| Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating … P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, ... Archives of toxicology 87, 1315-1530, 2013 | 1418 | 2013 |
| Managing the challenge of chemically reactive metabolites in drug development BK Park, A Boobis, S Clarke, CEP Goldring, D Jones, JG Kenna, ... Nature Reviews Drug Discovery 10 (4), 292-306, 2011 | 490 | 2011 |
| Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label … G Middleton, P Silcocks, T Cox, J Valle, J Wadsley, D Propper, F Coxon, ... The Lancet Oncology 15 (8), 829-840, 2014 | 393 | 2014 |
| Idiosyncratic adverse drug reactions: current concepts J Uetrecht, DJ Naisbitt Pharmacological reviews 65 (2), 779-808, 2013 | 376 | 2013 |
| Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones DJ Naisbitt, M Britschgi, G Wong, J Farrell, JPH Depta, DW Chadwick, ... Molecular pharmacology 63 (3), 732-741, 2003 | 299 | 2003 |
| Human leukocyte antigen (HLA)‐B* 57: 01‐restricted activation of drug‐specific T cells provides the immunological basis for flucloxacillin‐induced liver injury MM Monshi, L Faulkner, A Gibson, RE Jenkins, J Farrell, CJ Earnshaw, ... Hepatology 57 (2), 727-739, 2013 | 273 | 2013 |
| Characterization of drug-specific T cells in lamotrigine hypersensitivity DJ Naisbitt, J Farrell, G Wong, J pH Depta, CC Dodd, JE Hopkins, ... Journal of allergy and clinical immunology 111 (6), 1393-1403, 2003 | 258 | 2003 |
| Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals B Schnyder, C Burkhart, K Schnyder-Frutig, S von Greyerz, DJ Naisbitt, ... The Journal of Immunology 164 (12), 6647-6654, 2000 | 256 | 2000 |
| Immune pathomechanism of drug hypersensitivity reactions WJ Pichler, DJ Naisbitt, BK Park Journal of allergy and clinical immunology 127 (3), S74-S81, 2011 | 238 | 2011 |
| The danger hypothesis—potential role in idiosyncratic drug reactions M Pirmohamed, DJ Naisbitt, F Gordon, BK Park Toxicology 181, 55-63, 2002 | 220 | 2002 |
| Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment DJ Naisbitt, SF Gordon, M Pirmohamed, BK Park Drug safety 23, 483-507, 2000 | 201 | 2000 |
| Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models RJ Weaver, EA Blomme, AE Chadwick, IM Copple, HHJ Gerets, ... Nature Reviews Drug Discovery 19 (2), 131-148, 2020 | 191 | 2020 |
| Challenges and approaches for the development of safer immunomodulatory biologics JG Sathish, S Sethu, MC Bielsky, L De Haan, NS French, K Govindappa, ... Nature Reviews Drug Discovery 12 (4), 306-324, 2013 | 186 | 2013 |
| Activation of T cells by carbamazepine and carbamazepine metabolites Y Wu, JP Sanderson, J Farrell, NS Drummond, A Hanson, E Bowkett, ... Journal of allergy and clinical immunology 118 (1), 233-241, 2006 | 173 | 2006 |
| Induction of metabolism-dependent and-independent neutrophil apoptosis by clozapine DP Williams, M Pirmohamed, DJ Naisbitt, JP Uetrecht, BK Park Molecular pharmacology 58 (1), 207-216, 2000 | 171 | 2000 |
| Cellular and molecular pathophysiology of cutaneous drug reactions WJ Pichler, N Yawalkar, M Britschgi, J Depta, I Strasser, S Schmid, ... American journal of clinical dermatology 3, 229-238, 2002 | 166 | 2002 |
| Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity DJ Naisbitt, SJ Hough, HJ Gill, M Pirmohamed, NR Kitteringham, BK Park British journal of pharmacology 126 (6), 1393-1407, 1999 | 164 | 1999 |
| Metabolic activation in drug allergies BK Park, DJ Naisbitt, SF Gordon, NR Kitteringham, M Pirmohamed Toxicology 158 (1-2), 11-23, 2001 | 163 | 2001 |
| Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation DJ Naisbitt, J Farrell, SF Gordon, JL Maggs, C Burkhart, WJ Pichler, ... Molecular pharmacology 62 (3), 628-637, 2002 | 162 | 2002 |
| Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism‐dependent haptenation and T‐cell proliferation in vivo DJ Naisbitt, SF Gordon, M Pirmohamed, C Burkhart, AE Cribb, WJ Pichler, ... British journal of pharmacology 133 (2), 295-305, 2001 | 161 | 2001 |
