Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target AN Kuntz, E Davioud-Charvet, AA Sayed, LL Califf, J Dessolin, ESJ Arnér, ... PLoS medicine 4 (6), e206, 2007 | 429 | 2007 |
Identification of oxadiazoles as new drug leads for the control of schistosomiasis AA Sayed, A Simeonov, CJ Thomas, J Inglese, CP Austin, DL Williams Nature medicine 14 (4), 407-412, 2008 | 318 | 2008 |
Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages S Donnelly, CM Stack, SM O'Neill, AA Sayed, DL Williams, JP Dalton The FASEB Journal 22 (11), 4022, 2008 | 271 | 2008 |
Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects F Angelucci, AA Sayed, DL Williams, G Boumis, M Brunori, ... Journal of Biological Chemistry 284 (42), 28977-28985, 2009 | 243 | 2009 |
A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa E Wilkinson, M Giovanetti, H Tegally, JE San, R Lessells, D Cuadros, ... Science 374 (6566), 423-431, 2021 | 198 | 2021 |
Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni AA Sayed, DL Williams Journal of Biological Chemistry 279 (25), 26159-26166, 2004 | 149 | 2004 |
Redox balance mechanisms in Schistosoma mansoni rely on peroxiredoxins and albumin and implicate peroxiredoxins as novel drug targets AA Sayed, SK Cook, DL Williams Journal of Biological Chemistry 281 (25), 17001-17010, 2006 | 137 | 2006 |
Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade A Simeonov, A Jadhav, AA Sayed, Y Wang, ME Nelson, CJ Thomas, ... PLoS Neglected Tropical Diseases 2 (1), e127, 2008 | 127 | 2008 |
Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis G Rai, AA Sayed, WA Lea, HF Luecke, H Chakrapani, S Prast-Nielsen, ... Journal of medicinal chemistry 52 (20), 6474-6483, 2009 | 99 | 2009 |
Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin HM Alger, AA Sayed, MJ Stadecker, DL Williams International Journal for Parasitology 32 (10), 1285-1292, 2002 | 94 | 2002 |
Isolation and characterization of a heavy metal-resistant, thermophilic esterase from a Red Sea Brine Pool YM Mohamed, MA Ghazy, A Sayed, A Ouf, H El-Dorry, R Siam Scientific reports 3 (1), 3358, 2013 | 89 | 2013 |
Profiling Schistosoma mansoni development using serial analysis of gene expression (SAGE) DL Williams, AA Sayed, J Bernier, SR Birkeland, MJ Cipriano, AR Papa, ... Experimental Parasitology 117 (3), 246-258, 2007 | 71 | 2007 |
A novel mercuric reductase from the unique deep brine environment of Atlantis II in the Red Sea A Sayed, MA Ghazy, AJS Ferreira, JC Setubal, FS Chambergo, A Ouf, ... Journal of Biological Chemistry 289 (3), 1675-1687, 2014 | 59 | 2014 |
Aerobic methanotrophic communities at the Red Sea brine-seawater interface RZ Abdallah, M Adel, A Ouf, A Sayed, MA Ghazy, I Alam, M Essack, ... Frontiers in microbiology 5, 487, 2014 | 45 | 2014 |
Biomphalaria glabrata peroxiredoxin: effect of Schistosoma mansoni infection on differential gene regulation M Knight, N Raghavan, C Goodall, C Cousin, W Ittiprasert, A Sayed, ... Molecular and biochemical parasitology 167 (1), 20-31, 2009 | 32 | 2009 |
Genetic Variants of Neurotransmitter‐Related Genes and miRNAs in Egyptian Autistic Patients AM Salem, S Ismail, WA Zarouk, O Abdul Baky, AA Sayed, ... The Scientific World Journal 2013 (1), 670621, 2013 | 29 | 2013 |
Whole genome sequencing of Klebsiella pneumoniae clinical isolates sequence type 627 isolated from Egyptian patients S Enany, S Zakeer, AA Diab, U Bakry, AA Sayed PloS one 17 (3), e0265884, 2022 | 28 | 2022 |
Core microbial functional activities in ocean environments revealed by global metagenomic profiling analyses AJS Ferreira, R Siam, JC Setubal, A Moustafa, A Sayed, FS Chambergo, ... PLoS One 9 (6), e97338, 2014 | 26 | 2014 |
A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase WA Lea, A Jadhav, G Rai, AA Sayed, CL Cass, J Inglese, DL Williams, ... Assay and drug development technologies 6 (4), 551-555, 2008 | 25 | 2008 |
Genotypic characterization of multiple drug resistant Escherichia coli isolates from a pediatric cancer hospital in Egypt R Hassan, M Tantawy, NA Gouda, MG Elzayat, S Gabra, A Nabih, ... Scientific reports 10 (1), 4165, 2020 | 23 | 2020 |