Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase Y Shan, K Gnanasambandan, D Ungureanu, ET Kim, H Hammarén, ... Nature structural & molecular biology 21 (7), 579-584, 2014 | 168 | 2014 |
Whole-exome sequencing in evaluation of patients with venous thromboembolism EJ Lee, DJ Dykas, AD Leavitt, RM Camire, E Ebberink, P García de Frutos, ... Blood advances 1 (16), 1224-1237, 2017 | 69 | 2017 |
Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation SR Hubbard, K Gnanasambandan Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (10), 2166-2169, 2013 | 59 | 2013 |
The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617 K Gnanasambandan, A Magis, PP Sayeski Biochemistry 49 (46), 9972-9984, 2010 | 50 | 2010 |
A structure-function perspective of Jak2 mutations and implications for alternate drug design strategies: the road not taken K Gnanasambandan, PP Sayeski Current medicinal chemistry 18 (30), 4659-4673, 2011 | 41 | 2011 |
Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation J Sayyah, K Gnanasambandan, S Kamarajugadda, S Tsuda, ... Cellular signalling 23 (11), 1806-1815, 2011 | 9 | 2011 |
A shift in the salt bridge interaction of residues D620 and E621 mediates the constitutive activation of Jak2-H538Q/K539L K Gnanasambandan, AT Magis, PP Sayeski Molecular and cellular biochemistry 367, 125-140, 2012 | 7 | 2012 |
Hammaré n Y Shan, K Gnanasambandan, D Ungureanu, ET Kim H., Yamashita, K., Silvennoinen, O., Shaw, DE, and Hubbard, SR, 579-584, 2014 | 5 | 2014 |
Whole Exome Sequencing and Extended Thrombophilia Testing in Patients with Venous Thromboembolism LM Shevell, EJ Lee, R Dhodapkar, D Dykas, A Popa, D Ma, N Bar, ... Blood 132, 2506, 2018 | 1 | 2018 |
Jak2 Plays a Critical and Non-Redundant Role In Hematopoiesis throughout Pre-and Post-Natal Life S Park, K Gnanasambandan, PP Sayeski Blood, The Journal of the American Society of Hematology 116 (21), 2238-2238, 2010 | 1 | 2010 |
Atomic model for janus kinase-2 (jak2) and uses thereof S Hubbard, K Gnanasambandan, Y Shan US Patent App. 15/112,235, 2018 | | 2018 |
Phosphorylation of Y372 is critical for ligand mediated Jak2 tyrosine kinase activation K Gnanasambandan, J Sayyah, S Kamarajugudda, S Tsuda, ... The FASEB Journal 25, 558.1-558.1, 2011 | | 2011 |