| Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals) M Schiedel, D Herp, S Hammelmann, S Swyter, A Lehotzky, D Robaa, ... Journal of medicinal chemistry 61 (2), 482-491, 2018 | 281 | 2018 |
| Selective Sirt2 inhibition by ligand-induced rearrangement of the active site T Rumpf, M Schiedel, B Karaman, C Roessler, BJ North, A Lehotzky, ... Nature communications 6 (1), 6263, 2015 | 270 | 2015 |
| The Current State of NAD+‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets M Schiedel, D Robaa, T Rumpf, W Sippl, M Jung Medicinal research reviews 38 (1), 147-200, 2018 | 130 | 2018 |
| Aminothiazoles as potent and selective Sirt2 inhibitors: a structure–activity relationship study M Schiedel, T Rumpf, B Karaman, A Lehotzky, J Oláh, S Gerhardt, J Ovádi, ... Journal of medicinal chemistry 59 (4), 1599-1612, 2016 | 89 | 2016 |
| Structure‐Based Development of an Affinity Probe for Sirtuin 2 M Schiedel, T Rumpf, B Karaman, A Lehotzky, S Gerhardt, J Ovádi, ... Angewandte Chemie International Edition 55 (6), 2252-2256, 2016 | 64 | 2016 |
| Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins C Falenczyk, M Schiedel, B Karaman, T Rumpf, N Kuzmanovic, M Grøtli, ... Chemical Science 5 (12), 4794-4799, 2014 | 64 | 2014 |
| A continuous, fluorogenic sirtuin 2 deacylase assay: substrate screening and inhibitor evaluation I Galleano, M Schiedel, M Jung, AS Madsen, CA Olsen Journal of medicinal chemistry 59 (3), 1021-1031, 2016 | 51 | 2016 |
| Small molecules as tools to study the chemical epigenetics of lysine acetylation M Schiedel, SJ Conway Current Opinion in Chemical Biology 45, 166-178, 2018 | 36 | 2018 |
| A chemical biology toolbox targeting the intracellular binding site of CCR9: fluorescent ligands, new drug leads and PROTACs ME Huber, L Toy, MF Schmidt, H Vogt, J Budzinski, MFJ Wiefhoff, ... Angewandte Chemie International Edition 61 (12), e202116782, 2022 | 31 | 2022 |
| Chemical epigenetics: the impact of chemical and chemical biology techniques on bromodomain target validation M Schiedel, M Moroglu, DMH Ascough, AER Chamberlain, JJAG Kamps, ... Angewandte Chemie International Edition 58 (50), 17930-17952, 2019 | 29 | 2019 |
| New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2 S Swyter, M Schiedel, D Monaldi, S Szunyogh, A Lehotzky, T Rumpf, ... Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018 | 29 | 2018 |
| BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability LE Jennings, M Schiedel, DS Hewings, S Picaud, CMC Laurin, PA Bruno, ... Bioorganic & Medicinal Chemistry 26 (11), 2937-2957, 2018 | 27 | 2018 |
| A facile synthesis of ligands for the von Hippel–Lindau E3 ligase C Steinebach, SA Voell, LP Vu, A Bricelj, I Sosič, G Schnakenburg, ... Synthesis 52 (17), 2521-2527, 2020 | 23 | 2020 |
| Fluorescence-Based Screening Assays for the NAD+-Dependent Histone Deacetylase smSirt2 from Schistosoma mansoni M Schiedel, M Marek, J Lancelot, B Karaman, I Almlöf, J Schultz, W Sippl, ... Journal of Biomolecular Screening 20 (1), 112-121, 2015 | 22 | 2015 |
| Modulation of microtubule acetylation by the interplay of TPPP/p25, SIRT2 and new anticancer agents with anti-SIRT2 potency A Szabó, J Oláh, S Szunyogh, A Lehotzky, T Szénási, M Csaplár, ... Scientific Reports 7 (1), 17070, 2017 | 21 | 2017 |
| HaloTag‐Targeted Sirtuin‐Rearranging Ligand (SirReal) for the Development of Proteolysis‐Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2) M Schiedel, A Lehotzky, S Szunyogh, J Oláh, S Hammelmann, N Wössner, ... Chembiochem 21 (23), 3371-3376, 2020 | 17 | 2020 |
| Controlling intramolecular interactions in the design of selective, high-affinity ligands for the CREBBP bromodomain M Brand, J Clayton, M Moroglu, M Schiedel, S Picaud, JP Bluck, ... Journal of medicinal chemistry 64 (14), 10102-10123, 2021 | 16 | 2021 |
| Fluorescent ligands targeting the intracellular allosteric binding site of the chemokine receptor CCR2 L Toy, ME Huber, MF Schmidt, D Weikert, M Schiedel ACS Chemical Biology 17 (8), 2142-2152, 2022 | 14 | 2022 |
| Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi CMC Laurin, JP Bluck, AKN Chan, M Keller, A Boczek, AR Scorah, ... ACS Infectious Diseases 7 (8), 2238-2249, 2020 | 13 | 2020 |
| Selective Sirt2 inhibition by ligand-induced rearrangement of the active site Nat T Rumpf, M Schiedel, B Karaman, C Roessler, BJ North, A Lehotzky, ... Commun 6 (6263), 10.1038, 2015 | 11 | 2015 |
