| Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation A Lewis, K Mitsuya, D Umlauf, P Smith, W Dean, J Walter, M Higgins, ... Nature genetics 36 (12), 1291-1295, 2004 | 493 | 2004 |
| Co-evolution of X-chromosome inactivation and imprinting in mammals W Reik, A Lewis Nature Reviews Genetics 6 (5), 403-410, 2005 | 332 | 2005 |
| Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1 E Jaeger, S Leedham, A Lewis, S Segditsas, M Becker, PR Cuadrado, ... Nature genetics 44 (6), 699-703, 2012 | 290 | 2012 |
| Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche H Davis, S Irshad, M Bansal, H Rafferty, T Boitsova, C Bardella, E Jaeger, ... Nature medicine 21 (1), 62-70, 2015 | 284 | 2015 |
| The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing L Redrup, MR Branco, ER Perdeaux, C Krueger, A Lewis, F Santos, ... Oxford University Press for The Company of Biologists Limited 136 (4), 525-530, 2009 | 248 | 2009 |
| Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer IPM Tomlinson, LG Carvajal-Carmona, SE Dobbins, A Tenesa, AM Jones, ... PLoS genetics 7 (6), e1002105, 2011 | 239 | 2011 |
| How imprinting centres work A Lewis, W Reik Cytogenetic and genome research 113 (1-4), 81-89, 2006 | 236 | 2006 |
| Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions S Lopes, A Lewis, P Hajkova, W Dean, J Oswald, T Forné, A Murrell, ... Human Molecular Genetics 12 (3), 295-305, 2003 | 219 | 2003 |
| FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation R Babaei-Jadidi, N Li, A Saadeddin, B Spencer-Dene, A Jandke, ... Journal of Experimental Medicine 208 (2), 295-312, 2011 | 195 | 2011 |
| Genomic imprinting: CTCF protects the boundaries A Lewis, A Murrell Current Biology 14 (7), R284-R286, 2004 | 131 | 2004 |
| Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo A Lewis, K Green, C Dawson, L Redrup, KD Huynh, JT Lee, M Hemberger, ... Oxford University Press for The Company of Biologists Limited 133 (21), 4203 …, 2006 | 103 | 2006 |
| A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts SJ Leedham, P Rodenas-Cuadrado, K Howarth, A Lewis, S Mallappa, ... Gut 62 (1), 83-93, 2013 | 101 | 2013 |
| Five endometrial cancer risk loci identified through genome-wide association analysis THT Cheng, DJ Thompson, TA O'Mara, JN Painter, DM Glubb, S Flach, ... Nature genetics 48 (6), 667-674, 2016 | 99 | 2016 |
| The Apc1322T mouse develops severe polyposis associated with submaximal nuclear β-catenin expression P Pollard, M Deheragoda, S Segditsas, A Lewis, A Rowan, K Howarth, ... Gastroenterology 136 (7), 2204-2213. e13, 2009 | 80 | 2009 |
| Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution AM Baker, W Huang, XMM Wang, M Jansen, XJ Ma, J Kim, CM Anderson, ... Nature Communications 8 (1), 1998, 2017 | 78 | 2017 |
| Severe polyposis in Apc1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5 A Lewis, S Segditsas, M Deheragoda, P Pollard, R Jeffery, E Nye, ... Gut 59 (12), 1680-1686, 2010 | 74 | 2010 |
| CRISPR-Cas9 causes chromosomal instability and rearrangements in cancer cell lines, detectable by cytogenetic methods E Rayner, MA Durin, R Thomas, D Moralli, SM O'cathail, I Tomlinson, ... The CRISPR journal 2 (6), 406-416, 2019 | 64 | 2019 |
| Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines H Davis, A Lewis, A Behrens, I Tomlinson Gut 63 (5), 792-799, 2014 | 62 | 2014 |
| A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding A Lewis, L Freeman-Mills, E de la Calle-Mustienes, RM Giráldez-Pérez, ... Cell reports 8 (4), 983-990, 2014 | 54 | 2014 |
| Bone morphogenetic protein and Notch signalling crosstalk in poor‐prognosis, mesenchymal‐subtype colorectal cancer S Irshad, M Bansal, P Guarnieri, H Davis, A Al Haj Zen, B Baran, ... The Journal of Pathology 242 (2), 178-192, 2017 | 52 | 2017 |
