| Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment Y Sakurai, AA Kolokoltsov, CC Chen, MW Tidwell, WE Bauta, ... Science 347 (6225), 995-998, 2015 | 591 | 2015 |
| High susceptibility to fatty liver disease in two-pore channel 2-deficient mice C Grimm, LM Holdt, CC Chen, S Hassan, C Müller, S Jörs, H Cuny, ... Nature communications 5 (1), 4699, 2014 | 220 | 2014 |
| Expression of Ca2+‐permeable two‐pore channels rescues NAADP signalling in TPC‐deficient cells M Ruas, LC Davis, CC Chen, AJ Morgan, KT Chuang, TF Walseth, ... The EMBO journal 34 (13), 1743-1758, 2015 | 189 | 2015 |
| A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV CC Chen, M Keller, M Hess, R Schiffmann, N Urban, A Wolfgardt, ... Nature communications 5 (1), 4681, 2014 | 169 | 2014 |
| Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function S Gerndt, CC Chen, YK Chao, Y Yuan, S Burgstaller, A Scotto Rosato, ... Elife 9, e54712, 2020 | 146 | 2020 |
| Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells E Plesch, CC Chen, E Butz, A Scotto Rosato, EK Krogsaeter, H Yinan, ... Elife 7, e39720, 2018 | 92 | 2018 |
| Two-pore channels: catalyzers of endolysosomal transport and function C Grimm, CC Chen, C Wahl-Schott, M Biel Frontiers in pharmacology 8, 45, 2017 | 91 | 2017 |
| Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes CC Chen, C Cang, S Fenske, E Butz, YK Chao, M Biel, D Ren, ... Nature Protocols 12 (8), 1639-1658, 2017 | 90 | 2017 |
| From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease C Grimm, E Butz, CC Chen, C Wahl-Schott, M Biel Cell Calcium 67, 148-155, 2017 | 77 | 2017 |
| TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms YK Chao, V Schludi, CC Chen, E Butz, ONP Nguyen, M Müller, J Krüger, ... Proceedings of the National Academy of Sciences 114 (41), E8595-E8602, 2017 | 77 | 2017 |
| Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP X Zong, S Krause, CC Chen, J Krüger, C Gruner, X Cao-Ehlker, S Fenske, ... Journal of Biological Chemistry 287 (32), 26506-26512, 2012 | 76 | 2012 |
| BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action M Skasko, A Tokarev, CC Chen, WB Fischer, SK Pillai, J Guatelli Virology 411 (1), 65-77, 2011 | 75 | 2011 |
| ORF8a of SARS-CoV forms an ion channel: experiments and molecular dynamics simulations CC Chen, J Krüger, I Sramala, HJ Hsu, P Henklein, YMA Chen, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1808 (2), 572-579, 2011 | 67 | 2011 |
| Cellular zinc levels are modulated by TRPML1–TMEM163 interaction MP Cuajungco, LC Basilio, J Silva, T Hart, J Tringali, CC Chen, M Biel, ... Traffic 15 (11), 1247-1265, 2014 | 65 | 2014 |
| Small molecules for early endosome-specific patch clamping CC Chen, ES Butz, YK Chao, Y Grishchuk, L Becker, S Heller, ... Cell chemical biology 24 (7), 907-916. e4, 2017 | 48 | 2017 |
| Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth M Müller, S Gerndt, YK Chao, T Zisis, ONP Nguyen, A Gerwien, N Urban, ... Cell chemical biology 28 (8), 1119-1131. e27, 2021 | 47 | 2021 |
| Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice B Spix, ES Butz, CC Chen, AS Rosato, R Tang, A Jeridi, V Kudrina, ... Nature communications 13 (1), 318, 2022 | 44 | 2022 |
| Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2 P Netcharoensirisuk, C Abrahamian, R Tang, CC Chen, AS Rosato, ... Scientific Reports 11 (1), 8515, 2021 | 43 | 2021 |
| TRPML cation channels in inflammation and immunity B Spix, YK Chao, C Abrahamian, CC Chen, C Grimm Frontiers in immunology 11, 225, 2020 | 41 | 2020 |
| TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles CC Chen, E Krogsaeter, ES Butz, Y Li, R Puertollano, C Wahl-Schott, ... Science Advances 6 (46), eabb5064, 2020 | 35 | 2020 |
