| Impact of high-throughput screening in biomedical research R Macarron, MN Banks, D Bojanic, DJ Burns, DA Cirovic, T Garyantes, ... Nature reviews Drug discovery 10 (3), 188-195, 2011 | 1560 | 2011 |
| Thousands of chemical starting points for antimalarial lead identification FJ Gamo, LM Sanz, J Vidal, C De Cozar, E Alvarez, JL Lavandera, ... Nature 465 (7296), 305-310, 2010 | 1167 | 2010 |
| Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure− activity … PW Smith, SL Sollis, PD Howes, PC Cherry, ID Starkey, KN Cobley, ... Journal of Medicinal Chemistry 41 (6), 787-797, 1998 | 447 | 1998 |
| Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity RJ Young, DVS Green, CN Luscombe, AP Hill Drug discovery today 16 (17-18), 822-830, 2011 | 336 | 2011 |
| Diversity screening versus focussed screening in drug discovery MJ Valler, D Green Drug discovery today 5 (7), 286-293, 2000 | 202 | 2000 |
| Combinatorial library design using a multiobjective genetic algorithm VJ Gillet, W Khatib, P Willett, PJ Fleming, DVS Green Journal of chemical information and computer sciences 42 (2), 375-385, 2002 | 197 | 2002 |
| Selecting combinatorial libraries to optimize diversity and physical properties VJ Gillet, P Willett, J Bradshaw, DVS Green Journal of Chemical Information and Computer Sciences 39 (1), 169-177, 1999 | 175 | 1999 |
| Prediction of biological activity for high-throughput screening using binary kernel discrimination G Harper, J Bradshaw, JC Gittins, DVS Green, AR Leach Journal of Chemical Information and Computer Sciences 41 (5), 1295-1300, 2001 | 160 | 2001 |
| Multiobjective optimization in quantitative structure− activity relationships: Deriving accurate and interpretable QSARs O Nicolotti, VJ Gillet, PJ Fleming, DVS Green Journal of Medicinal Chemistry 45 (23), 5069-5080, 2002 | 112 | 2002 |
| Application of high-throughput screening techniques to drug discovery B Cox, JC Denyer, A Binnie, MC Donnelly, B Evans, DVS Green, JA Lewis, ... Progress in Medicinal Chemistry 37, 83-134, 2000 | 112 | 2000 |
| Implementation of a system for reagent selection and library enumeration, profiling, and design AR Leach, J Bradshaw, DVS Green, MM Hann, JJ Delany Journal of chemical information and computer sciences 39 (6), 1161-1172, 1999 | 109 | 1999 |
| The reduced graph descriptor in virtual screening and data-driven clustering of high-throughput screening data G Harper, GS Bravi, SD Pickett, J Hussain, DVS Green Journal of chemical information and computer sciences 44 (6), 2145-2156, 2004 | 107 | 2004 |
| Quality guidelines for oral drug candidates: dose, solubility and lipophilicity MK Bayliss, J Butler, PL Feldman, DVS Green, PD Leeson, MR Palovich, ... Drug Discovery Today 21 (10), 1719-1727, 2016 | 101 | 2016 |
| Synthesis and anti-HIV-1 activity of a series of imidazo [1, 5-b] pyridazines DGH Livermore, RC Bethell, N Cammack, AP Hancock, MM Hann, ... Journal of medicinal chemistry 36 (24), 3784-3794, 1993 | 101 | 1993 |
| Design of a compound screening collection for use in high throughput screening G Harper, SD Pickett, DVS Green Combinatorial chemistry & high throughput screening 7 (1), 63-70, 2004 | 93 | 2004 |
| Benzophenone derivatives: a novel series of potent and selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase PG Wyatt, RC Bethell, N Cammack, D Charon, N Dodic, B Dumaitre, ... Journal of medicinal chemistry 38 (10), 1657-1665, 1995 | 92 | 1995 |
| Designing focused libraries using MoSELECT VJ Gillet, P Willett, PJ Fleming, DVS Green Journal of Molecular Graphics and Modelling 20 (6), 491-498, 2002 | 88 | 2002 |
| Rapid and reliable binding affinity prediction of bromodomain inhibitors: a computational study S Wan, AP Bhati, SJ Zasada, I Wall, D Green, P Bamborough, ... Journal of chemical theory and computation 13 (2), 784-795, 2017 | 85 | 2017 |
| Virtual screening of virtual libraries DVS Green Progress in medicinal chemistry 41, 61-97, 2003 | 76 | 2003 |
| The prediction of tautomer equilibria in hydrated 3-hydroxypyrazole: a challenge to theory OG Parchment, DVS Green, PJ Taylor, IH Hillier Journal of The American Chemical Society 115 (6), 2352-2356, 1993 | 68 | 1993 |
Andrew LeachHead of Chemical Biology, European Bioinformatics Institute在 ebi.ac.uk 的电子邮件经过验证
