Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention EA Dennis, J Cao, YH Hsu, V Magrioti, G Kokotos Chemical reviews 111 (10), 6130-6185, 2011 | 1255 | 2011 |
Cytosolic group IVA and calcium-independent group VIA phospholipase A2s act on distinct phospholipid pools in zymosan-stimulated mouse peritoneal macrophages L Gil-de-Gómez, AM Astudillo, C Guijas, V Magrioti, G Kokotos, ... The Journal of Immunology 192 (2), 752-762, 2014 | 161 | 2014 |
Synthetic and Natural Inhibitors of Phospholipases A2: Their Importance for Understanding and Treatment of Neurological Disorders WY Ong, T Farooqui, G Kokotos, AA Farooqui ACS chemical neuroscience 6 (6), 814-831, 2015 | 133 | 2015 |
A Convenient One-Pot Conversion of-Protected Amino Acids and Peptides into Alcohols G Kokotos Synthesis 1990 (4), 299-301, 1990 | 130 | 1990 |
Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer E Barbayianni, E Kaffe, V Aidinis, G Kokotos Progress in lipid research 58, 76-96, 2015 | 127 | 2015 |
A general approach to the asymmetric synthesis of unsaturated lipidic α-amino acids. The first synthesis of α-aminoarachidonic acid G Kokotos, JM Padrón, T Martín, WA Gibbons, VS Martín American Chemical Society, 1998 | 127 | 1998 |
Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases V Magrioti, G Kokotos Expert opinion on therapeutic patents 20 (1), 1-18, 2010 | 124 | 2010 |
Enantiospecific synthesis of α-amino acid semialdehydes: a key step for the synthesis of unnatural unsaturated and saturated α-amino acids JM Padrón, G Kokotos, T Martı́n, T Markidis, WA Gibbons, VS Martı́n Tetrahedron: Asymmetry 9 (19), 3381-3394, 1998 | 121 | 1998 |
Selective one-pot conversion of carboxylic acids into alcohols G Kokotos, C Noula The Journal of Organic Chemistry 61 (20), 6994-6996, 1996 | 114 | 1996 |
Inhibition of Group IVA Cytosolic Phospholipase A2 by Novel 2-Oxoamides in Vitro, in Cells, and in Vivo G Kokotos, DA Six, V Loukas, T Smith, V Constantinou-Kokotou, ... Journal of medicinal chemistry 47 (14), 3615-3628, 2004 | 108 | 2004 |
Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis A Kalyvas, C Baskakis, V Magrioti, V Constantinou-Kokotou, D Stephens, ... Brain 132 (5), 1221-1235, 2009 | 107 | 2009 |
Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-Independent Phospholipase A2 G Kokotos, YH Hsu, JE Burke, C Baskakis, CG Kokotos, V Magrioti, ... Journal of medicinal chemistry 53 (9), 3602-3610, 2010 | 106 | 2010 |
Novel 2-Oxoamide Inhibitors of Human Group IVA Phospholipase A2 G Kokotos, S Kotsovolou, DA Six, V Constantinou-Kokotou, CC Beltzner, ... Journal of medicinal chemistry 45 (14), 2891-2893, 2002 | 103 | 2002 |
Structure−Activity Relationship of 2-Oxoamide Inhibition of Group IVA Cytosolic Phospholipase A2 and Group V Secreted Phospholipase A2 DA Six, E Barbayianni, V Loukas, V Constantinou-Kokotou, ... Journal of medicinal chemistry 50 (17), 4222-4235, 2007 | 98 | 2007 |
4-Substituted prolines as organocatalysts for aldol reactions E Bellis, G Kokotos Tetrahedron 61 (36), 8669-8676, 2005 | 95 | 2005 |
Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury R López-Vales, X Navarro, T Shimizu, C Baskakis, G Kokotos, ... Brain 131 (10), 2620-2631, 2008 | 92 | 2008 |
Synthesis and Study of a Lipophilic α-Keto Amide Inhibitor of Pancreatic Lipase A Chiou, T Markidis, V Constantinou-Kokotou, R Verger, G Kokotos Organic Letters 2 (3), 347-350, 2000 | 92 | 2000 |
Primary Amine‐Thioureas based on tert‐Butyl Esters of Natural Amino Acids as Organocatalysts for the Michael Reaction CG Kokotos, G Kokotos Advanced Synthesis & Catalysis 351 (9), 1355-1362, 2009 | 88 | 2009 |
Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release TL Yaksh, G Kokotos, CI Svensson, D Stephens, CG Kokotos, ... Journal of Pharmacology and Experimental Therapeutics 316 (1), 466-475, 2006 | 87 | 2006 |
Proline-modified poly (propyleneimine) dendrimers as catalysts for asymmetric aldol reactions E Bellis, G Kokotos Journal of Molecular Catalysis A: Chemical 241 (1-2), 166-174, 2005 | 86 | 2005 |