Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases BT Greenhagen, PE O’Maille, JP Noel, J Chappell Proceedings of the National Academy of Sciences 103 (26), 9826-9831, 2006 | 252 | 2006 |
Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases PE O'maille, A Malone, N Dellas, B Andes Hess Jr, L Smentek, I Sheehan, ... Nature chemical biology 4 (10), 617-623, 2008 | 219 | 2008 |
Structural and Functional Analysis of the Pyocyanin Biosynthetic Protein PhzM from Pseudomonas aeruginosa, JF Parsons, BT Greenhagen, K Shi, K Calabrese, H Robinson, JE Ladner Biochemistry 46 (7), 1821-1828, 2007 | 159 | 2007 |
Metabolic engineering of sesquiterpene metabolism in yeast S Takahashi, Y Yeo, BT Greenhagen, T McMullin, L Song, ... Biotechnology and bioengineering 97 (1), 170-181, 2007 | 154 | 2007 |
Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio-and stereo-specific hydroxylations of diverse sesquiterpene substrates S Takahashi, YS Yeo, Y Zhao, PE O'Maille, BT Greenhagen, JP Noel, ... Journal of Biological Chemistry 282 (43), 31744-31754, 2007 | 143 | 2007 |
Crystal structure of the pyocyanin biosynthetic protein PhzS BT Greenhagen, K Shi, H Robinson, S Gamage, AK Bera, JE Ladner, ... Biochemistry 47 (19), 5281-5289, 2008 | 99 | 2008 |
Molecular scaffolds for chemical wizardry: learning nature's rules for terpene cyclases B Greenhagen, J Chappell Proceedings of the National Academy of Sciences 98 (24), 13479-13481, 2001 | 79 | 2001 |
Kinetic and molecular analysis of 5-epiaristolochene 1, 3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes S Takahashi, Y Zhao, PE O'Maille, BT Greenhagen, JP Noel, RM Coates, ... Journal of Biological Chemistry 280 (5), 3686-3696, 2005 | 59 | 2005 |
Surrogate splicing for functional analysis of sesquiterpene synthase genes S Wu, MA Schoenbeck, BT Greenhagen, S Takahashi, S Lee, RM Coates, ... Plant physiology 138 (3), 1322-1333, 2005 | 36 | 2005 |
Sesquiterpene synthase gene and protein J Chappell, B Greenhagen US Patent 7,442,785, 2008 | 35* | 2008 |
Probing sesquiterpene hydroxylase activities in a coupled assay with terpene synthases BT Greenhagen, P Griggs, S Takahashi, L Ralston, J Chappell Archives of Biochemistry and Biophysics 409 (2), 385-394, 2003 | 24 | 2003 |
Gene library synthesis by structure-based combinatorial protein engineering PE O'Maille, MD Tsai, BT Greenhagen, J Chappell, JP Noel Methods in enzymology 388, 75-91, 2004 | 20 | 2004 |
Methods for Splicing Plant Genes J Chappell, M Schoenbeck, B Greenhagen US Patent App. 11/610,733, 2007 | 10 | 2007 |
Origins of isoprenoid diversity: A study of structure-function relationships in sesquiterpene synthases BT Greenhagen University of Kentucky, 2003 | 9 | 2003 |
Chapter ten The chemical wizardry of isoprenoid metabolism in plants BT Greenhagen, MA Schoenbeck, YS Yeo, J Chappell Recent Advances in Phytochemistry 37, 231-251, 2003 | 4 | 2003 |
Unraveling the catalytic specificity of terpene biosynthetic enzymes and engineering the biosynthesis of novel terpenes in yeast and plants J Chappell, S Wu, S Takahashi, B Greenhagen In Vitro Cellular & Developmental Biology-Animal 44, S27-S27, 2008 | 3 | 2008 |
Engineering terpene synthases for novel product specificity BT Greenhagen, YX Zhao, P O'Maille, J Noel, RM Coates, J Chappell FASEB JOURNAL 17 (5), A978-A978, 2003 | | 2003 |
Dissecting the chemical wizardry of terpene synthases BT Greenhagen, J Chappell FASEB JOURNAL 16 (5), A896-A896, 2002 | | 2002 |