Single-cell RNA sequencing reveals a dynamic stromal niche that supports tumor growth S Davidson, M Efremova, A Riedel, B Mahata, J Pramanik, J Huuhtanen, ... Cell reports 31 (7), 2020 | 221 | 2020 |
Immunogenomic landscape of hematological malignancies O Dufva, P Pölönen, O Brück, MAI Keränen, J Klievink, J Mehtonen, ... Cancer Cell 38 (3), 380-399. e13, 2020 | 149 | 2020 |
Predicting recognition between T cell receptors and epitopes with TCRGP E Jokinen, J Huuhtanen, S Mustjoki, M Heinonen, H Lähdesmäki PLoS computational biology 17 (3), e1008814, 2021 | 94 | 2021 |
Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia S Kollmann, E Grundschober, B Maurer, W Warsch, R Grausenburger, ... Leukemia 33 (7), 1583-1597, 2019 | 55 | 2019 |
Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia S Lundgren, MAI Keränen, M Kankainen, J Huuhtanen, G Walldin, ... Leukemia 35 (5), 1365-1379, 2021 | 54 | 2021 |
Determining epitope specificity of T cell receptors with TCRGP E Jokinen, J Huuhtanen, S Mustjoki, M Heinonen, H Lähdesmäki BioRxiv, 542332, 2019 | 45 | 2019 |
Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia H Kuusanmäki, O Dufva, M Vähä-Koskela, AM Leppä, J Huuhtanen, ... Blood 141 (13), 1610-1625, 2023 | 41 | 2023 |
Single-cell characterization of anti–LAG-3 and anti–PD-1 combination treatment in patients with melanoma J Huuhtanen, H Kasanen, K Peltola, T Lönnberg, V Glumoff, O Brück, ... The Journal of Clinical Investigation 133 (6), 2023 | 31 | 2023 |
Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia J Huuhtanen, D Bhattacharya, T Lönnberg, M Kankainen, C Kerr, ... Nature Communications 13 (1), 1981, 2022 | 31 | 2022 |
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease D Kim, G Park, J Huuhtanen, S Lundgren, RK Khajuria, AM Hurtado, ... Nature communications 11 (1), 2246, 2020 | 28 | 2020 |
STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation D Kim, G Park, J Huuhtanen, B Ghimire, H Rajala, R Moriggl, WC Chan, ... Leukemia 35 (12), 3430-3443, 2021 | 27 | 2021 |
Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia D Bhattacharya, A Teramo, VR Gasparini, J Huuhtanen, D Kim, ... Blood cancer journal 12 (2), 31, 2022 | 24 | 2022 |
Somatic mutations and T-cell clonality in patients with immunodeficiency P Savola, T Martelius, M Kankainen, J Huuhtanen, S Lundgren, Y Koski, ... haematologica 105 (12), 2757, 2020 | 24 | 2020 |
Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia H Kuusanmäki, S Kytölä, I Vänttinen, T Ruokoranta, A Ranta, ... Haematologica 108 (7), 1768, 2023 | 23 | 2023 |
Evolution and modulation of antigen-specific T cell responses in melanoma patients J Huuhtanen, L Chen, E Jokinen, H Kasanen, T Lönnberg, A Kreutzman, ... Nature communications 13 (1), 5988, 2022 | 20 | 2022 |
TCRconv: predicting recognition between T cell receptors and epitopes using contextualized motifs E Jokinen, A Dumitrescu, J Huuhtanen, V Gligorijević, S Mustjoki, ... Bioinformatics 39 (1), btac788, 2023 | 16 | 2023 |
Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment S Davidson, M Efremova, A Riedel, B Mahata, J Pramanik, J Huuhtanen, ... bioRxiv, 467225, 2018 | 16 | 2018 |
Adult-onset anti-citrullinated peptide antibody-negative destructive rheumatoid arthritis is characterized by a disease-specific CD8+ T lymphocyte signature T Kelkka, P Savola, D Bhattacharya, J Huuhtanen, T Lönnberg, ... Frontiers in immunology 11, 578848, 2020 | 14 | 2020 |
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers O Dufva, S Gandolfi, J Huuhtanen, O Dashevsky, H Duàn, K Saeed, ... Immunity 56 (12), 2816-2835. e13, 2023 | 12 | 2023 |
The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty's syndrome P Savola, D Bhattacharya, J Huuhtanen Seminars in Hematology 59 (3), 123-130, 2022 | 10 | 2022 |