Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design PJ Ogden, ED Kelsic, S Sinai, GM Church Science 366 (6469), 1139-1143, 2019 | 326 | 2019 |
Deep diversification of an AAV capsid protein by machine learning DH Bryant, A Bashir, S Sinai, NK Jain, PJ Ogden, PF Riley, GM Church, ... Nature Biotechnology 39 (6), 691-696, 2021 | 247 | 2021 |
Toward machine-guided design of proteins S Biswas, G Kuznetsov, PJ Ogden, NJ Conway, RP Adams, GM Church BioRxiv, 337154, 2018 | 40 | 2018 |
A liquid chromatography/mass spectrometry method for screening disulfide tethering fragments KK Hallenbeck, JL Davies, C Merron, P Ogden, E Sijbesma, C Ottmann, ... SLAS DISCOVERY: Advancing Life Sciences R&D 23 (2), 183-192, 2018 | 30 | 2018 |
Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production NK Jain, PJ Ogden, GM Church Elife 12, RP87730, 2024 | 4 | 2024 |
Deep Search: Next-Gen Strategies for Accelerating AAV Capsid Engineering E Kelsic, S Sinai, P Ogden, M Nowak, G Church MOLECULAR THERAPY 26 (5), 168-168, 2018 | 2 | 2018 |
Viral vectors exhibiting improved gene delivery properties GM Church, E Kelsic, P Ogden, S Sinai US Patent App. 17/055,318, 2021 | 1 | 2021 |
Systematic Functional Characterization of the AAV Capsid Fitness Landscape E Kelsic, P Ogden, G Church MOLECULAR THERAPY 26 (5), 29-29, 2018 | 1 | 2018 |
Methods and compositions for protein detection P Ogden, G Kuznetsov, S Lofgren, K Nudel, HC Lim, K Duffy, J Chang US Patent 12,037,706, 2024 | | 2024 |
Methods and compositions for protein detection P Ogden, G Kuznetsov, S Lofgren, K Nudel, HC Lim, K Duffy, J Chang US Patent 11,976,384, 2024 | | 2024 |
Inverting the Drug Discovery Funnel: In Vivo First Screening for mAb Blood-brain Barrier Penetration Yields Molecules with Novel Uptake Properties (P8-4.007) P Ogden, A Garcia, S Alioto, M Nichols, K Nudel, S Carroll, J Avera, ... Neurology 102 (17_supplement_1), 6315, 2024 | | 2024 |
Methods and compositions for protein detection P Ogden, G Kuznetsov, S Lofgren, K Nudel, HC Lim, K Duffy, J Chang US Patent App. 18/452,894, 2024 | | 2024 |
Viral capsid polypeptides E Kelsic, S Sinai, P Ogden, GM Church US Patent App. 17/774,306, 2023 | | 2023 |
VIRAL VECTORS WITH ENHANCED GENE INSERTION PROPERTIES GM Church, E KELSIC, P OGDEN, S SINAI | | 2022 |
Massively Parallel Deep Diversification of AAV Capsid Proteins by Machine Learning D Bryant, A Bashir, S Sinai, N Jain, P Ogden, P Riley, GM Church, ... MOLECULAR THERAPY 28 (4), 240-240, 2020 | | 2020 |
Viral vectors exhibiting improved gene delivery properties GM Church, E KELSIC, P OGDEN, S SINAI | | 2019 |
Machine-Guided Design of AAV Capsid Proteins with Experimentally Augmented Evolutionary Data S Sinai, E Kelsic, J Tan, N Jain, P Ogden, M Nowak, GM Church MOLECULAR THERAPY 27 (4), 52-52, 2019 | | 2019 |
Discovery of a Novel Frameshifted ORF within the AAV Capsid Gene E Kelsic, P Ogden, G Church MOLECULAR THERAPY 27 (4), 314-314, 2019 | | 2019 |
Computational Design of AAV Capsids Using Machine Learning Models Trained on Deep Mutational Libraries D Bryant, S Sinai, P Ogden, N Jain, A Bashir, L Colwell, E Kelsic, ... MOLECULAR THERAPY 27 (4), 96-96, 2019 | | 2019 |
Dissecting Protein Fitness Landscapes Using DNA Synthesis and Sequencing: Case Studies in AAV and Beyond P Ogden Harvard University, 2019 | | 2019 |