GPCR systems pharmacology: a different perspective on the development of biased therapeutics DS Eiger, U Pham, J Gardner, C Hicks, S Rajagopal American Journal of Physiology-Cell Physiology 322 (5), C887-C895, 2022 | 39 | 2022 |
Biased agonism at chemokine receptors DS Eiger, N Boldizsar, CC Honeycutt, J Gardner, S Rajagopal Cellular signalling 78, 109862, 2021 | 36 | 2021 |
Location bias contributes to functionally selective responses of biased CXCR3 agonists DS Eiger, N Boldizsar, CC Honeycutt, J Gardner, S Kirchner, C Hicks, ... Nature Communications 13 (1), 5846, 2022 | 33 | 2022 |
Phosphorylation barcodes direct biased chemokine signaling at CXCR3 DS Eiger, JS Smith, T Shi, TM Stepniewski, CF Tsai, C Honeycutt, ... Cell chemical biology 30 (4), 362-382. e8, 2023 | 16 | 2023 |
Location bias: a “hidden variable” in GPCR pharmacology DS Eiger, C Hicks, J Gardner, U Pham, S Rajagopal Bioessays 45 (11), 2300123, 2023 | 13 | 2023 |
GPCR kinases differentially modulate biased signaling downstream of CXCR3 depending on their subcellular localization J Gardner, DS Eiger, C Hicks, I Choi, U Pham, A Chundi, O Namjoshi, ... Science signaling 17 (823), eadd9139, 2024 | 7 | 2024 |
ACKR3 Proximity Labeling Identifies Novel G protein-and β-arrestin-independent GPCR Interacting Proteins C Hicks, J Gardner, DS Eiger, ND Camarda, U Pham, S Dhar, ... bioRxiv, 2024 | 1 | 2024 |
Subcellular localization of GPCR kinases differentially modulate biased signaling at CXCR3 J Gardner, DS Eiger, C Hicks, I Choi, U Pham, S Rajagopal bioRxiv, 2022.07. 11.499601, 2022 | 1 | 2022 |
Location-biased β-arrestin conformations direct GPCR signaling U Pham, A Chundi, TM Stępniewski, S Darbha, DS Eiger, S Gazula, ... bioRxiv, 2024 | | 2024 |
Advances in GPCRs: Structure, Mechanisms, Disease, and Pharmacology: GPCR systems pharmacology: a different perspective on the development of biased therapeutics DS Eiger, U Pham, J Gardner, C Hicks, S Rajagopal American Journal of Physiology-Cell Physiology 322 (5), C887, 2022 | | 2022 |
Phosphorylation barcode ensembles encoded by biased CXCR3 agonists direct non‐redundant chemokine signaling DS Eiger, J Smith, T Shi, TM Stepniewski, C Honeycutt, N Boldizsar, ... The FASEB Journal 36, 2022 | | 2022 |
Location Bias of G Protein‐Coupled Receptor Kinases Promotes Biased Signaling at CXCR3 CN Hicks, D Eiger, J Gardner, N Boldizsar, C Honeycutt, I Choi, ... The FASEB Journal 36, 2022 | | 2022 |
Location Bias Contributes to Functionally Selective Responses of Biased CXCR3 Agonists to Regulate Inflammation J Gardner, D Eiger, N Boldizsar, CC Honeycutt, S Kirchner, C Hicks, ... The FASEB Journal 36, 2022 | | 2022 |
LIMPING THROUGH A DIFFERENTIAL: AN UNCOMMON PRESENTATION TO A COMMON PEDIATRIC DIAGNOSIS J Smith, J Gardner, K Dreher, S Sanders JOURNAL OF INVESTIGATIVE MEDICINE 70 (1), 219-219, 2022 | | 2022 |
Differential GRK Recruitment and the Phosphorylation Barcode as a Mechanism for Biased Agonism at G Protein‐Coupled Receptors J Gardner, D Eiger, C Honeycutt, N Boldizsar, I Choi, S Rajagopal The FASEB Journal 35, 2021 | | 2021 |
Receptor Endocytosis as a Mechanism of Biased Agonism at CXCR3 N Boldizsar, D Eiger, C Honeycutt, J Gardner, S Rajagopal The FASEB Journal 35, 2021 | | 2021 |
Sympathetic and Parasympathetic Regulation of NF‐κB by GPCRs through the modulation of interactions between p65/RelA and the β‐arrestins C Honeycutt, D Eiger, N Boldizsar, J Gardner, S Rajagopal The FASEB Journal 35, 2021 | | 2021 |
MANUSCRIPT TITLE DS Eiger, U Pham, J Gardner, C Hicks, S Rajagopal, S Rajagopal | | |