Transcriptome and genome sequencing uncovers functional variation in humans T Lappalainen, M Sammeth, MR Friedländer, PAC ‘t Hoen, J Monlong, ... Nature 501 (7468), 506-511, 2013 | 2066 | 2013 |
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression U Võsa, A Claringbould, HJ Westra, MJ Bonder, P Deelen, B Zeng, ... Nature genetics 53 (9), 1300-1310, 2021 | 811 | 2021 |
Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis U Võsa, A Claringbould, HJ Westra, MJ Bonder, P Deelen, B Zeng, ... BioRxiv, 447367, 2018 | 494 | 2018 |
Disease variants alter transcription factor levels and methylation of their binding sites MJ Bonder, R Luijk, DV Zhernakova, M Moed, P Deelen, M Vermaat, ... Nature genetics 49 (1), 131-138, 2017 | 458 | 2017 |
Identification of context-dependent expression quantitative trait loci in whole blood DV Zhernakova, P Deelen, M Vermaat, M Van Iterson, M Van Galen, ... Nature genetics 49 (1), 139-145, 2017 | 440 | 2017 |
Extensive localization of long noncoding RNAs to the cytosol and mono-and polyribosomal complexes S van Heesch, M van Iterson, J Jacobi, S Boymans, PB Essers, ... Genome biology 15, 1-12, 2014 | 385 | 2014 |
Genetic and environmental influences interact with age and sex in shaping the human methylome J Van Dongen, MG Nivard, G Willemsen, JJ Hottenga, Q Helmer, ... Nature communications 7 (1), 11115, 2016 | 356 | 2016 |
Controlling bias and inflation in epigenome-and transcriptome-wide association studies using the empirical null distribution M van Iterson, EW van Zwet, Bios Consortium, BT Heijmans Genome biology 18, 1-13, 2017 | 295 | 2017 |
Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories PAC 't Hoen, MR Friedländer, J Almlöf, M Sammeth, I Pulyakhina, ... Nature biotechnology 31 (11), 1015-1022, 2013 | 270 | 2013 |
Blood lipids influence DNA methylation in circulating cells KF Dekkers, M van Iterson, RC Slieker, MH Moed, MJ Bonder, ... Genome biology 17, 1-12, 2016 | 193 | 2016 |
DNA methylation analysis identifies loci for blood pressure regulation MA Richard, T Huan, S Ligthart, R Gondalia, MA Jhun, JA Brody, MR Irvin, ... The American Journal of Human Genetics 101 (6), 888-902, 2017 | 178 | 2017 |
The effects of low levels of dystrophin on mouse muscle function and pathology M Van Putten, M Hulsker, VD Nadarajah, SH van Heiningen, ... PloS one 7 (2), e31937, 2012 | 174 | 2012 |
MethylAid: Visual and interactive quality control of large Illumina 450k data sets. M van Iterson, EW Tobi, RC Slieker, W den Hollander, R Luijk, ... Bioinformatics, 2014 | 168 | 2014 |
Improving phenotypic prediction by combining genetic and epigenetic associations S Shah, MJ Bonder, RE Marioni, Z Zhu, AF McRae, A Zhernakova, ... The American Journal of Human Genetics 97 (1), 75-85, 2015 | 153 | 2015 |
Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms RC Slieker, M van Iterson, R Luijk, M Beekman, DV Zhernakova, ... Genome biology 17, 1-13, 2016 | 136 | 2016 |
Relative power and sample size analysis on gene expression profiling data M van Iterson, PAC 't Hoen, P Pedotti, G Hooiveld, JT Den Dunnen, ... BMC genomics 10, 1-10, 2009 | 95 | 2009 |
Comparison of skeletal muscle pathology and motor function of dystrophin and utrophin deficient mouse strains M van Putten, D Kumar, M Hulsker, WMH Hoogaars, JJ Plomp, ... Neuromuscular disorders 22 (5), 406-417, 2012 | 90 | 2012 |
Single molecule sequencing of free DNA from maternal plasma for noninvasive trisomy 21 detection JME Van Den Oever, S Balkassmi, EJ Verweij, M Van Iterson, ... Clinical Chemistry 58 (4), 699-706, 2012 | 88 | 2012 |
Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs I Ricaño-Ponce, DV Zhernakova, P Deelen, O Luo, X Li, A Isaacs, ... Journal of autoimmunity 68, 62-74, 2016 | 85 | 2016 |
Filtering, FDR and power M van Iterson, JM Boer, RX Menezes BMC bioinformatics 11, 1-11, 2010 | 62 | 2010 |