Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism. G Burgos-Barragan, N Wit, J Meiser, FA Dingler, M Pietzke, L Mulderrig, ... Nature 548 (7669), 549, 2017 | 291 | 2017 |
Functionally similar WRKY proteins regulate vacuolar acidification in petunia and hair development in Arabidopsis W Verweij, CE Spelt, M Bliek, M de Vries, N Wit, M Faraco, R Koes, ... The Plant Cell 28 (3), 786-803, 2016 | 141 | 2016 |
Development of a general aza-Cope reaction trigger applied to fluorescence imaging of formaldehyde in living cells KJ Bruemmer, RR Walvoord, TF Brewer, G Burgos-Barragan, N Wit, ... Journal of the American Chemical Society 139 (15), 5338-5350, 2017 | 125 | 2017 |
Increased formate overflow is a hallmark of oxidative cancer J Meiser, A Schuster, M Pietzke, J Vande Voorde, D Athineos, K Oizel, ... Nature communications 9 (1), 1368, 2018 | 100 | 2018 |
A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells TF Brewer, G Burgos-Barragan, N Wit, KJ Patel, CJ Chang Chemical Science, 2017 | 94 | 2017 |
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: Existence of an alternative E3 ligase PHL Krijger, KY Lee, N Wit, PCM van den Berk, X Wu, HP Roest, A Maas, ... DNA repair 10 (4), 438-444, 2011 | 81 | 2011 |
PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance PHL Krijger, PCM van den Berk, N Wit, P Langerak, JG Jansen, ... DNA repair 10 (10), 1051-1059, 2011 | 60 | 2011 |
Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage N Wit, OA Buoninfante, P van den Berk, JG Jansen, MA Hogenbirk, ... Nucleic acids research 43 (1), 282-294, 2015 | 52 | 2015 |
The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes BM Ortmann, N Burrows, IT Lobb, E Arnaiz, N Wit, PSJ Bailey, LH Jordon, ... Nature Genetics 53 (7), 1022-1035, 2021 | 47 | 2021 |
Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet light JG Jansen, P Temviriyanukul, N Wit, F Delbos, CA Reynaud, H Jacobs, ... Nucleic acids research 42 (17), 11071-11082, 2014 | 44 | 2014 |
Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+ Ung2 hybrid pathway PHL Krijger, A Tsaalbi‐Shtylik, N Wit, PCM van den Berk, N de Wind, ... European journal of immunology 43 (10), 2765-2770, 2013 | 37 | 2013 |
Amino acid dependent formaldehyde metabolism in mammals M Pietzke, G Burgos-Barragan, N Wit, J Tait-Mulder, D Sumpton, ... Communications Chemistry 3 (1), 78, 2020 | 20 | 2020 |
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production N Wit, E Gogola, JA West, T Vornbäumen, RV Seear, PSJ Bailey, ... Science Advances 9 (20), eadg2235, 2023 | 8 | 2023 |
A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis AS Dickson, T Pauzaite, E Arnaiz, BM Ortmann, JA West, N Volkmar, ... Nature Communications 14 (1), 4816, 2023 | 7 | 2023 |
Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis C Pereira, GA Arroyo-Martinez, MZ Guo, MS Downey, ER Kelly, KJ Grive, ... Elife 11, e68677, 2022 | 6 | 2022 |
The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination. PHL Krijger, N Wit, PCM van den Berk, H Jacobs PloS one 5 (12), e15236-e15236, 2010 | 4 | 2010 |
Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA N Wit, PHL Krijger, PC van den Berk, H Jacobs PloS one 6 (1), 2011 | 3 | 2011 |
Hypoxia drives HIF2-dependent macrophage cell cycle entry and susceptibility to lentiviral transduction B Meng, N Zhao, P Mlcochova, IATM Ferreira, BM Ortmann, T Davis, N Wit, ... bioRxiv, 2023.12. 15.571908, 2023 | 1 | 2023 |
Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response T Pauzaite, N Wit, RV Seear, JA Nathan bioRxiv, 2024.01. 10.574971, 2024 | | 2024 |
T6 Genome-wide mutagenesis screens identify regulators of cellular iron metabolism and ferroptosis AW Martinelli, N Wit, JA Nathan Thorax 78 (Suppl 4), A4-A4, 2023 | | 2023 |