| A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action E Campaner, A Rustighi, A Zannini, A Cristiani, S Piazza, Y Ciani, O Kalid, ... Nature communications 8 (1), 15772, 2017 | 139 | 2017 |
| Dihydroorotate dehydrogenase inhibitors in anti-infective drug research D Boschi, AC Pippione, S Sainas, ML Lolli European journal of medicinal chemistry 183, 111681, 2019 | 82 | 2019 |
| Use of human dihydroorotate dehydrogenase (hDHODH) inhibitors in autoimmune diseases and new perspectives in cancer therapy ML Lolli, S Sainas, AC Pippione, M Giorgis, D Boschi, F Dosio Recent Patents on Anti-Cancer Drug Discovery 13 (1), 86-105, 2018 | 77 | 2018 |
| Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors S Sainas, AC Pippione, E Lupino, M Giorgis, P Circosta, V Gaidano, ... Journal of medicinal chemistry 61 (14), 6034-6055, 2018 | 70 | 2018 |
| Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds S Sainas, AC Pippione, M Giorgis, E Lupino, P Goyal, C Ramondetti, ... European Journal of Medicinal Chemistry 129, 287-302, 2017 | 66 | 2017 |
| Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid AC Pippione, IM Carnovale, D Bonanni, M Sini, P Goyal, E Marini, K Pors, ... European Journal of Medicinal Chemistry 150, 930-945, 2018 | 58 | 2018 |
| Substituted 4-hydroxy-1, 2, 3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches AC Pippione, F Dosio, A Ducime, A Federico, K Martina, S Sainas, ... MedChemComm 6 (7), 1285-1292, 2015 | 58 | 2015 |
| Dopaminergic therapies modulate the T‐CELL proteome of patients with Parkinson's disease T Alberio, AC Pippione, C Comi, S Olgiati, D Cecconi, M Zibetti, L Lopiano, ... IUBMB life 64 (10), 846-852, 2012 | 46 | 2012 |
| Discovery and verification of panels of T-lymphocyte proteins as biomarkers of Parkinson's disease T Alberio, AC Pippione, M Zibetti, S Olgiati, D Cecconi, C Comi, L Lopiano, ... Scientific reports 2 (1), 953, 2012 | 44 | 2012 |
| Bioisosteres of indomethacin as inhibitors of aldo-keto reductase 1C3 ML Lolli, IM Carnovale, AC Pippione, WY Wahlgren, D Bonanni, E Marini, ... ACS medicinal chemistry letters 10 (4), 437-443, 2019 | 43 | 2019 |
| Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach AC Pippione, A Giraudo, D Bonanni, IM Carnovale, E Marini, C Cena, ... European Journal of Medicinal Chemistry 139, 936-946, 2017 | 43 | 2017 |
| Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies AC Pippione, S Sainas, P Goyal, I Fritzson, GC Cassiano, A Giraudo, ... European journal of medicinal chemistry 163, 266-280, 2019 | 37 | 2019 |
| N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK AC Pippione, S Sainas, A Federico, E Lupino, M Piccinini, M Kubbutat, ... MedChemComm 9 (6), 963-968, 2018 | 35 | 2018 |
| Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication A Luganini, G Sibille, B Mognetti, S Sainas, AC Pippione, M Giorgis, ... Antiviral Research 189, 105057, 2021 | 29 | 2021 |
| 4-Hydroxy-n-[3, 5-bis (trifluoromethyl) phenyl]-1, 2, 5-thiadiazole-3-carboxamide: A novel inhibitor of the canonical NF-κB cascade AC Pippione, A Federico, A Ducime, S Sainas, D Boschi, A Barge, ... MedChemComm 8 (9), 1850-1855, 2017 | 28 | 2017 |
| The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia V Gaidano, M Houshmand, N Vitale, G Carrà, A Morotti, V Tenace, ... Cancers 13 (5), 1003, 2021 | 27 | 2021 |
| Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold … S Sainas, M Giorgis, P Circosta, V Gaidano, D Bonanni, AC Pippione, ... Journal of Medicinal Chemistry 64 (9), 5404-5428, 2021 | 24 | 2021 |
| Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention AC Pippione, D Boschi, K Pors, S Oliaro-Bosso, ML Lolli Journal of Cancer Metastasis and Treatment 3 (12), 328-361, 2017 | 21 | 2017 |
| Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1, 2, 3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres S Sainas, AC Pippione, A Giraudo, K Martina, F Bosca, B Rolando, ... Journal of Heterocyclic Chemistry 56 (2), 501-519, 2019 | 18 | 2019 |
| AKR1C3 is a biomarker and druggable target for oropharyngeal tumors C Peraldo-Neia, P Ostano, M Mello-Grand, F Guana, I Gregnanin, ... Cellular Oncology 44, 357-372, 2021 | 16 | 2021 |
