia-Flores, JJ Sollome, E Thavathiru, JL Bower, RR Vaillancourt Scientific Reports 9 (1), 10823, 2019 | 5 | 2019 |
Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells M Yegambaram, X Sun, AG Flores, Q Lu, J Soto, J Richards, S Aggarwal, ... International Journal of Molecular Sciences 24 (24), 17533, 2023 | 4 | 2023 |
Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1 M Yegambaram, S Kumar, X Wu, Q Lu, X Sun, AG Flores, ML Meadows, ... Nitric Oxide 140, 50-57, 2023 | 3 | 2023 |
Inflammatory lung injury is associated with endothelial cell mitochondrial fission and requires the nitration of RhoA and cytoskeletal remodeling MD Pokharel, P Fu, A Garcia-Flores, M Yegambaram, Q Lu, X Sun, ... Free Radical Biology and Medicine 221, 125-135, 2024 | 2 | 2024 |
Ventilator-induced lung injury is associated with endothelial cell mitochondrial fission M Pokharel, P Fu, A Garcia-Flores, J Soto | | 2024 |
Targeting the mitochondrial fission-mediator Drp1 is a potential therapeutic strategy for ventilator induced lung injury M Pokharel, AG Flores, P Fu, Q Lu, X Sun, T Wang, S Black Free Radical Biology and Medicine 208, S94, 2023 | | 2023 |
Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases Y Liang, W Ornatowski, Q Lu, X Sun, AE Garcia, EA Zemskov, E Maltepe, ... Circulation 146 (Suppl_1), A13625-A13625, 2022 | | 2022 |
NAMPT induces Mitochondrial and Barrier Dysfunction in Pulmonary Endothelial Cells M Pokharel, AG Flores, Q Lu, X Sun, T Wang, K Tieu, S Black Free Radical Biology and Medicine 192, 69, 2022 | | 2022 |
The anti-apoptotic protein, Survivin induces a shift in endothelial cell in carbon metabolism through a mitochondrial-ROS-dependent increase in HIF-1a signaling Q Lu, X Sun, J Soto, H Gu, M Yegambaram, AG Flores, E Zemskov, ... Free Radical Biology and Medicine 192, 65-66, 2022 | | 2022 |
Mitochondrial Fission Drives A Glycolytic Endothelial Phenotype In Pulmonary Hypertension: Role Of Nitrated RhoA Q Lu, X Sun, M Yegambaram, W Ornatowski, X Wu, Q Zhang, H Wang, ... Free Radical Biology and Medicine 180, s49, 2022 | | 2022 |
Increased Mitochondrial Fission Induces a Warburg Phenotype Via the Hydrogen Peroxide Mediated inhibition of Prolyl Hydroxylase 2 (PHD2) in Pulmonary Arterial Endothelial Cells X Sun, M Yegambaram, Q Lu, AG Flores, X Wu, T Wang, J Fineman, ... Free Radical Biology and Medicine 180, s100, 2022 | | 2022 |
VILI Induced Nitration of RhoA Disrupts Mitochondrial Function Through Increased Generation of Reactive Oxygen Species AG Flores, Q Lu, X Sun, S Black Free Radical Biology and Medicine 180, s46, 2022 | | 2022 |
Autophagy plays a key role in hyper-proliferative phenotype in pulmonary vascular diseases W Ornatowski, Q Lu, X Sun, AG Flores, A Feng, E Zemskov, E Maltepe, ... Free Radical Biology and Medicine 180, s52, 2022 | | 2022 |
Role Of Mitochondrial ROS and HIF Signaling in the Metabolic Reprogramming Associated with Increased Sox18 Expression M Yegambaram, X Sun, Q Lu, AG Flores, W Ornatowski, V Da Silva, ... Free Radical Biology and Medicine 180, s56, 2022 | | 2022 |
The Role of MTK1 in Cell Migration and Extracellular Acidification AE Garcia Flores The University of Arizona., 2017 | | 2017 |