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Ruben Boon
Ruben Boon
Galapagos NV
在 glpg.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
K Vriens, S Christen, S Parik, D Broekaert, K Yoshinaga, A Talebi, ...
Nature 566 (7744), 403-406, 2019
3772019
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
W Guo, M Naujock, L Fumagalli, T Vandoorne, P Baatsen, R Boon, ...
Nature communications 8 (1), 861, 2017
3532017
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
I Elia, D Broekaert, S Christen, R Boon, E Radaelli, MF Orth, C Verfaillie, ...
Nature communications 8 (1), 15267, 2017
3442017
Breast cancer cells rely on environmental pyruvate to shape the metastatic niche
I Elia, M Rossi, S Stegen, D Broekaert, G Doglioni, M van Gorsel, R Boon, ...
Nature 568 (7750), 117-121, 2019
2532019
Generation of hepatic stellate cells from human pluripotent stem cells enables in vitro modeling of liver fibrosis
M Coll, L Perea, R Boon, SB Leite, J Vallverdú, I Mannaerts, A Smout, ...
Cell stem cell 23 (1), 101-113. e7, 2018
2042018
Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis
C Lange, M Turrero Garcia, I Decimo, F Bifari, G Eelen, A Quaegebeur, ...
The EMBO journal 35 (9), 924-941, 2016
1992016
Efficient recombinase-mediated cassette exchange in hPSCs to study the hepatocyte lineage reveals AAVS1 locus-mediated transgene inhibition
L Ordovás, R Boon, M Pistoni, Y Chen, E Wolfs, W Guo, R Sambathkumar, ...
Stem cell reports 5 (5), 918-931, 2015
1372015
Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines
R Boon, M Kumar, T Tricot, I Elia, L Ordovas, F Jacobs, J One, J De Smedt, ...
Nature communications 11 (1), 1393, 2020
1052020
SOX10 single transcription factor-based fast and efficient generation of oligodendrocytes from human pluripotent stem cells
JA García-León, M Kumar, R Boon, D Chau, J One, E Wolfs, K Eggermont, ...
Stem cell reports 10 (2), 655-672, 2018
1032018
Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways
JK Manesia, Z Xu, D Broekaert, R Boon, A van Vliet, G Eelen, ...
Stem cell research 15 (3), 715-721, 2015
842015
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors
D Lorendeau, G Rinaldi, R Boon, P Spincemaille, K Metzger, C Jäger, ...
Metabolic engineering 43, 187-197, 2017
792017
Nuclear metabolism and the regulation of the epigenome
R Boon, GG Silveira, R Mostoslavsky
Nature Metabolism 2 (11), 1190-1203, 2020
762020
Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2
C Claes, J Van Den Daele, R Boon, S Schouteden, A Colombo, ...
Alzheimer's & Dementia 15 (3), 453-464, 2019
712019
HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations
R Fazal, S Boeynaems, A Swijsen, M De Decker, L Fumagalli, M Moisse, ...
The EMBO journal 40 (7), e106177, 2021
692021
Stem cell-derived hepatocytes: A novel model for hepatitis E virus replication
N Helsen, Y Debing, J Paeshuyse, K Dallmeier, R Boon, M Coll, ...
Journal of Hepatology 64 (3), 565-573, 2016
602016
PU. 1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells
J De Smedt, EA van Os, I Talon, S Ghosh, B Toprakhisar, ...
Cell death & disease 12 (1), 84, 2021
272021
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma
JE Choi, C Sebastian, CM Ferrer, CA Lewis, M Sade-Feldman, T LaSalle, ...
Nature metabolism 3 (2), 182-195, 2021
262021
A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model
M Kumar, B Toprakhisar, M Van Haele, A Antoranz, R Boon, F Chesnais, ...
Biomaterials 276, 121006, 2021
222021
H3K27me3 does not orchestrate the expression of lineage-specific markers in hESC-derived hepatocytes in vitro
J Vanhove, M Pistoni, M Welters, K Eggermont, V Vanslembrouck, ...
Stem Cell Reports 7 (2), 192-206, 2016
222016
Metabolic fuel for epigenetic: nuclear production meets local consumption
R Boon
Frontiers in Genetics 12, 768996, 2021
202021
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