The widespread role of non-enzymatic reactions in cellular metabolism MA Keller, G Piedrafita, M Ralser Current opinion in biotechnology 34, 153-161, 2015 | 153 | 2015 |
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium B Colom, MP Alcolea, G Piedrafita, MWJ Hall, A Wabik, SC Dentro, ... Nature genetics 52 (6), 604-614, 2020 | 132 | 2020 |
Mutant clones in normal epithelium outcompete and eliminate emerging tumours B Colom, A Herms, MWJ Hall, SC Dentro, C King, RK Sood, MP Alcolea, ... Nature 598 (7881), 510-514, 2021 | 122 | 2021 |
Outcompeting p53-mutant cells in the normal esophagus by redox manipulation D Fernandez-Antoran, G Piedrafita, K Murai, SH Ong, A Herms, C Frezza, ... Cell stem cell 25 (3), 329-341. e6, 2019 | 103 | 2019 |
The impact of non-enzymatic reactions and enzyme promiscuity on cellular metabolism during (oxidative) stress conditions G Piedrafita, MA Keller, M Ralser Biomolecules 5 (3), 2101-2122, 2015 | 97 | 2015 |
Epidermal tissue adapts to restrain progenitors carrying clonal p53 mutations K Murai, G Skrupskelyte, G Piedrafita, M Hall, V Kostiou, SH Ong, T Nagy, ... Cell stem cell 23 (5), 687-699. e8, 2018 | 91 | 2018 |
A simple self-maintaining metabolic system: robustness, autocatalysis, bistability G Piedrafita, F Montero, F Moran, ML Cardenas, A Cornish-Bowden PLoS computational biology 6 (8), e1000872, 2010 | 79 | 2010 |
A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice G Piedrafita, V Kostiou, A Wabik, B Colom, D Fernandez-Antoran, ... Nature communications 11 (1), 1429, 2020 | 69 | 2020 |
Allele-specific gene expression is widespread across the genome and biological processes R Palacios, E Gazave, J Goni, G Piedrafita, O Fernando, A Navarro, ... PLoS One 4 (1), e4150, 2009 | 64 | 2009 |
Nonenzymatic gluconeogenesis-like formation of fructose 1, 6-bisphosphate in ice CB Messner, PC Driscoll, G Piedrafita, MFL De Volder, M Ralser Proceedings of the National Academy of Sciences 114 (28), 7403-7407, 2017 | 60 | 2017 |
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth E Abby, SC Dentro, MWJ Hall, JC Fowler, SH Ong, R Sood, A Herms, ... Nature Genetics 55 (2), 232-245, 2023 | 49 | 2023 |
Permeability-driven selection in a semi-empirical protocell model: the roots of prebiotic systems evolution G Piedrafita, PA Monnard, F Mavelli, K Ruiz-Mirazo Scientific reports 7 (1), 3141, 2017 | 33 | 2017 |
Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach G Piedrafita, K Ruiz-Mirazo, PA Monnard, A Cornish-Bowden, F Montero PLos one 7 (6), e39480, 2012 | 32 | 2012 |
Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure G Piedrafita, SJ Varma, C Castro, CB Messner, L Szyrwiel, JL Griffin, ... PLoS Biology 19 (12), e3001468, 2021 | 18 | 2021 |
Size matters: influence of stochasticity on the self-maintenance of a simple model of metabolic closure G Piedrafita, A Cornish-Bowden, F Morán, F Montero Journal of theoretical biology 300, 143-151, 2012 | 17 | 2012 |
Simulating a model of metabolic closure A Cornish-Bowden, G Piedrafita, F Morán, ML Cárdenas, F Montero Biological Theory 8, 383-390, 2013 | 16 | 2013 |
Stochastic simulations of mixed-lipid compartments: from self-assembling vesicles to self-producing protocells K Ruiz-Mirazo, G Piedrafita, F Ciriaco, F Mavelli Software Tools and Algorithms for Biological Systems, 689-696, 2011 | 12 | 2011 |
Levelling out differences in aerobic glycolysis neutralizes the competitive advantage of oncogenic PIK3CA mutant progenitors in the esophagus A Herms, B Colom, G Piedrafita, K Murai, SH Ong, D Fernandez-Antoran, ... bioRxiv, 2021.05. 28.446104, 2021 | 8 | 2021 |
Identifying ultrasensitive HGF dose-response functions in a 3D mammalian system for synthetic morphogenesis VR Senthivel, M Sturrock, G Piedrafita, M Isalan Scientific Reports 6 (1), 39178, 2016 | 8 | 2016 |
¿Qué es la vida? ML Cárdenas, G Piedrafita, F Montero, A Cornish-Bowden SEBBM 175, 14-16, 2013 | 5 | 2013 |