Pharmacogenomics knowledge for personalized medicine M Whirl‐Carrillo, EM McDonagh, JM Hebert, L Gong, K Sangkuhl, ... Clinical Pharmacology & Therapeutics 92 (4), 414-417, 2012 | 2057 | 2012 |
Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process K E Caudle, T E Klein, J M Hoffman, D J Muller, M Whirl-Carrillo, L Gong, ... Current drug metabolism 15 (2), 209-217, 2014 | 441 | 2014 |
The 100 000 Genomes Project: bringing whole genome sequencing to the NHS C Turnbull, RH Scott, E Thomas, L Jones, N Murugaesu, FB Pretty, ... Bmj 361, 2018 | 418 | 2018 |
100,000 genomes pilot on rare-disease diagnosis in health care—preliminary report 100,000 Genomes Project Pilot Investigators New England Journal of Medicine 385 (20), 1868-1880, 2021 | 384 | 2021 |
PanelApp crowdsources expert knowledge to establish consensus diagnostic gene panels AR Martin, E Williams, RE Foulger, S Leigh, LC Daugherty, O Niblock, ... Nature genetics 51 (11), 1560-1565, 2019 | 349 | 2019 |
Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics M Ghoussaini, E Mountjoy, M Carmona, G Peat, EM Schmidt, A Hercules, ... Nucleic acids research 49 (D1), D1311-D1320, 2021 | 338 | 2021 |
Open Targets Platform: supporting systematic drug–target identification and prioritisation D Ochoa, A Hercules, M Carmona, D Suveges, A Gonzalez-Uriarte, ... Nucleic acids research 49 (D1), D1302-D1310, 2021 | 311 | 2021 |
From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource EM McDonagh, M Whirl-Carrillo, Y Garten, RB Altman, TE Klein Biomarkers in medicine 5 (6), 795-806, 2011 | 206 | 2011 |
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for human leukocyte antigen B (HLA‐B) genotype and allopurinol dosing: 2015 update Y Saito, LK Stamp, KE Caudle, MS Hershfield, EM McDonagh, ... Clinical Pharmacology & Therapeutics 99 (1), 36-37, 2016 | 153 | 2016 |
The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor A Meiser, A Mueller, EL Wise, EM McDonagh, SJ Petit, N Saran, PC Clark, ... The Journal of Immunology 180 (10), 6713-6724, 2008 | 153 | 2008 |
PharmGKB summary: caffeine pathway CF Thorn, E Aklillu, EM McDonagh, TE Klein, RB Altman Pharmacogenetics and genomics 22 (5), 389-395, 2012 | 150 | 2012 |
PharmGKB summary: very important pharmacogene information for: N:-acetyltransferase 2 EM McDonagh, S Boukouvala, E Aklillu, DW Hein, RB Altman, TE Klein Pharmacogenetics and genomics 24 (8), 409-425, 2014 | 149 | 2014 |
Nomenclature for alleles of the thiopurine methyltransferase gene ML Appell, J Berg, J Duley, WE Evans, MA Kennedy, L Lennard, ... Pharmacogenetics and genomics 23 (4), 242-248, 2013 | 142 | 2013 |
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Rasburicase Therapy in the Context of G6PD Deficiency Genotype MV Relling, EM McDonagh, T Chang, KE Caudle, HL McLeod, CE Haidar, ... Clinical Pharmacology & Therapeutics 96 (2), 169-174, 2014 | 140 | 2014 |
CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3 A Mueller, A Meiser, EM McDonagh, JM Fox, SJ Petit, G Xanthou, ... Journal of Leucocyte Biology 83 (4), 875-882, 2008 | 133 | 2008 |
The next-generation Open Targets Platform: reimagined, redesigned, rebuilt D Ochoa, A Hercules, M Carmona, D Suveges, J Baker, C Malangone, ... Nucleic acids research 51 (D1), D1353-D1359, 2023 | 123 | 2023 |
Human genetics evidence supports two-thirds of the 2021 FDA-approved drugs D Ochoa, M Karim, M Ghoussaini, DG Hulcoop, EM McDonagh, I Dunham Nat Rev Drug Discov 21 (8), 551, 2022 | 98 | 2022 |
Whole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study K Ibañez, J Polke, RT Hagelstrom, E Dolzhenko, D Pasko, ERA Thomas, ... The Lancet Neurology 21 (3), 234-245, 2022 | 98 | 2022 |
Opportunities and challenges for molecular understanding of ciliopathies–the 100,000 genomes project G Wheway, Genomics England Research Consortium, HM Mitchison Frontiers in genetics 10, 127, 2019 | 90 | 2019 |
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Ivacaftor Therapy in the Context of CFTR Genotype JP Clancy, SG Johnson, SW Yee, EM McDonagh, KE Caudle, TE Klein, ... Clinical Pharmacology & Therapeutics 95 (6), 592-597, 2014 | 75 | 2014 |