2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism KA Fader, R Nault, C Zhang, K Kumagai, JR Harkema, TR Zacharewski Scientific Reports 7, 2017 | 72 | 2017 |
Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis R Nault, KA Fader, DA Ammendolia, P Dornbos, D Potter, B Sharratt, ... Toxicological Sciences, kfw163, 2016 | 70 | 2016 |
Lipidomic evaluation of aryl hydrocarbon receptor-mediated hepatic steatosis in male and female mice by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. R Nault, KA Fader, TA Lydic, TR Zacharewski Chemical research in toxicology, 2017 | 58* | 2017 |
2, 3, 7, 8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice KA Fader, R Nault, DA Ammendolia, JR Harkema, KJ Williams, ... Toxicological Sciences, kfv206, 2015 | 55 | 2015 |
Single-nuclei RNA sequencing assessment of the hepatic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin R Nault, KA Fader, S Bhattacharya, TR Zacharewski Cellular and Molecular Gastroenterology and Hepatology 11 (1), 147-159, 2021 | 54 | 2021 |
Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells N Kovalova, R Nault, R Crawford, TR Zacharewski, NE Kaminski Toxicology and Applied Pharmacology 316, 95-106, 2017 | 52 | 2017 |
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice KA Fader, R Nault, CM Doskey, RR Fling, TR Zacharewski Scientific reports 9 (1), 1-18, 2019 | 49 | 2019 |
Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2, 3, 7, 8-Tetrachlorodibenzo-p-Dioxin R Nault, KA Fader, MP Kirby, S Ahmed, J Matthews, AD Jones, SY Lunt, ... Toxicological Sciences, kfv245, 2015 | 47 | 2015 |
Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity KA Fader, R Nault, MP Kirby, G Markous, J Matthews, TR Zacharewski Toxicology and Applied Pharmacology 321, 1-17, 2017 | 45 | 2017 |
Comparisons of differential gene expression elicited by TCDD, PCB126, βNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver R Nault, AL Forgacs, E Dere, TR Zacharewski Toxicology letters 223 (1), 52-59, 2013 | 41 | 2013 |
Ozone-Induced Type 2 Immunity in Nasal Airways: Development and Lymphoid Cell Dependence in Mice CB Ong, K Kumagai, PT Brooks, C Brandenberger, RP Lewandowski, ... American journal of respiratory cell and molecular biology, 2015 | 39 | 2015 |
RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice R Nault, KA Fader, T Zacharewski BMC genomics 16 (1), 373, 2015 | 39 | 2015 |
From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis R Nault, KA Fader, AK Kopec, JR Harkema, TR Zacharewski, ... Toxicological Sciences 154 (2), 381-391, 2016 | 37 | 2016 |
Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism N Joshi, AK Kopec, JL Ray, H Cline-Fedewa, A Nawabi, T Schmitt, ... Blood, blood-2015-09-670703, 2016 | 37 | 2016 |
Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice R Nault, KA Fader, JR Harkema, T Zacharewski PloS one 12 (9), e0184842, 2017 | 35 | 2017 |
Development of a Computational High-Throughput Tool for the Quantitative Examination of Dose-Dependent Histological Features R Nault, D Colbry, C Brandenberger, JR Harkema, TR Zacharewski Toxicologic pathology, 0192623314544379, 2014 | 30 | 2014 |
Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague–Dawley rats and C57BL/6 mice R Nault, S Kim, TR Zacharewski Toxicology and applied pharmacology 267 (2), 184-191, 2013 | 30 | 2013 |
Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57bl/6 mice AK Kopec, DR Boverhof, R Nault, JR Harkema, C Tashiro, D Potter, ... toxicological sciences, kft156, 2013 | 26 | 2013 |
Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin–Treated Mice Demonstrates NRF2-Independent PKM2 Induction R Nault, CM Doskey, KA Fader, CE Rockwell, T Zacharewski Molecular pharmacology 94 (2), 876-884, 2018 | 22 | 2018 |
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice RR Fling, CM Doskey, KA Fader, R Nault, TR Zacharewski Scientific reports 10 (1), 1-15, 2020 | 20 | 2020 |