| Predicting resistance mutations using protein design algorithms KM Frey, I Georgiev, BR Donald, AC Anderson Proceedings of the National Academy of Sciences 107 (31), 13707-13712, 2010 | 128 | 2010 |
| Picomolar inhibitors of HIV reverse transcriptase featuring bicyclic replacement of a cyanovinylphenyl group WG Lee, R Gallardo-Macias, KM Frey, KA Spasov, M Bollini, KS Anderson, ... Journal of the American Chemical Society 135 (44), 16705-16713, 2013 | 91 | 2013 |
| Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles’ heel of targeted therapy CD Sohl, MR Ryan, BB Luo, KM Frey, KS Anderson ACS chemical biology 10 (5), 1319-1329, 2015 | 74 | 2015 |
| Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to … KM Frey, J Liu, MN Lombardo, DB Bolstad, DL Wright, AC Anderson Journal of molecular biology 387 (5), 1298-1308, 2009 | 60 | 2009 |
| Crystal structures of HIV-1 reverse transcriptase with picomolar inhibitors reveal key interactions for drug design KM Frey, M Bollini, AC Mislak, JA Cisneros, R Gallardo-Macias, ... Journal of the American Chemical Society 134 (48), 19501-19503, 2012 | 56 | 2012 |
| Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase KM Frey, MN Lombardo, DL Wright, AC Anderson Journal of structural biology 170 (1), 93-97, 2010 | 55 | 2010 |
| Structure-based evaluation of non-nucleoside inhibitors with improved potency and solubility that target HIV reverse transcriptase variants KM Frey, DE Puleo, KA Spasov, M Bollini, WL Jorgensen, KS Anderson Journal of medicinal chemistry 58 (6), 2737-2745, 2015 | 52 | 2015 |
| Protein design algorithms predict viable resistance to an experimental antifolate SM Reeve, P Gainza, KM Frey, I Georgiev, BR Donald, AC Anderson Proceedings of the National Academy of Sciences 112 (3), 749-754, 2015 | 52 | 2015 |
| Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase JM Beierlein, KM Frey, DB Bolstad, PM Pelphrey, TM Joska, AE Smith, ... Journal of medicinal chemistry 51 (23), 7532-7540, 2008 | 47 | 2008 |
| Structure-Based Approach to the Development of Potent and Selective Inhibitors of Dihydrofolate Reductase from Cryptosporidium DB Bolstad, ESD Bolstad, KM Frey, DL Wright, AC Anderson Journal of medicinal chemistry 51 (21), 6839-6852, 2008 | 47 | 2008 |
| Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes K Viswanathan, KM Frey, EW Scocchera, BD Martin, PW Swain III, ... PloS one 7 (2), e29434, 2012 | 40 | 2012 |
| Picomolar inhibitors of HIV-1 reverse transcriptase: design and crystallography of naphthyl phenyl ethers WG Lee, KM Frey, R Gallardo-Macias, KA Spasov, M Bollini, KS Anderson, ... ACS Medicinal Chemistry Letters 5 (11), 1259-1262, 2014 | 39 | 2014 |
| Extension into the entrance channel of HIV-1 reverse transcriptase—Crystallography and enhanced solubility M Bollini, KM Frey, JA Cisneros, KA Spasov, K Das, JD Bauman, E Arnold, ... Bioorganic & medicinal chemistry letters 23 (18), 5209-5212, 2013 | 39 | 2013 |
| Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase–dihydrofolate reductase VP Kumar, JA Cisneros, KM Frey, A Castellanos-Gonzalez, Y Wang, ... Bioorganic & medicinal chemistry letters 24 (17), 4158-4161, 2014 | 32 | 2014 |
| Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance KM Frey, K Viswanathan, DL Wright, AC Anderson Antimicrobial agents and chemotherapy 56 (7), 3556-3562, 2012 | 31 | 2012 |
| Substituted pyrrolo [2, 3-d] pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors VP Kumar, KM Frey, Y Wang, HK Jain, A Gangjee, KS Anderson Bioorganic & medicinal chemistry letters 23 (19), 5426-5428, 2013 | 28 | 2013 |
| Development of 3D-printed layered PLGA films for drug delivery and evaluation of drug release behaviors I Serris, P Serris, KM Frey, H Cho AAPS PharmSciTech 21 (7), 256, 2020 | 25 | 2020 |
| Potent inhibitors active against HIV reverse transcriptase with K101P, a mutation conferring rilpivirine resistance WT Gray, KM Frey, SB Laskey, AC Mislak, KA Spasov, WG Lee, M Bollini, ... ACS Medicinal Chemistry Letters 6 (10), 1075-1079, 2015 | 24 | 2015 |
| Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase WG Lee, KM Frey, R Gallardo-Macias, KA Spasov, AH Chan, ... Bioorganic & medicinal chemistry letters 25 (21), 4824-4827, 2015 | 22 | 2015 |
| Limonene-induced activation of A 2A adenosine receptors reduces airway inflammation and reactivity in a mouse model of asthma PDS Patel M, Narke D, Kurade M, Frey KM, Rajalingam S, Siddiquee A, Mustafa ... Purinergic Signalling 16, 415-426, 2020 | 18 | 2020 |
