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Jani Huuhtanen
Jani Huuhtanen
在 helsinki.fi 的电子邮件经过验证
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Single-cell RNA sequencing reveals a dynamic stromal niche that supports tumor growth
S Davidson, M Efremova, A Riedel, B Mahata, J Pramanik, J Huuhtanen, ...
Cell reports 31 (7), 2020
2212020
Immunogenomic landscape of hematological malignancies
O Dufva, P Pölönen, O Brück, MAI Keränen, J Klievink, J Mehtonen, ...
Cancer Cell 38 (3), 380-399. e13, 2020
1492020
Predicting recognition between T cell receptors and epitopes with TCRGP
E Jokinen, J Huuhtanen, S Mustjoki, M Heinonen, H Lähdesmäki
PLoS computational biology 17 (3), e1008814, 2021
942021
Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia
S Kollmann, E Grundschober, B Maurer, W Warsch, R Grausenburger, ...
Leukemia 33 (7), 1583-1597, 2019
552019
Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia
S Lundgren, MAI Keränen, M Kankainen, J Huuhtanen, G Walldin, ...
Leukemia 35 (5), 1365-1379, 2021
542021
Determining epitope specificity of T cell receptors with TCRGP
E Jokinen, J Huuhtanen, S Mustjoki, M Heinonen, H Lähdesmäki
BioRxiv, 542332, 2019
452019
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
H Kuusanmäki, O Dufva, M Vähä-Koskela, AM Leppä, J Huuhtanen, ...
Blood 141 (13), 1610-1625, 2023
412023
Single-cell characterization of anti–LAG-3 and anti–PD-1 combination treatment in patients with melanoma
J Huuhtanen, H Kasanen, K Peltola, T Lönnberg, V Glumoff, O Brück, ...
The Journal of Clinical Investigation 133 (6), 2023
312023
Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia
J Huuhtanen, D Bhattacharya, T Lönnberg, M Kankainen, C Kerr, ...
Nature Communications 13 (1), 1981, 2022
312022
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease
D Kim, G Park, J Huuhtanen, S Lundgren, RK Khajuria, AM Hurtado, ...
Nature communications 11 (1), 2246, 2020
282020
STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation
D Kim, G Park, J Huuhtanen, B Ghimire, H Rajala, R Moriggl, WC Chan, ...
Leukemia 35 (12), 3430-3443, 2021
272021
Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia
D Bhattacharya, A Teramo, VR Gasparini, J Huuhtanen, D Kim, ...
Blood cancer journal 12 (2), 31, 2022
242022
Somatic mutations and T-cell clonality in patients with immunodeficiency
P Savola, T Martelius, M Kankainen, J Huuhtanen, S Lundgren, Y Koski, ...
haematologica 105 (12), 2757, 2020
242020
Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia
H Kuusanmäki, S Kytölä, I Vänttinen, T Ruokoranta, A Ranta, ...
Haematologica 108 (7), 1768, 2023
232023
Evolution and modulation of antigen-specific T cell responses in melanoma patients
J Huuhtanen, L Chen, E Jokinen, H Kasanen, T Lönnberg, A Kreutzman, ...
Nature communications 13 (1), 5988, 2022
202022
TCRconv: predicting recognition between T cell receptors and epitopes using contextualized motifs
E Jokinen, A Dumitrescu, J Huuhtanen, V Gligorijević, S Mustjoki, ...
Bioinformatics 39 (1), btac788, 2023
162023
Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment
S Davidson, M Efremova, A Riedel, B Mahata, J Pramanik, J Huuhtanen, ...
bioRxiv, 467225, 2018
162018
Adult-onset anti-citrullinated peptide antibody-negative destructive rheumatoid arthritis is characterized by a disease-specific CD8+ T lymphocyte signature
T Kelkka, P Savola, D Bhattacharya, J Huuhtanen, T Lönnberg, ...
Frontiers in immunology 11, 578848, 2020
142020
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
O Dufva, S Gandolfi, J Huuhtanen, O Dashevsky, H Duàn, K Saeed, ...
Immunity 56 (12), 2816-2835. e13, 2023
122023
The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty's syndrome
P Savola, D Bhattacharya, J Huuhtanen
Seminars in Hematology 59 (3), 123-130, 2022
102022
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