Old, new and emerging functions of caspases S Shalini, L Dorstyn, S Dawar, S Kumar Cell Death & Differentiation 22 (4), 526-539, 2015 | 1435 | 2015 |
DRONC, an ecdysone-inducible Drosophila caspase L Dorstyn, PA Colussi, LM Quinn, H Richardson, S Kumar Proceedings of the National Academy of Sciences 96 (8), 4307-4312, 1999 | 350 | 1999 |
The role of cytochrome c in caspase activation in Drosophila melanogaster cells L Dorstyn, S Read, D Cakouros, JR Huh, BA Hay, S Kumar The Journal of cell biology 156 (6), 1089-1098, 2002 | 241 | 2002 |
New insights into apoptosome structure and function L Dorstyn, CW Akey, S Kumar Cell Death & Differentiation 25 (7), 1194-1208, 2018 | 202 | 2018 |
An essential role for the caspase dronc in developmentally programmed cell death in Drosophila LM Quinn, L Dorstyn, K Mills, PA Colussi, P Chen, M Coombe, J Abrams, ... Journal of Biological Chemistry 275 (51), 40416-40424, 2000 | 197 | 2000 |
A tumor suppressor function for caspase-2 LH Ho, R Taylor, L Dorstyn, D Cakouros, P Bouillet, S Kumar Proceedings of the National Academy of Sciences 106 (13), 5336-5341, 2009 | 192 | 2009 |
DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7 L Dorstyn, SH Read, LM Quinn, H Richardson, S Kumar Journal of Biological Chemistry 274 (43), 30778-30783, 1999 | 168 | 1999 |
The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells L Dorstyn, K Mills, Y Lazebnik, S Kumar The Journal of Cell Biology 167 (3), 405-410, 2004 | 152 | 2004 |
Caspase-2 is required for cell death induced by cytoskeletal disruption LH Ho, SH Read, L Dorstyn, L Lambrusco, S Kumar Oncogene 27 (24), 3393-3404, 2008 | 143 | 2008 |
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2 NJ Foot, HE Dalton, LM Shearwin-Whyatt, L Dorstyn, SS Tan, B Yang, ... Blood, The Journal of the American Society of Hematology 112 (10), 4268-4275, 2008 | 142 | 2008 |
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons J Howitt, U Putz, J Lackovic, A Doan, L Dorstyn, H Cheng, B Yang, ... Proceedings of the National Academy of Sciences 106 (36), 15489-15494, 2009 | 130 | 2009 |
Characterization of the DrosophilaCaspase, DAMM NL Harvey, T Daish, K Mills, L Dorstyn, LM Quinn, SH Read, ... Journal of Biological Chemistry 276 (27), 25342-25350, 2001 | 111 | 2001 |
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability L Dorstyn, J Puccini, CH Wilson, S Shalini, M Nicola, S Moore, S Kumar Cell Death & Differentiation 19 (8), 1288-1298, 2012 | 109 | 2012 |
Caspase-2 as a tumour suppressor J Puccini, L Dorstyn, S Kumar Cell Death & Differentiation 20 (9), 1133-1139, 2013 | 104 | 2013 |
Structure of the Drosophila apoptosome at 6.9 Å resolution S Yuan, X Yu, M Topf, L Dorstyn, S Kumar, SJ Ludtke, CW Akey Structure 19 (1), 128-140, 2011 | 98 | 2011 |
Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice S Shalini, L Dorstyn, C Wilson, J Puccini, L Ho, S Kumar Cell Death & Differentiation 19 (8), 1370-1380, 2012 | 95 | 2012 |
Caspase-2-mediated cell death is required for deleting aneuploid cells S Dawar, Y Lim, J Puccini, M White, P Thomas, L Bouchier-Hayes, ... Oncogene 36 (19), 2704-2714, 2017 | 74 | 2017 |
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice J Puccini, S Shalini, AK Voss, M Gatei, CH Wilson, DK Hiwase, MF Lavin, ... Proceedings of the National Academy of Sciences 110 (49), 19920-19925, 2013 | 71 | 2013 |
A biochemical analysis of the activation of the Drosophila caspase DRONC L Dorstyn, S Kumar Cell Death & Differentiation 15 (3), 461-470, 2008 | 69 | 2008 |
ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis JJ Sandow, L Dorstyn, LA O'reilly, M Tailler, S Kumar, A Strasser, ... Cell Death & Differentiation 21 (3), 475-480, 2014 | 64 | 2014 |