| The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model A Doran, RS Obach, BJ Smith, NA Hosea, S Becker, E Callegari, C Chen, ... Drug Metabolism and Disposition 33 (1), 165-174, 2005 | 520 | 2005 |
| Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy … CS Dias, AJ Shaywitz, SM Wasserman, BP Smith, B Gao, DS Stolman, ... Journal of the American College of Cardiology 60 (19), 1888-1898, 2012 | 310 | 2012 |
| Hydroxychloroquine concentration–response relationships in patients with rheumatoid arthritis T Munster, JP Gibbs, D Shen, BA Baethge, GR Botstein, J Caldwell, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2002 | 278 | 2002 |
| Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human MS Warren, N Zerangue, K Woodford, LM Roberts, EH Tate, B Feng, C Li, ... Pharmacological research 59 (6), 404-413, 2009 | 273 | 2009 |
| Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability … X Liu, BJ Smith, C Chen, E Callegari, SL Becker, X Chen, J Cianfrogna, ... Journal of Pharmacology and Experimental Therapeutics 313 (3), 1254-1262, 2005 | 219 | 2005 |
| Plasma concentration monitoring of busulfan: does it improve clinical outcome? JS McCune, JP Gibbs, JT Slattery Clinical pharmacokinetics 39, 155-165, 2000 | 195 | 2000 |
| Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. M Czerwinski, JP Gibbs, JT Slattery Drug metabolism and disposition 24 (9), 1015-1019, 1996 | 186 | 1996 |
| Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration X Liu, BJ Smith, C Chen, E Callegari, SL Becker, X Chen, J Cianfrogna, ... Drug metabolism and disposition 34 (9), 1443-1447, 2006 | 177 | 2006 |
| Quantitative prediction of human pharmacokinetics for monoclonal antibodies: retrospective analysis of monkey as a single species for first-in-human prediction JQ Dong, DH Salinger, CJ Endres, JP Gibbs, CP Hsu, BJ Stouch, E Hurh, ... Clinical pharmacokinetics 50, 131-142, 2011 | 156 | 2011 |
| Busulfan concentration and graft rejection in pediatric patients undergoing hematopoietic stem cell transplantation JS McCune, T Gooley, JP Gibbs, JE Sanders, EW Petersdorf, ... Bone marrow transplantation 30 (3), 167-173, 2002 | 136 | 2002 |
| The impact of obesity and disease on busulfan oral clearance in adults JP Gibbs, T Gooley, B Corneau, G Murray, P Stewart, FR Appelbaum, ... Blood, The Journal of the American Society of Hematology 93 (12), 4436-4440, 1999 | 120 | 1999 |
| Clinical pharmacokinetics and pharmacodynamics of evolocumab, a PCSK9 inhibitor S Kasichayanula, A Grover, MG Emery, MA Gibbs, R Somaratne, ... Clinical Pharmacokinetics 57, 769-779, 2018 | 115 | 2018 |
| Busulfan-Glutathione Conjugation Catalyzed by Human Liver Cytosolic Glutathione S-Transferases JP Gibbs, M Czerwinski, JT Slattery Cancer research 56 (16), 3678-3681, 1996 | 114 | 1996 |
| Up-regulation of glutathione S-transferase activity in enterocytes of young children JP Gibbs, CA Liacouras, RN Baldassano, JT Slattery Drug metabolism and disposition 27 (12), 1466-1469, 1999 | 110 | 1999 |
| Methods of treating or preventing cholesterol related disorders JCY Chan, JP Gibbs, CS Dias, S Wasserman, RAD Scott, CL Clogston, ... US Patent App. 13/469,032, 2013 | 99 | 2013 |
| Age-dependent tetrahydrothiophenium ion formation in young children and adults receiving high-dose busulfan JP Gibbs, G Murray, L Risler, JY Chien, R Dev, JT Slattery Cancer research 57 (24), 5509-5516, 1997 | 95 | 1997 |
| Developing exposure/response models for anticancer drug treatment: special considerations DR Mould, AC Walz, T Lave, JP Gibbs, B Frame CPT: pharmacometrics & systems pharmacology 4 (1), 12-27, 2015 | 88 | 2015 |
| Reaction phenotyping in drug discovery: moving forward with confidence? JA Williams, SI Hurst, J Bauman, BC Jones, R Hyland, JP Gibbs, ... Current drug metabolism 4 (6), 527-534, 2003 | 80 | 2003 |
| Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport JP Gibbs, MC Adeyeye, Z Yang, DD Shen Epilepsy research 58 (1), 53-66, 2004 | 74 | 2004 |
| Clinical pharmacology and translational aspects of bispecific antibodies A Trivedi, S Stienen, M Zhu, H Li, T Yuraszeck, J Gibbs, T Heath, ... Clinical and translational science 10 (3), 147, 2017 | 71 | 2017 |
