The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication CQ Sacramento, GR de Melo, CS de Freitas, N Rocha, LVB Hoelz, ... Scientific reports 7 (1), 40920, 2017 | 235 | 2017 |
Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo CS de Freitas, LM Higa, CQ Sacramento, AC Ferreira, PA Reis, ... PLoS neglected tropical diseases 13 (1), e0007072, 2019 | 104 | 2019 |
Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication AC Ferreira, PA Reis, CS de Freitas, CQ Sacramento, L Villas Bôas Hoelz, ... Antimicrobial agents and chemotherapy 63 (2), 10.1128/aac. 01389-18, 2019 | 89 | 2019 |
In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19 CQ Sacramento, N Fintelman-Rodrigues, JR Temerozo, APD Da Silva, ... Journal of Antimicrobial Chemotherapy 76 (7), 1874-1885, 2021 | 69 | 2021 |
Evaluation of 7-arylaminopyrazolo [1, 5-a] pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors LFSP Azeredo, JP Coutinho, VAP Jabor, PR Feliciano, MC Nonato, ... European Journal of Medicinal Chemistry 126, 72-83, 2017 | 69 | 2017 |
Quantitative structure-activity relationships of antioxidant phenolic compounds. LVB Hoelz, BAC Horta, JQ Araújo, MG Albuquerque, RB Alencastro, ... | 59 | 2010 |
Plasmodium Falciparum Dihydroorotate Dehydrogenase: A Drug Target against Malaria LVB Hoelz, FA Calil, MC Nonato, LCS Pinheiro, N Boechat Future Medicinal Chemistry 10 (15), 1853-1874, 2018 | 49 | 2018 |
Pyrroles as privileged scaffolds in the search for new potential HIV inhibitors MCAD Bianco, DILF Marinho, LVB Hoelz, MM Bastos, N Boechat Pharmaceuticals 14 (9), 893, 2021 | 45 | 2021 |
The in vitro antiviral activity of the anti-hepatitis C virus (HCV) drugs daclatasvir and sofosbuvir against SARS-CoV-2 CQ Sacramento, N Fintelman-Rodrigues, JR Temerozo, ... BioRxiv, 2020.06. 15.153411, 2020 | 35 | 2020 |
Structural and Functional Analysis of a Platelet-Activating Lysophosphatidylcholine of Trypanosoma cruzi F Gazos-Lopes, MM Oliveira, LVB Hoelz, DP Vieira, AF Marques, ... PLoS neglected tropical diseases 8 (8), e3077, 2014 | 35 | 2014 |
Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE) JQ Araújo, MA de Brito, LVB Hoelz, RB de Alencastro, HC Castro, ... European journal of medicinal chemistry 46 (1), 39-51, 2011 | 32 | 2011 |
Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors FF Silveira, JO de Souza, LVB Hoelz, VR Campos, VAP Jabor, ... European Journal of Medicinal Chemistry 209, 112941, 2021 | 28 | 2021 |
New pyrazolopyrimidine derivatives as Leishmania amazonensis arginase inhibitors LM Feitosa, ER da Silva, LVB Hoelz, DL Souza, JA Come, ... Bioorganic & Medicinal Chemistry 27 (14), 3061-3069, 2019 | 22 | 2019 |
Molecular dynamics simulations of the free and inhibitor-bound cruzain systems in aqueous solvent: insights on the inhibition mechanism in acidic pH LVB Hoelz, VF Leal, CR Rodrigues, PG Pascutti, MG Albuquerque, ... Journal of Biomolecular Structure and Dynamics 34 (9), 1969-1978, 2016 | 20 | 2016 |
Quimioterapia antileishmania: uma revisão da literatura MM Bastos, N Boechat, LVB Hoelz, AP de Oliveira Revista virtual de Química 8 (6), 2072-2104, 2016 | 19 | 2016 |
Imatinib derivatives as inhibitors of K562 cells in chronic myeloid leukemia LD Azevedo, MM Bastos, FC Vasconcelos, LVB Hoelz, FPS Junior, ... Medicinal Chemistry Research 26, 2929-2941, 2017 | 17 | 2017 |
Solvent Free, Microwave Assisted Conversion of Aldehydes into Nitriles and Oximes in the Presence of NH2OH·HCl and TiO2 LVB Hoelz, BT Gonçalves, JC Barros, JFM da Silva Molecules 15 (1), 94-99, 2009 | 17 | 2009 |
Kinetic resolution of (±)-1, 2-O-isopropylidene-3, 6-di-O-benzyl-myo-inositol by lipases: An experimental and theoretical study on the reaction of a key precursor of chiral … ABC Simas, AAT da Silva, AG Cunha, RS Assumpção, LVB Hoelz, ... Journal of Molecular Catalysis B: Enzymatic 70 (1-2), 32-40, 2011 | 16 | 2011 |
Synthesis, biological evaluation, and molecular modeling studies of new thiadiazole derivatives as potent P2X7 receptor inhibitors DTG Gonzaga, FH Oliveira, NL Ranke, GQ Pinho, JP Salles, ML Bello, ... Frontiers in Chemistry 7, 261, 2019 | 15 | 2019 |
New 1,2,3‐triazole‐based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations DI Leite, FV Fontes, MM Bastos, LVB Hoelz, MCAD Bianco, ... Chemical Biology & Drug Design 92 (3), 1670-1682, 2018 | 15 | 2018 |