On the existence and functionality of topologically associating domains JA Beagan, JE Phillips-Cremins Nature genetics 52 (1), 8-16, 2020 | 313 | 2020 |
YY1 and CTCF orchestrate a 3D chromatin looping switch during early neural lineage commitment JA Beagan, MT Duong, KR Titus, L Zhou, Z Cao, J Ma, CV Lachanski, ... Genome research 27 (7), 1139-1152, 2017 | 279 | 2017 |
Disease-associated short tandem repeats co-localize with chromatin domain boundaries JH Sun, L Zhou, DJ Emerson, SA Phyo, KR Titus, W Gong, TG Gilgenast, ... Cell 175 (1), 224-238. e15, 2018 | 192 | 2018 |
Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons EM Rocha, GA Smith, E Park, H Cao, E Brown, MA Hayes, J Beagan, ... Neurobiology of disease 82, 495-503, 2015 | 164 | 2015 |
Sustained systemic glucocerebrosidase inhibition induces brain α-synuclein aggregation, microglia and complement C1q activation in mice EM Rocha, GA Smith, E Park, H Cao, AR Graham, E Brown, JR McLean, ... Antioxidants & redox signaling 23 (6), 550-564, 2015 | 141 | 2015 |
Local genome topology can exhibit an incompletely rewired 3D-folding state during somatic cell reprogramming JA Beagan, TG Gilgenast, J Kim, Z Plona, HK Norton, G Hu, SC Hsu, ... Cell stem cell 18 (5), 611-624, 2016 | 127 | 2016 |
Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression JA Beagan, ED Pastuzyn, LR Fernandez, MH Guo, K Feng, KR Titus, ... Nature neuroscience 23 (6), 707-717, 2020 | 125 | 2020 |
LADL: light-activated dynamic looping for endogenous gene expression control JH Kim, M Rege, J Valeri, MC Dunagin, A Metzger, KR Titus, TG Gilgenast, ... Nature methods 16 (7), 633-639, 2019 | 123 | 2019 |
Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection JR McLean, GA Smith, EM Rocha, MA Hayes, JA Beagan, PJ Hallett, ... Neuroscience letters 576, 73-78, 2014 | 103 | 2014 |
A Nurr1 agonist causes neuroprotection in a Parkinson’s disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly (I: C) GA Smith, EM Rocha, T Rooney, P Barneoud, JR McLean, J Beagan, ... PloS one 10 (3), e0121072, 2015 | 84 | 2015 |
Cohesin-dependence of neuronal gene expression relates to chromatin loop length L Calderon, FD Weiss, JA Beagan, MS Oliveira, R Georgieva, YF Wang, ... Elife 11, e76539, 2022 | 55* | 2022 |
5C-ID: Increased resolution Chromosome-Conformation-Capture-Carbon-Copy with in situ 3C and double alternating primer design JH Kim, KR Titus, W Gong, JA Beagan, Z Cao, JE Phillips-Cremins Methods 142, 39-46, 2018 | 21 | 2018 |
Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice DY Kwon, B Xu, P Hu, YT Zhao, JA Beagan, JH Nofziger, Y Cui, ... Nature communications 13 (1), 55, 2022 | 18 | 2022 |
ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress JR McLean, GA Smith, EM Rocha, TM Osborn, S Dib, MA Hayes, ... Experimental Neurology 261, 217-229, 2014 | 15 | 2014 |
Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression TM Osborn, J Beagan, O Isacson Neurobiology of Disease 110, 218-230, 2018 | 13 | 2018 |
CRISPR/Cas9 genome editing throws descriptive 3‐D genome folding studies for a loop JA Beagan, JE Phillips‐Cremins Wiley Interdisciplinary Reviews: Systems Biology and Medicine 8 (4), 286-299, 2016 | 4 | 2016 |
Stress-induced epigenetic regulation of transcription in neocortical excitatory neurons drives depression-like behavior DY Kwon, P Hu, YT Zhao, JA Beagan, JH Nofziger, Y Cui, B Xu, ... bioRxiv, 2020.07. 06.190280, 2020 | 2 | 2020 |
Elucidating the Regulatory Role of 3D Genome Folding During Neural Differentiation and Synaptic Activation JA Beagan University of Pennsylvania, 2020 | | 2020 |
Rab1A and Rab3B gene therapy in the Q175 knock in model of Huntington's disease GA Smith, EN Mangano, M Hayes, JR McLean, J Beagan, SC Izen, ... NEUROREPORT 25 (3), 149-149, 2014 | | 2014 |
Involvement of Rab Proteins in Corticostriatal Synaptic Function in the Q175 Knock in Model of Huntington's Disease GA Smith, EN Mangano, M Hayes, J Beagan, T Brand, SC Izen, TB Brown, ... CELL TRANSPLANTATION 22 (5), 916-917, 2013 | | 2013 |