The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR RM Chin, X Fu, MY Pai, L Vergnes, H Hwang, G Deng, S Diep, ... Nature 510 (7505), 397-401, 2014 | 639 | 2014 |
2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling X Fu, RM Chin, L Vergnes, H Hwang, G Deng, Y Xing, MY Pai, S Li, L Ta, ... Cell metabolism 22 (3), 508-515, 2015 | 249 | 2015 |
Stimulation of hair growth by small molecules that activate autophagy M Chai, M Jiang, L Vergnes, X Fu, SC de Barros, NB Doan, W Huang, ... Cell reports 27 (12), 3413-3421. e3, 2019 | 99 | 2019 |
Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells X Fu, X Wu, MN Djekidel, Y Zhang Nature cell biology 21 (7), 835-844, 2019 | 93 | 2019 |
A transcriptional roadmap for 2C-like–to–pluripotent state transition X Fu, MN Djekidel, Y Zhang Science advances 6 (22), eaay5181, 2020 | 65 | 2020 |
Metabolic remodelling during early mouse embryo development J Zhao, K Yao, H Yu, L Zhang, Y Xu, L Chen, Z Sun, Y Zhu, C Zhang, ... Nature Metabolism 3 (10), 1372-1384, 2021 | 57 | 2021 |
Epigenetic regulation of mouse preimplantation embryo development X Fu, C Zhang, Y Zhang Current opinion in genetics & development 64, 13-20, 2020 | 39 | 2020 |
The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression C Zhang, Z Chen, Q Yin, X Fu, Y Li, T Stopka, AI Skoultchi, Y Zhang Genes & development 34 (3-4), 166-178, 2020 | 24 | 2020 |
Cell cycle heterogeneity directs spontaneous 2C state entry and exit in mouse embryonic stem cells Y Zhu, C Cheng, L Chen, L Zhang, H Pan, L Hou, Z Sun, L Zhang, X Fu, ... Stem Cell Reports 16 (11), 2659-2673, 2021 | 12 | 2021 |
M1 of murine gamma-herpesvirus 68 induces endoplasmic reticulum chaperone production J Feng, D Gong, X Fu, T Wu, J Wang, J Chang, J Zhou, G Lu, Y Wang, ... Scientific Reports 5 (1), 17228, 2015 | 6 | 2015 |
Simultaneous deep transcriptome and proteome profiling in a single mouse oocyte YR Jiang, L Zhu, LR Cao, Q Wu, JB Chen, Y Wang, J Wu, TY Zhang, ... Cell Reports 42 (11), 2023 | 4 | 2023 |
Simultaneous transcriptome and proteome profiling in a single mouse oocyte with a deep single-cell multi-omics approach YR Jiang, L Zhu, LR Cao, Q Wu, JB Chen, Y Wang, J Wu, TY Zhang, ... BioRxiv, 2022.08. 17.504335, 2022 | 4 | 2022 |
Zfp281 inhibits the pluripotent-to-totipotent state transition in mouse embryonic stem cells X Wen, Z Lin, H Wu, L Cao, X Fu Frontiers in Cell and Developmental Biology 10, 879428, 2022 | 4 | 2022 |
Ketobutyrate compounds and compositions for treating age-related symptoms and diseases J Huang, RM Chin, X Fu, H Hwang, K Reue, L Vergnes, M Jiang, ... US Patent 10,729,668, 2020 | 4 | 2020 |
Compositions and methods for treating aging and age-related diseases and symptoms J Huang, R Chin, S Diep, MY Pai, BE Lomenick, X Fu, K Reue, L Vergnes, ... US Patent App. 15/114,014, 2016 | 4 | 2016 |
Glutarate compounds for treating ischemia-reperfusion injuries J Huang, X Fu, X Yin, M Eghbali, J Li, K Reue, L Vergnes US Patent 10,285,962, 2019 | 2 | 2019 |
Mitophagy defect mediates the aging‐associated hallmarks in Hutchinson–Gilford progeria syndrome Y Sun, L Xu, Y Li, S Jia, G Wang, X Cen, Y Xu, Z Cao, J Wang, N Shen, ... Aging Cell 23 (6), e14143, 2024 | 1 | 2024 |
Glutarate compounds for treating ischemia-reperfusion injuries J Huang, X Fu, X Yin, M Eghbali, J Li, K Reue, L Vergnes US Patent 10,500,177, 2019 | 1 | 2019 |
Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms J Huang, RM Chin, S Diep, MY Pai, BE Lomenick, X Fu, KL Reue, ... US Patent App. 17/935,693, 2023 | | 2023 |
Prodrugs of alpha-ketoglutarate, alpha-ketobutyrate, alpha-ketoisovalerate, and alpha-ketoisohexanoate, and uses thereof ME Jung, J Huang, Y Xing, BE Lomenick, M Chai, X Fu US Patent App. 17/983,829, 2023 | | 2023 |