| CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease S Yang, R Chang, H Yang, T Zhao, Y Hong, HE Kong, X Sun, Z Qin, P Jin, ... The Journal of clinical investigation 127 (7), 2719-2724, 2017 | 398 | 2017 |
| A huntingtin knockin pig model recapitulates features of selective neurodegeneration in Huntington’s disease S Yan, Z Tu, Z Liu, N Fan, H Yang, S Yang, W Yang, Y Zhao, Z Ouyang, ... Cell 173 (4), 989-1002. e13, 2018 | 331 | 2018 |
| Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos Z Tu, W Yang, S Yan, A Yin, J Gao, X Liu, Y Zheng, J Zheng, Z Li, S Yang, ... Scientific reports 7 (1), 42081, 2017 | 134 | 2017 |
| Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice S Yang, S Huang, MA Gaertig, XJ Li, S Li Neuron 81 (2), 349-365, 2014 | 112 | 2014 |
| Microglial activation in the pathogenesis of Huntington’s disease HM Yang, S Yang, SS Huang, BS Tang, JF Guo Frontiers in aging neuroscience 9, 193, 2017 | 110 | 2017 |
| CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys W Yang, Y Liu, Z Tu, C Xiao, S Yan, X Ma, X Guo, X Chen, P Yin, Z Yang, ... Cell research 29 (4), 334-336, 2019 | 77 | 2019 |
| Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear … S Huang, JJ Ling, S Yang, XJ Li, S Li Brain 134 (7), 1943-1958, 2011 | 68 | 2011 |
| MANF regulates hypothalamic control of food intake and body weight S Yang, H Yang, R Chang, P Yin, Y Yang, W Yang, S Huang, MA Gaertig, ... Nature communications 8 (1), 579, 2017 | 59 | 2017 |
| Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form H Yang, S Yang, L Jing, L Huang, L Chen, X Zhao, W Yang, Y Pan, P Yin, ... Nature communications 11 (1), 2582, 2020 | 55 | 2020 |
| Shortening the half-life of Cas9 maintains its gene editing ability and reduces neuronal toxicity S Yang, S Li, XJ Li Cell reports 25 (10), 2653-2659. e3, 2018 | 51 | 2018 |
| Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains P Yin, X Guo, W Yang, S Yan, S Yang, T Zhao, Q Sun, Y Liu, S Li, XJ Li Acta neuropathologica 137, 919-937, 2019 | 44 | 2019 |
| Large polyglutamine repeats cause muscle degeneration in SCA17 mice S Huang, S Yang, J Guo, S Yan, MA Gaertig, S Li, XJ Li Cell reports 13 (1), 196-208, 2015 | 43 | 2015 |
| Lack of RAN-mediated toxicity in Huntington’s disease knock-in mice S Yang, H Yang, L Huang, L Chen, Z Qin, S Li, XJ Li Proceedings of the National Academy of Sciences 117 (8), 4411-4417, 2020 | 36 | 2020 |
| Piperine ameliorates SCA17 neuropathology by reducing ER stress J Guo, Y Cui, Q Liu, Y Yang, Y Li, L Weng, B Tang, P Jin, XJ Li, S Yang, ... Molecular Neurodegeneration 13, 1-13, 2018 | 35 | 2018 |
| Molecular mechanisms underlying Spinocerebellar Ataxia 17 (SCA17) pathogenesis S Yang, XJ Li, S Li Rare Diseases 4 (1), e1223580, 2016 | 35 | 2016 |
| Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17 Q Liu, S Huang, P Yin, S Yang, J Zhang, L Jing, S Cheng, B Tang, XJ Li, ... Nature communications 11 (1), 1101, 2020 | 28 | 2020 |
| DYRK1A regulates Hap1–Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome J Xiang, S Yang, N Xin, MA Gaertig, RH Reeves, S Li, XJ Li Proceedings of the National Academy of Sciences 114 (7), E1224-E1233, 2017 | 28 | 2017 |
| MANF: a new player in the control of energy homeostasis, and beyond S Yang, S Li, XJ Li Frontiers in physiology 9, 1725, 2018 | 24 | 2018 |
| Synergistic toxicity of polyglutamine-expanded TATA-binding protein in glia and neuronal cells: therapeutic implications for spinocerebellar ataxia 17 Y Yang, S Yang, J Guo, Y Cui, B Tang, XJ Li, S Li Journal of Neuroscience 37 (38), 9101-9115, 2017 | 20 | 2017 |
| Phosphorylation of myelin regulatory factor by PRKG 2 mediates demyelination in Huntington's disease P Yin, Q Liu, Y Pan, W Yang, S Yang, W Wei, X Chen, Y Hong, D Bai, ... EMBO reports 21 (6), e49783, 2020 | 19 | 2020 |
Shihua LiJinan University在 jnu.edu.cn 的电子邮件经过验证
