关注
Justin Kale, Ph.D
Justin Kale, Ph.D
Research Associate, Sunnybrook Research Institute, Toronto
在 sri.utoronto.ca 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
BCL-2 family proteins: changing partners in the dance towards death
J Kale, EJ Osterlund, DW Andrews
Cell Death & Differentiation 25 (1), 65-80, 2018
14522018
Mechanisms of action of Bcl-2 family proteins
A Shamas-Din, J Kale, B Leber, DW Andrews
Cold Spring Harbor perspectives in biology 5 (4), a008714, 2013
8692013
Drugs targeting Bcl-2 family members as an emerging strategy in cancer
B Leber, F Geng, J Kale, DW Andrews
Expert reviews in molecular medicine 12, e28, 2010
1082010
BH 3‐in‐groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes
Z Zhang, S Subramaniam, J Kale, C Liao, B Huang, H Brahmbhatt, ...
The EMBO journal 35 (2), 208-236, 2016
1032016
Shedding light on apoptosis at subcellular membranes
J Kale, Q Liu, B Leber, DW Andrews
Cell 151 (6), 1179-1184, 2012
932012
Regulating cell death at, on, and in membranes
X Chi, J Kale, B Leber, DW Andrews
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (9), 2100-2113, 2014
892014
Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance
J Kale, O Kutuk, GC Brito, TS Andrews, B Leber, A Letai, DW Andrews
EMBO reports 19 (9), e45235, 2018
832018
After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial …
J Ding, BHM Mooers, Z Zhang, J Kale, D Falcone, J McNichol, B Huang, ...
Journal of Biological Chemistry 289 (17), 11873-11896, 2014
832014
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
N Rosa, H Ivanova, LE Wagner 2nd, J Kale, R La Rovere, ...
Cell Death & Differentiation 29 (4), 788-805, 2022
522022
Allosteric regulation of BH3 proteins in Bcl-xL complexes enables switch-like activation of Bax
C Bogner, J Kale, J Pogmore, X Chi, A Shamas-Din, C Fradin, B Leber, ...
Molecular Cell 77 (4), 901-912. e9, 2020
382020
Examining the molecular mechanism of bcl-2 family proteins at membranes by fluorescence spectroscopy
J Kale, X Chi, B Leber, D Andrews
Methods in Enzymology 544, 1-23, 2014
342014
Conformational heterogeneity of bax helix 9 dimer for apoptotic pore formation
C Liao, Z Zhang, J Kale, DW Andrews, J Lin, J Li
Scientific reports 6 (1), 29502, 2016
242016
Mechanisms of action of Bcl-2 family proteins. Cold Spring Harb Perspect Biol 5: a008714
A Shamas-Din, J Kale, B Leber, DW Andrews
242013
An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial␣ membrane
F Lv, F Qi, Z Zhang, M Wen, J Kale, A Piai, L Du, S Wang, L Zhou, Y Yang, ...
The EMBO journal 40 (14), e106438, 2021
232021
BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models
T Vervloessem, BK Sasi, E Xerxa, S Karamanou, J Kale, RM La Rovere, ...
Cell Death & Disease 11 (9), 769, 2020
222020
Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove
B Leber, J Kale, DW Andrews
Cancer discovery 8 (12), 1511-1514, 2018
42018
The C-terminal sequences of Bcl-2 family proteins mediate interactions that regulate cell death
D Nguyen, E Osterlund, J Kale, DW Andrews
Biochemical Journal 481 (14), 903-922, 2024
2024
Characterization of the Activation Mechanism of Bax
J Kale
2017
Multi-molecular complexes of Bcl-2 proteins regulate membrane permeabilization by Bax
C Bogner, J Kale, X Chi, B Leber, D Andrews
Oncology Research and Treatment 38, 99-100, 2015
2015
BH3-in-groove dimer interface that initiates mitochondrial Bax oligomerization rearranges to form a pore complex with an additional helix 9 dimer interface.
J Lin, Z Zhang, S Subramaniam, J Kale, A Senes, DW Andrews
MOLECULAR BIOLOGY OF THE CELL 25, 2014
2014
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