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Shraddha Thakkar
Shraddha Thakkar
US FDA, Center for Drug Evaluation and Research
在 fda.hhs.gov 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Transparency and reproducibility in artificial intelligence
B Haibe-Kains, G Alexandru Adam, A Hosny, F Khodakarami, ...
Nature 586 (2020), pages E14–E16, 2020
3502020
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong
Drug discovery today 21 (4), 648-653, 2016
3042016
Reporting guidelines for human microbiome research: the STORMS checklist
C Mirzayi, A Renson, Genomic Standards Consortium, ...
Nature medicine 27 (11), 1885-1892, 2021
2222021
Regulatory landscape of dietary supplements and herbal medicines from a global perspective
S Thakkar, E Anklam, A Xu, F Ulberth, J Li, B Li, M Hugas, N Sarma, ...
Regulatory Toxicology and Pharmacology 114, 104647, 2020
1712020
Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity
S Thakkar, T Li, Z Liu, L Wu, R Roberts, W Tong
Drug discovery today, 2019
902019
Development of decision forest models for prediction of drug-induced liver injury in humans using a large set of FDA-approved drugs
H Hong, S Thakkar, M Chen, W Tong
Scientific reports 7 (1), 17311, 2017
832017
The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury
S Thakkar, M Chen, H Fang, Z Liu, R Roberts, W Tong
Expert review of gastroenterology & hepatology 12 (1), 31-38, 2018
592018
Comprehensive assessments of RNA-seq by the SEQC consortium: FDA-led efforts advance precision medicine
J Xu, B Gong, L Wu, S Thakkar, H Hong, W Tong
Pharmaceutics 8 (1), 8, 2016
582016
Synthesis and anti-cancer screening of novel heterocyclic-(2 H)-1, 2, 3-triazoles as potential anti-cancer agents
NR Penthala, L Madhukuri, S Thakkar, NR Madadi, G Lamture, RL Eoff, ...
MedChemComm 6 (8), 1535-1543, 2015
572015
Structure-based design targeted at LOX-1, a receptor for oxidized low-density lipoprotein
S Thakkar, X Wang, M Khaidakov, Y Dai, K Gokulan, JL Mehta, ...
Scientific reports 5 (1), 1-11, 2015
542015
DeepDILI: deep learning-powered drug-induced liver injury prediction using model-level representation
T Li, W Tong, R Roberts, Z Liu, S Thakkar
Chemical research in toxicology 34 (2), 550-565, 2020
532020
Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA
L Wu, T Ingle, Z Liu, A Zhao-Wong, S Harris, S Thakkar, G Zhou, J Yang, ...
BMC bioinformatics 20, 129-139, 2019
452019
Deep learning on high-throughput transcriptomics to predict drug-induced liver injury
T Li, W Tong, R Roberts, Z Liu, S Thakkar
Frontiers in bioengineering and biotechnology 8, 562677, 2020
312020
Molecular dynamics guided design of tocoflexol: a new radioprotectant tocotrienol with enhanced bioavailability
CM Compadre, A Singh, S Thakkar, G Zheng, PJ Breen, S Ghosh, M Kiaei, ...
Drug Development Research 75 (1), 10-22, 2014
302014
DeepCarc: Deep learning-powered carcinogenicity prediction using model-level representation
T Li, W Tong, R Roberts, Z Liu, S Thakkar
Frontiers in artificial intelligence 4, 757780, 2021
272021
Antioxidant tocols as radiation countermeasures (challenges to be addressed to use tocols as radiation countermeasures in humans)
U Nukala, S Thakkar, KJ Krager, PJ Breen, CM Compadre, N Aykin-Burns
Antioxidants 7 (2), 33, 2018
272018
Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering
S Thakkar, N Nanaware-Kharade, R Celikel, EC Peterson, KI Varughese
Scientific reports 4 (1), 3673, 2014
272014
Emerging technologies for food and drug safety
W Slikker Jr, TA de Souza Lima, D Archella, JB de Silva Junior, ...
Regulatory Toxicology and Pharmacology 98, 115-128, 2018
262018
Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents
NR Penthala, S Thakkar, PA Crooks
Bioorganic & medicinal chemistry letters 25 (14), 2763-2767, 2015
242015
Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
B Gong, D Li, R Kusko, N Novoradovskaya, Y Zhang, S Wang, ...
Genome biology 22, 1-23, 2021
222021
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