| Inhibitors of 17β-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challenges M Salah, AS Abdelsamie, M Frotscher Molecular and cellular endocrinology 489, 66-81, 2019 | 41 | 2019 |
| First dual inhibitors of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): designed multiple ligands as novel potential therapeutics for estrogen … M Salah, AS Abdelsamie, M Frotscher Journal of Medicinal Chemistry 60 (9), 4086-4092, 2017 | 33 | 2017 |
| Profiling of anabolic androgenic steroids and selective androgen receptor modulators for interference with adrenal steroidogenesis M Patt, KR Beck, T Di Marco, MC Jäger, V González-Ruiz, J Boccard, ... Biochemical pharmacology 172, 113781, 2020 | 22 | 2020 |
| Development of novel 2, 4-bispyridyl thiophene–based compounds as highly potent and selective Dyrk1A inhibitors. Part I: benzamide and benzylamide derivatives SS Darwish, M Abdel-Halim, M Salah, AH Abadi, W Becker, M Engel European Journal of Medicinal Chemistry 157, 1031-1050, 2018 | 22 | 2018 |
| Development of novel amide–derivatized 2, 4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a … SS Darwish, M Abdel-Halim, AK ElHady, M Salah, AH Abadi, W Becker, ... European Journal of Medicinal Chemistry 158, 270-285, 2018 | 19 | 2018 |
| Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study AS Abdelsamie, CJ van Koppen, E Bey, M Salah, C Börger, ... European Journal of Medicinal Chemistry 127, 944-957, 2017 | 19 | 2017 |
| First structure–activity relationship of 17β-hydroxysteroid dehydrogenase type 14 nonsteroidal inhibitors and crystal structures in complex with the enzyme F Braun, N Bertoletti, G Möller, J Adamski, T Steinmetzer, M Salah, ... Journal of Medicinal Chemistry 59 (23), 10719-10737, 2016 | 15 | 2016 |
| Dissolution testing and potentiometric determination of famciclovir in pure, dosage forms and biological fluids M Salah, RM El Nashar Bioelectrochemistry 89, 26-33, 2013 | 15 | 2013 |
| Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects YT AlNajjar, M Gabr, AK ElHady, M Salah, G Wilms, AH Abadi, W Becker, ... European Journal of Medicinal Chemistry 227, 113911, 2022 | 13 | 2022 |
| Design and synthesis of conformationally constraint Dyrk1A inhibitors by creating an intramolecular H-bond involving a benzothiazole core M Salah, M Abdel-Halim, M Engel Medchemcomm 9 (6), 1045-1053, 2018 | 11 | 2018 |
| Design, synthesis, and biological characterization of orally active 17β-hydroxysteroid dehydrogenase type 2 inhibitors targeting the prevention of osteoporosis AS Abdelsamie, M Salah, L Siebenbürger, A Merabet, C Scheuer, ... Journal of Medicinal Chemistry 62 (15), 7289-7301, 2019 | 9 | 2019 |
| Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design … AS Abdelsamie, M Salah, L Siebenbürger, MM Hamed, C Börger, ... European Journal of Medicinal Chemistry 178, 93-107, 2019 | 7 | 2019 |
| Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing AS Abdelsamie, S Herath, Y Biskupek, C Börger, L Siebenbürger, ... Journal of Medicinal Chemistry 62 (3), 1362-1372, 2019 | 7 | 2019 |
| Discovery of hydroxybenzothiazole urea compounds as multitargeted agents suppressing major cytotoxic mechanisms in neurodegenerative diseases Y Aboushady, M Gabr, AK ElHady, M Salah, AH Abadi, G Wilms, ... ACS Chemical Neuroscience 12 (22), 4302-4318, 2021 | 5 | 2021 |
| Synthesis and optimization of new 3, 6-disubstitutedindole derivatives and their evaluation as anticancer agents targeting the MDM2/MDMX complex MS Rezk, M Abdel-Halim, A Keeton, D Franklin, M Bauer, FM Boeckler, ... Chemical and Pharmaceutical Bulletin 64 (1), 34-41, 2016 | 4 | 2016 |
| Dual targeting of steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 by a novel drug-prodrug approach: A potential therapeutic option for the treatment of endometriosis A Mohamed, M Salah, M Tahoun, M Hawner, AS Abdelsamie, M Frotscher Journal of Medicinal Chemistry 65 (17), 11726-11744, 2022 | 3 | 2022 |
| Potent Dual Inhibitors of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle … M Salah, M Tahoun, J Rudzitis-Auth, L Stotz, CJ van Koppen, ... Journal of Medicinal Chemistry 66 (13), 8975-8992, 2023 | 1 | 2023 |
| Originally Designed Dyrk1a Inhibitors as Potent Dyrk1a/Clk1/Clk4/Haspin Multiple Inhibitors: Synthesis and Biological Activities of Sulfur-Containing Tetracycles A Faouzi, A Arnaud, F HALLE, J ROUSSEL, M AYMARD, V DENAVIT, ... | | |
