| Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy NS Sharma, VK Gupta, VT Garrido, R Hadad, BC Durden, K Kesh, B Giri, ... The Journal of clinical investigation 130 (1), 451-465, 2020 | 178 | 2020 |
| Inactivation of cancer-associated-fibroblasts disrupts oncogenic signaling in pancreatic cancer cells and promotes its regression P Dauer, X Zhao, VK Gupta, N Sharma, K Kesh, P Gnamlin, V Dudeja, ... Cancer research 78 (5), 1321-1333, 2018 | 125 | 2018 |
| ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining “stemness” P Dauer, NS Sharma, VK Gupta, B Durden, R Hadad, S Banerjee, ... Cell death & disease 10 (2), 132, 2019 | 106 | 2019 |
| Therapy resistance, cancer stem cells and ECM in cancer: the matrix reloaded K Kesh, VK Gupta, B Durden, V Garrido, B Mateo-Victoriano, SP Lavania, ... Cancers 12 (10), 3067, 2020 | 69 | 2020 |
| O-GlcNAc modification of Sox2 regulates self-renewal in pancreatic cancer by promoting its stability NS Sharma, VK Gupta, P Dauer, K Kesh, R Hadad, B Giri, A Chandra, ... Theranostics 9 (12), 3410, 2019 | 65 | 2019 |
| Hypoxia-driven oncometabolite L-2HG maintains stemness-differentiation balance and facilitates immune evasion in pancreatic cancer VK Gupta, NS Sharma, B Durden, VT Garrido, K Kesh, D Edwards, ... Cancer research 81 (15), 4001-4013, 2021 | 61 | 2021 |
| Metastasis and chemoresistance in CD133 expressing pancreatic cancer cells are dependent on their lipid raft integrity VK Gupta, NS Sharma, K Kesh, P Dauer, A Nomura, B Giri, V Dudeja, ... Cancer letters 439, 101-112, 2018 | 58 | 2018 |
| NFκB-Mediated Invasiveness in CD133+ Pancreatic TICs Is Regulated by Autocrine and Paracrine Activation of IL1 Signaling A Nomura, VK Gupta, P Dauer, NS Sharma, V Dudeja, N Merchant, ... Molecular cancer research 16 (1), 162-172, 2018 | 58 | 2018 |
| Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells A Nomura, P Dauer, V Gupta, O McGinn, N Arora, K Majumdar, ... Oncotarget 7 (35), 56324, 2016 | 53 | 2016 |
| GRP 78‐mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells P Dauer, NS Sharma, VK Gupta, A Nomura, V Dudeja, A Saluja, ... Molecular oncology 12 (9), 1498-1512, 2018 | 48 | 2018 |
| Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer O McGinn, VK Gupta, P Dauer, N Arora, N Sharma, A Nomura, V Dudeja, ... Scientific reports 7 (1), 7872, 2017 | 40 | 2017 |
| Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer P Dauer, VK Gupta, O McGinn, A Nomura, NS Sharma, N Arora, B Giri, ... Scientific reports 7 (1), 1564, 2017 | 37 | 2017 |
| Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia B Giri, VK Gupta, B Yaffe, S Modi, P Roy, V Sethi, SP Lavania, SM Vickers, ... Journal of translational medicine 17, 1-9, 2019 | 35 | 2019 |
| Stroma secreted IL6 selects for “stem-like” population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways K Kesh, VT Garrido, A Dosch, B Durden, VK Gupta, NS Sharma, M Lyle, ... Cell death & disease 11 (11), 967, 2020 | 32 | 2020 |
| PE_PGRS30 of Mycobacterium tuberculosis mediates suppression of proinflammatory immune response in macrophages through its PGRS and PE domains S Chatrath, VK Gupta, A Dixit, LC Garg Microbes and Infection 18 (9), 536-542, 2016 | 31 | 2016 |
| Long non-coding RNA GAS5 acts as proliferation “brakes” in CD133+ cells responsible for tumor recurrence NS Sharma, P Gnamlin, B Durden, VK Gupta, K Kesh, VT Garrido, ... Oncogenesis 8 (12), 68, 2019 | 25 | 2019 |
| The Rv1651c-encoded PE-PGRS30 protein expressed in Mycobacterium smegmatis exhibits polar localization and modulates its growth profile S Chatrath, VK Gupta, A Dixit, LC Garg FEMS microbiology letters 322 (2), 194-199, 2011 | 23 | 2011 |
| Obesity enriches for tumor protective microbial metabolites and treatment refractory cells to confer therapy resistance in PDAC K Kesh, R Mendez, B Mateo-Victoriano, VT Garrido, B Durden, VK Gupta, ... Gut Microbes 14 (1), 2096328, 2022 | 17 | 2022 |
| Minnelide synergizes with conventional chemotherapy by targeting both cancer and associated stroma components in pancreatic cancer S Modi, B Giri, VK Gupta, S Lavania, V Sethi, NS Sharma, S Pandey, ... Cancer letters 537, 215591, 2022 | 16 | 2022 |
| The PGRS domain is responsible for translocation of PE_PGRS30 to cell poles while the PE and the C-terminal domains localize it to the cell wall S Chatrath, VK Gupta, LC Garg FEBS letters 588 (6), 990-994, 2014 | 15 | 2014 |
