| Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer S Shu, CY Lin, HH He, RM Witwicki, DP Tabassum, JM Roberts, ... Nature 529 (7586), 413-417, 2016 | 606 | 2016 |
| NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis JD Brown, CY Lin, Q Duan, G Griffin, AJ Federation, RM Paranal, S Bair, ... Molecular cell 56 (2), 219-231, 2014 | 603 | 2014 |
| Peroxisome proliferator–activated receptors as transcriptional nodal points and therapeutic targets JD Brown, J Plutzky Circulation 115 (4), 518-533, 2007 | 450 | 2007 |
| BET bromodomains mediate transcriptional pause release in heart failure P Anand, JD Brown, CY Lin, J Qi, R Zhang, PC Artero, MA Alaiti, J Bullard, ... Cell 154 (3), 569-582, 2013 | 423 | 2013 |
| A genetic variant associated with five vascular diseases is a distal regulator of endothelin-1 gene expression RM Gupta, J Hadaya, A Trehan, SM Zekavat, C Roselli, D Klarin, ... Cell 170 (3), 522-533. e15, 2017 | 419 | 2017 |
| In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice LW Koblan, MR Erdos, C Wilson, WA Cabral, JM Levy, ZM Xiong, ... Nature, 1-7, 2021 | 356 | 2021 |
| Mechanisms of VEGF (vascular endothelial growth factor) inhibitor–associated hypertension and vascular disease AK Pandey, EK Singhi, JP Arroyo, TA Ikizler, ER Gould, J Brown, ... Hypertension 71 (2), e1-e8, 2018 | 315 | 2018 |
| CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells JN Topper, MR DiChiara, JD Brown, AJ Williams, D Falb, T Collins, ... Proceedings of the National Academy of Sciences 95 (16), 9506-9511, 1998 | 249 | 1998 |
| Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue FW Kiefer, C Vernochet, P O'brien, S Spoerl, JD Brown, S Nallamshetty, ... Nature medicine 18 (6), 918-925, 2012 | 245 | 2012 |
| BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure Q Duan, S McMahon, P Anand, H Shah, S Thomas, HT Salunga, Y Huang, ... Science translational medicine 9 (390), eaah5084, 2017 | 229 | 2017 |
| The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism JH Lee, P Giannikopoulos, SA Duncan, J Wang, CT Johansen, JD Brown, ... Nature medicine 17 (7), 812-815, 2011 | 229 | 2011 |
| MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in … JD Brown, MR DiChiara, KR Anderson, MA Gimbrone, JN Topper Journal of Biological Chemistry 274 (13), 8797-8805, 1999 | 227 | 1999 |
| PPARs and their metabolic modulation: new mechanisms for transcriptional regulation? W Ahmed, O Ziouzenkova, J Brown, P Devchand, S Francis, M Kadakia, ... Journal of internal medicine 262 (2), 184-198, 2007 | 220 | 2007 |
| A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use S Liu, JD Brown, KJ Stanya, E Homan, M Leidl, K Inouye, P Bhargava, ... Nature 502 (7472), 550-554, 2013 | 219 | 2013 |
| PPARγ in the endothelium regulates metabolic responses to high-fat diet in mice T Kanda, JD Brown, G Orasanu, S Vogel, FJ Gonzalez, J Sartoretto, ... The Journal of clinical investigation 119 (1), 2008 | 197 | 2008 |
| Deletion of the α-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity WA Chutkow, AL Birkenfeld, JD Brown, HY Lee, DW Frederick, ... Diabetes 59 (6), 1424-1434, 2010 | 183 | 2010 |
| Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score M Carbone, A Nardi, S Flack, G Carpino, N Varvaropoulou, C Gavrila, ... The Lancet Gastroenterology & Hepatology 3 (9), 626-634, 2018 | 132 | 2018 |
| Cardiovascular effects of androgen deprivation therapy in prostate cancer: contemporary meta-analyses JR Hu, MS Duncan, AK Morgans, JD Brown, WC Meijers, MS Freiberg, ... Arteriosclerosis, thrombosis, and vascular biology 40 (3), e55-e64, 2020 | 119 | 2020 |
| Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism FW Kiefer, G Orasanu, S Nallamshetty, JD Brown, H Wang, P Luger, ... Endocrinology 153 (7), 3089-3099, 2012 | 117 | 2012 |
| BET bromodomain proteins regulate enhancer function during adipogenesis JD Brown, ZB Feldman, SP Doherty, JM Reyes, PB Rahl, CY Lin, ... Proceedings of the National Academy of Sciences 115 (9), 2144-2149, 2018 | 74 | 2018 |
