Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase JL Jankowsky, DJ Fadale, J Anderson, GM Xu, V Gonzales, NA Jenkins, ... Human molecular genetics 13 (2), 159-170, 2004 | 1755 | 2004 |
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies JL Jankowsky, HH Slunt, T Ratovitski, NA Jenkins, NG Copeland, ... Biomolecular engineering 17 (6), 157-165, 2001 | 895 | 2001 |
Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease JL Jankowsky, T Melnikova, DJ Fadale, GM Xu, HH Slunt, V Gonzales, ... Journal of Neuroscience 25 (21), 5217-5224, 2005 | 633 | 2005 |
NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer’s disease H Lian, L Yang, A Cole, L Sun, ACA Chiang, SW Fowler, DJ Shim, ... Neuron 85 (1), 101-115, 2015 | 580 | 2015 |
Astrocyte-microglia cross talk through complement activation modulates amyloid pathology in mouse models of Alzheimer's disease H Lian, A Litvinchuk, ACA Chiang, N Aithmitti, JL Jankowsky, H Zheng Journal of Neuroscience 36 (2), 577-589, 2016 | 510 | 2016 |
Practical considerations for choosing a mouse model of Alzheimer’s disease JL Jankowsky, H Zheng Molecular neurodegeneration 12, 1-22, 2017 | 404 | 2017 |
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease ER Roy, B Wang, Y Wan, G Chiu, A Cole, Z Yin, NE Propson, Y Xu, ... The Journal of clinical investigation 130 (4), 1912-1930, 2020 | 338 | 2020 |
The role of cytokines and growth factors in seizures and their sequelae JL Jankowsky, PH Patterson Progress in neurobiology 63 (2), 125-149, 2001 | 330 | 2001 |
Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease JL Jankowsky, G Xu, D Fromholt, V Gonzales, DR Borchelt Journal of Neuropathology & Experimental Neurology 62 (12), 1220-1227, 2003 | 323 | 2003 |
Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis L Verret, JL Jankowsky, GM Xu, DR Borchelt, C Rampon Journal of Neuroscience 27 (25), 6771-6780, 2007 | 279 | 2007 |
Persistent amyloidosis following suppression of Aβ production in a transgenic model of Alzheimer disease JL Jankowsky, HH Slunt, V Gonzales, AV Savonenko, JC Wen, ... PLoS medicine 2 (12), e355, 2005 | 248 | 2005 |
Intracerebroventricular viral injection of the neonatal mouse brain for persistent and widespread neuronal transduction JY Kim, SD Grunke, Y Levites, TE Golde, JL Jankowsky JoVE (Journal of Visualized Experiments), e51863, 2014 | 217 | 2014 |
Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain P Chakrabarty, A Rosario, P Cruz, Z Siemienski, C Ceballos-Diaz, ... PloS one 8 (6), e67680, 2013 | 202 | 2013 |
APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1 JL Jankowsky, HH Slunt, V Gonzales, NA Jenkins, NG Copeland, ... Neurobiology of aging 25 (7), 885-892, 2004 | 185 | 2004 |
Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease HA Born, JY Kim, RR Savjani, P Das, YA Dabaghian, Q Guo, JW Yoo, ... Journal of Neuroscience 34 (11), 3826-3840, 2014 | 184 | 2014 |
Quaternary structure defines a large class of amyloid-β oligomers neutralized by sequestration P Liu, MN Reed, LA Kotilinek, MKO Grant, CL Forster, W Qiang, ... Cell reports 11 (11), 1760-1771, 2015 | 170 | 2015 |
Cytokine and growth factor involvement in long-term potentiation JL Jankowsky, PH Patterson Molecular and Cellular Neuroscience 14 (4-5), 273-286, 1999 | 162 | 1999 |
Rodent Aβ modulates the solubility and distribution of amyloid deposits in transgenic mice JL Jankowsky, LH Younkin, V Gonzales, DJ Fadale, HH Slunt, HA Lester, ... Journal of Biological Chemistry 282 (31), 22707-22720, 2007 | 150 | 2007 |
Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-β immunotherapy A Wang, P Das, RC Switzer, TE Golde, JL Jankowsky Journal of Neuroscience 31 (11), 4124-4136, 2011 | 148 | 2011 |
Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo JY Kim, RT Ash, C Ceballos‐Diaz, Y Levites, TE Golde, SM Smirnakis, ... European Journal of Neuroscience 37 (8), 1203-1220, 2013 | 142 | 2013 |