| Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes J Musa, F Cidre-Aranaz, MM Aynaud, MF Orth, MML Knott, O Mirabeau, ... Nature communications 10 (1), 4128, 2019 | 61 | 2019 |
| Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma A Marchetto, S Ohmura, MF Orth, MML Knott, MV Colombo, C Arrigoni, ... Nature communications 11 (1), 2423, 2020 | 45 | 2020 |
| Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies MML Knott, TLB Hölting, S Ohmura, T Kirchner, F Cidre-Aranaz, ... Cancer and Metastasis Reviews 38, 625-642, 2019 | 41 | 2019 |
| Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma S Ohmura, A Marchetto, MF Orth, J Li, S Jabar, A Ranft, E Vinca, ... Molecular Cancer 20, 1-7, 2021 | 32 | 2021 |
| Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients G Sannino, A Marchetto, A Ranft, S Jabar, C Zacherl, R Alba-Rubio, ... EBioMedicine 47, 156-162, 2019 | 31 | 2019 |
| Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma M Dallmayer, J Li, S Ohmura, R Alba Rubio, MC Baldauf, TLB Hölting, ... Cell death & disease 10 (2), 116, 2019 | 29 | 2019 |
| High specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG positive Ewing sarcoma MF Orth, TLB Hölting, M Dallmayer, FS Wehweck, T Paul, J Musa, ... Cancers 12 (3), 644, 2020 | 23 | 2020 |
| Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer J Li, S Ohmura, A Marchetto, MF Orth, R Imle, M Dallmayer, J Musa, ... Nature Communications 12 (1), 5356, 2021 | 15 | 2021 |
| Integrative clinical transcriptome analysis reveals TMPRSS2‐ERG dependency of prognostic biomarkers in prostate adenocarcinoma JS Gerke, MF Orth, Y Tolkach, L Romero‐Pérez, FS Wehweck, S Stein, ... International journal of cancer 146 (7), 2036-2046, 2020 | 13 | 2020 |
| Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma MF Orth, JS Gerke, T Knösel, A Altendorf‐Hofmann, J Musa, ... International journal of cancer 144 (4), 859-867, 2019 | 13 | 2019 |
| Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. Nat Commun 10: 4128 J Musa, F Cidre-Aranaz, MM Aynaud, MF Orth, MML Knott, O Mirabeau, ... | 6 | 2019 |
| Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma F Cidre-Aranaz, J Li, TLB Hölting, MF Orth, R Imle, S Kutschmann, ... Molecular Cancer 21, 1-7, 2022 | 4 | 2022 |
| Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma TLB Hölting, F Cidre-Aranaz, D Matzek, B Popper, SJ Jacobi, CM Funk, ... Molecular Cancer 21 (1), 199, 2022 | 3 | 2022 |
| Analysis of regulatory DNA sequences by dual-luciferase reporter assays in ewing sarcoma TLB Hölting, MML Knott Ewing Sarcoma: Methods and Protocols, 139-149, 2021 | 2 | 2021 |
| Oncogenic hijacking of a developmental transcription factor evokes therapeutic vulnerability for ROS-induction in Ewing sarcoma A Marchetto, S Ohmura, MF Orth, J Li, FS Wehweck, MML Knott, S Stein, ... BioRxiv, 578666, 2019 | 2 | 2019 |
| Harnessing fusion transcription factors for specific gene therapy in childhood sarcoma models T Hölting lmu, 2024 | | 2024 |
| Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibition CM Funk, AC Ehlers, MF Orth, K Aljakouch, J Li, TLB Hölting, R Will, ... bioRxiv, 2022.12. 11.519935, 2022 | | 2022 |
| Convergent genetic mechanisms drive EIF4EBP1 overexpression, translational deregulation and tumorigenesis in Ewing sarcoma C Funk, MF Orth, K Aljakouch, J Li, R Imle, L Romero-Perez, TLB Hoelting, ... ONCOLOGY RESEARCH AND TREATMENT 45 (SUPPL 3), 234-235, 2022 | | 2022 |
| Publisher Correction: Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma A Marchetto, S Ohmura, MF Orth, MML Knott, MV Colombo, C Arrigoni, ... Nature communications 11, 2020 | | 2020 |
