Protein kinase G type Iα activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation EL Leung, JC Wong, MG Johlfs, BK Tsang, RR Fiscus Molecular Cancer Research 8 (4), 578-591, 2010 | 79 | 2010 |
Cyclic GMP/protein kinase G type‐Iα (PKG‐Iα) signaling pathway promotes CREB phosphorylation and maintains higher c‐IAP1, livin, survivin, and Mcl‐1 expression and the … JC Wong, M Bathina, RR Fiscus Journal of cellular biochemistry 113 (11), 3587-3598, 2012 | 74 | 2012 |
Essential roles of the nitric oxide (no)/cGMP/protein kinase G type‐Iα (PKG‐Iα) signaling pathway and the atrial natriuretic peptide (ANP)/cGMP/PKG‐Iα autocrine loop in … JC Wong, RR Fiscus Journal of cellular biochemistry 112 (3), 829-839, 2011 | 70 | 2011 |
Resveratrol at anti-angiogenesis/anticancer concentrations suppresses protein kinase G signaling and decreases IAPs expression in HUVECs JC Wong, RR Fiscus Anticancer research 35 (1), 273-281, 2015 | 61 | 2015 |
A glucocorticoid-and diet-responsive pathway toggles adipocyte precursor cell activity in vivo JC Wong, KC Krueger, MJ Costa, A Aggarwal, H Du, TL McLaughlin, ... Sci. Signal. 9 (451), ra103-ra103, 2016 | 36 | 2016 |
Protein kinase G activity prevents pathological-level nitric oxide-induced apoptosis and promotes DNA synthesis/cell proliferation in vascular smooth muscle cells JC Wong, RR Fiscus Cardiovascular Pathology 19 (6), e221-e231, 2010 | 24 | 2010 |
Protein Kinase G-Iα Hyperactivation and VASP Phosphorylation in Promoting Ovarian Cancer Cell Migration and Platinum Resistance JC Wong, RR Fiscus Ovarian Cancer-A Clinical and Translational Update: INTECH, 251-73, 2013 | 9 | 2013 |
Nitric Oxide/protein kinase G-Iα promotes c-Src activation, proliferation and chemoresistance in ovarian cancer RR Fiscus, EL Leung, JC Wong, MG Johlfs Ovarian Cancer-Basic Science Perspective (Farghaly S ed.): Intech Open …, 2012 | 7 | 2012 |
Ultrasensitive methodology for quantifying the kinase catalytic activity of any protein kinase in biological/clinical samples or recombinant/purified proteins using near … RR Fiscus, BFB Constantino, MG Johlfs, JC Wong US Patent App. 14/213,965, 2014 | 2 | 2014 |
Anti-Angiogenic and Anti-Cancer Effects by Targeting the Protein Kinase G Type-Iα (PKG-Iα) Signaling Pathway and its Downstream Effects on Expression of Inhibitor of Apoptosis … JC Wong, P Gorjala, B Costantino, RR Fiscus | 1 | 2016 |
Resveratrol causes biphasic apoptotic and proliferative effects and at higher/proapoptotic/anti-angiogenesis concentrations causes suppression of nitric oxide/cGMP/protein … JC Wong, R Coffman, H Rosenberg, RR Fiscus Cancer Research 74 (19 Supplement), 1008-1008, 2014 | | 2014 |
Resveratrol alters the kinase activity of PKG-Iα and Src family in A2780cp cells (ovarian cancer cell line with mutated p53) resulting in growth inhibition P Gorjala, JC Wong, BF Constantino, MG Johlfs, R Coffman, H Rosenberg, ... Cancer Research 74 (19 Supplement), 4558-4558, 2014 | | 2014 |
Role of PKG-I in differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs, OP9 cells) into lipid-accumulating fat cells through RhoA phosphorylation, IRS-1 and … P Gorjala, J Wong, B Constantino, M Johlfs, R Coffman, H Rosenberg, ... The FASEB Journal 28 (1 Supplement), 609.18, 2014 | | 2014 |
Advanced nano-proteomics based on ultrasensitive CE toquantitate protein expression/phosphorylation levels: Discovery of novel proteins involved in chemoresistance/invasion of … RR Fiscus, MG Johlfs, JC Wong, R Coffman, H Rosenberg Clinical Cancer Research 20 (2 Supplement), A29-A29, 2014 | | 2014 |
Essential Role Of The Nitric Oxide (no)/cGMP/protein Kinase G Type-Iα (pkg-Iα) Signaling Pathway In Survival And Insulin Secretion Of Pancreatic β-cells JC Wong, R Coffman, H Rosenberg, RR Fiscus Endocrine Practice 19 (1), 39A-40A, 2013 | | 2013 |
Protein kinase G type Iα activity in human ovarian cancer cells contributes to enhanced Src activation and DNA synthesis/cell proliferation JC Wong, EL Leung, MG Johlfs, BK Tsang, RR Fiscus Cancer Research 70 (8 Supplement), 1256-1256, 2010 | | 2010 |
Knockdown of the protein kinase G isoform PKG-Ialpha; using siRNA and shRNA significantly decreases cell proliferation and increases apoptosis in mesothelioma and prostate … R Fiscus, M Johlfs, J Wong, M Bathina, O Goodman, N Vogelzang CANCER RESEARCH 69 (9 Supplement), 2501-2501, 2009 | | 2009 |
Anti-apoptotic/cytoprotective effects of the nitric oxide/cGMP/protein kinase G signaling pathway in SV40-immortalized endothelial cells: implications for tumor angiogenesis CY Wong, R Fiscus, O Goodman, N Vogelzang Cancer Research 68 (9 Supplement), 2706-2706, 2008 | | 2008 |
Essential Role of the Nitric Oxide/Cyclic GMP/Protein Kinase G Signaling Pathway in Promoting Cell Survival (Chemoresistance) and Proliferation of Vascular Endothelial Cells … RR Fiscus, JC Wong, MG Johlfs, M Bathina, EL Leung, S Sharma, ... | | 2008 |
Mesothelioma and lung cancer cell lines differentially express the protein kinase G splice variants PKG-Iα and PKG-Iβ: Involvement in regulating apoptosis R Fiscus, M Johlfs, M Bathina, CY Wong, S Sharma, N Vogelzang Molecular Cancer Therapeutics 6 (11 Supplement), C182-C182, 2007 | | 2007 |