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Ana Isabel Moreno Manuel
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Molecular stratification of arrhythmogenic mechanisms in the Andersen Tawil syndrome
AI Moreno-Manuel, LK Gutiérrez, ML Vera-Pedrosa, FM Cruz, ...
Cardiovascular Research 119 (4), 919-932, 2023
132023
The Kir2. 1-NaV1. 5 Channelosome and its role in Arrhythmias in Inheritable Cardiac Diseases
LK Gutiérrez, AI Moreno-Manuel, J Jalife
Heart Rhythm, 2024
52024
Kir2. 1 dysfunction at the sarcolemma and the sarcoplasmic reticulum causes arrhythmias in a mouse model of Andersen–Tawil syndrome type 1
Á Macías, A González-Guerra, AI Moreno-Manuel, FM Cruz, LK Gutiérrez, ...
Nature Cardiovascular Research 1 (10), 900-917, 2022
52022
The Kir2.1E299V mutation increases atrial fibrillation vulnerability while protecting the ventricles against arrhythmias in a mouse model of short QT syndrome type 3
AI Moreno-Manuel, Á Macías, FM Cruz, LK Gutiérrez, F Martínez, ...
Cardiovascular Research 120 (5), 490-505, 2024
42024
Extracellular cysteine disulfide bond break at Cys122 disrupts PIP2-dependent Kir2. 1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome
FM Cruz, Á Macías, AI Moreno-Manuel, LK Gutiérrez, ML Vera-Pedrosa, ...
bioRxiv, 2023
22023
Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome
FM Cruz, Á Macías, AI Moreno-Manuel, LK Gutiérrez, ML Vera-Pedrosa, ...
Circulation Research 134 (8), e52-e71, 2024
12024
Dual dysfunction of Kir2. 1 underlies conduction and excitation-contraction coupling defects promoting arrhythmias in a mouse model of andersen-tawil syndrome type 1
A Macias, A González-Guerra, AI Moreno-Manuel, FM Cruz, ...
bioRxiv, 2021.06. 17.448833, 2021
12021
Short qt syndrome and sudden cardiac death due to a mutation in the tmem175 endolysosomal potassium channel
JJ Jáimez, F Bermúdez, A Moreno-Manuel, LGE de los Monteros, ...
Journal of the American College of Cardiology 75 (11_Supplement_1), 469-469, 2020
12020
Three dimensional modelling of mutant Kir2. 1 channel PIP2 interactions help stratify arrhythmia severity in Andersen Tawil syndrome type 1
L Gutierrez-Espinosa De Los Monteros, F Martinez, FM Cruz, ...
European Heart Journal 43 (Supplement_2), ehac544. 365, 2022
2022
Atrial-specific reduction of Kir2. 1 channel pore diameter in addition to loss of inward-going rectification underlies inducible atrial fibrillation in a mouse model of short …
A Moreno-Manuel, A Macias, FM Cruz, L Gutierrez, I Martinez Carrascoso, ...
European Heart Journal 43 (Supplement_2), ehac544. 2970, 2022
2022
B-AB18-02 KIR2. 1 CHANNELS IN A NOVEL SARCOPLASMIC RETICULUM MICRODOMAIN CONTROL INTRACELLULAR CA2+ DYNAMICS
A Macias, A González-Guerra, AI Moreno-Manuel, FM Cruz, ...
Elsevier, 2021
2021
Dual Dysfunction of Kir2. 1 at the Sarcolemma and the Sarcoplasmic Reticulum Underlies Arrhythmogenesis in a Mouse Model of the Andersen-Tawil Syndrome Type 1
A Macias, A González-Guerra, AI Moreno Manuel, FM Cruz Uréndez, ...
Circulation 142 (Suppl_3), A14836-A14836, 2020
2020
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