| ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy Y Shi, K Yamada, SA Liddelow, ST Smith, L Zhao, W Luo, RM Tsai, ... Nature 549 (7673), 523-527, 2017 | 1006 | 2017 |
| Structural conservation of ion conduction pathways in K channels and glutamate receptors. MW Wood, HM VanDongen, AM VanDongen Proceedings of the National Academy of Sciences 92 (11), 4882-4886, 1995 | 239 | 1995 |
| Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents M Bubser, TM Bridges, D Dencker, RW Gould, M Grannan, MJ Noetzel, ... ACS chemical neuroscience 5 (10), 920-942, 2014 | 136 | 2014 |
| The 5′-untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation MW Wood, HMA VanDongen, AMJ VanDongen Journal of Biological Chemistry 271 (14), 8115-8120, 1996 | 91 | 1996 |
| Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia MR Wood, MJ Noetzel, BJ Melancon, MS Poslusney, KD Nance, ... ACS medicinal chemistry letters 8 (2), 233-238, 2017 | 56 | 2017 |
| Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway J Fan, RQ Zhao, C Parro, W Zhao, HY Chou, J Robert, TZ Deeb, ... Journal of lipid research 59 (5), 830-842, 2018 | 48 | 2018 |
| An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor MW Wood, HMA VanDongen, AMJ VanDongen Journal of Biological Chemistry 272 (6), 3532-3537, 1997 | 47 | 1997 |
| Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154 RW Gould, MD Grannan, BW Gunter, J Ball, M Bubser, TM Bridges, ... Neuropharmacology 128, 492-502, 2018 | 44 | 2018 |
| Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models AJ Cross, D Widzowski, C Maciag, A Zacco, T Hudzik, J Liu, S Nyberg, ... British journal of pharmacology 173 (1), 155-166, 2016 | 43 | 2016 |
| 2, 6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity DG Brown, DL Maier, MA Sylvester, TN Hoerter, E Menhaji-Klotz, ... Bioorganic & medicinal chemistry letters 21 (11), 3399-3403, 2011 | 37 | 2011 |
| Challenges in the development of an M4 PAM in vivo tool compound: the discovery of VU0467154 and unexpected DMPK profiles of close analogs MR Wood, MJ Noetzel, MS Poslusney, BJ Melancon, JC Tarr, A Lamsal, ... Bioorganic & medicinal chemistry letters 27 (2), 171-175, 2017 | 34 | 2017 |
| Challenges in the development of an M4 PAM preclinical candidate: the discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides JC Tarr, MR Wood, MJ Noetzel, JL Bertron, RL Weiner, AL Rodriguez, ... Bioorganic & medicinal chemistry letters 27 (13), 2990-2995, 2017 | 32 | 2017 |
| Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5, 6-dimethyl-4-(piperidin-1-yl) thieno [2, 3-d] pyrimidine core MR Wood, MJ Noetzel, JL Engers, KA Bollinger, BJ Melancon, JC Tarr, ... Bioorganic & medicinal chemistry letters 26 (13), 3029-3033, 2016 | 32 | 2016 |
| Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides JC Tarr, MR Wood, MJ Noetzel, BJ Melancon, A Lamsal, VB Luscombe, ... Bioorganic & medicinal chemistry letters 27 (23), 5179-5184, 2017 | 28 | 2017 |
| Optimization of M4 positive allosteric modulators (PAMs): the discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology BJ Melancon, MR Wood, MJ Noetzel, KD Nance, EM Engelberg, C Han, ... Bioorganic & medicinal chemistry letters 27 (11), 2296-2301, 2017 | 28 | 2017 |
| State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154–relation to antipsychotic-like drug effects RW Gould, MT Nedelcovych, X Gong, E Tsai, M Bubser, TM Bridges, ... Neuropharmacology 102, 244-253, 2016 | 26 | 2016 |
| Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity DG Brown, PR Bernstein, Y Wu, RA Urbanek, CW Becker, SR Throner, ... ACS Medicinal Chemistry Letters 4 (1), 46-51, 2013 | 26 | 2013 |
| Identification of a chrysanthemic ester as an apolipoprotein E inducer in astrocytes J Fan, S Zareyan, W Zhao, Y Shimizu, TA Pfeifer, JH Tak, MB Isman, ... PloS one 11 (9), e0162384, 2016 | 24 | 2016 |
| A High-Throughput Functional Assay for Characterization of γ-Aminobutyric AcidA Channel Modulators Using Cryopreserved Transiently Transfected Cells J Liu, T Chen, T Norris, K Knappenberger, J Huston, M Wood, R Bostwick ASSAY and Drug Development Technologies 6 (6), 781-786, 2008 | 23 | 2008 |
| Alzheimer’s Disease Neuroimaging I, Fagan AM, Miller BL, Boxer AL, Seeley WW, Butovsky O, Barres BA, Paul SM, Holtzman DM (2017) ApoE4 markedly exacerbates tau-mediated … Y Shi, K Yamada, SA Liddelow, ST Smith, L Zhao, W Luo, RM Tsai, ... Nature 549, 523-527, 0 | 23 | |
