Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoid biosynthesis M Okada, Y Matsuda, T Mitsuhashi, S Hoshino, T Mori, K Nakagawa, ... Journal of the American Chemical Society 138 (31), 10011-10018, 2016 | 105 | 2016 |
A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis T Awakawa, L Zhang, T Wakimoto, S Hoshino, T Mori, T Ito, J Ishikawa, ... Journal of the American Chemical Society 136 (28), 9910-9913, 2014 | 85 | 2014 |
Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum Y Araki, T Awakawa, M Matsuzaki, R Cho, Y Matsuda, S Hoshino, ... Proceedings of the National Academy of Sciences 116 (17), 8269-8274, 2019 | 81 | 2019 |
Chojalactones A–C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium S Hoshino, T Wakimoto, H Onaka, I Abe Organic letters 17 (6), 1501-1504, 2015 | 81 | 2015 |
Niizalactams A–C, Multicyclic Macrolactams Isolated from Combined Culture of Streptomyces with Mycolic Acid-Containing Bacterium S Hoshino, M Okada, T Wakimoto, H Zhang, F Hayashi, H Onaka, I Abe Journal of natural products 78 (12), 3011-3017, 2015 | 79 | 2015 |
Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis Y Nakashima, T Mori, H Nakamura, T Awakawa, S Hoshino, M Senda, ... Nature communications 9 (1), 104, 2018 | 69 | 2018 |
Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria S Hoshino, H Onaka, I Abe Journal of Industrial Microbiology and Biotechnology 46 (3-4), 363-374, 2019 | 68 | 2019 |
Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823 S Hoshino, L Zhang, T Awakawa, T Wakimoto, H Onaka, I Abe The Journal of Antibiotics 68 (5), 342-344, 2015 | 65 | 2015 |
Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution T Awakawa, T Fujioka, L Zhang, S Hoshino, Z Hu, J Hashimoto, I Kozone, ... Nature communications 9 (1), 3534, 2018 | 62 | 2018 |
Structural basis for β-carboline alkaloid production by the microbial homodimeric enzyme McbB T Mori, S Hoshino, S Sahashi, T Wakimoto, T Matsui, H Morita, I Abe Chemistry & biology 22 (7), 898-906, 2015 | 59 | 2015 |
Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases T Mori, L Zhang, T Awakawa, S Hoshino, M Okada, H Morita, I Abe Nature communications 7 (1), 10849, 2016 | 57 | 2016 |
Crystalline sponge method enabled the investigation of a prenyltransferase-terpene synthase chimeric enzyme, whose product exhibits broadened NMR signals T Mitsuhashi, T Kikuchi, S Hoshino, M Ozeki, T Awakawa, SP Shi, M Fujita, ... Organic letters 20 (18), 5606-5609, 2018 | 56 | 2018 |
Mycolic acid containing bacterium stimulates tandem cyclization of polyene macrolactam in a lake sediment derived rare actinomycete S Hoshino, M Okada, T Awakawa, S Asamizu, H Onaka, I Abe Organic letters 19 (18), 4992-4995, 2017 | 49 | 2017 |
Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides R Kozakai, T Ono, S Hoshino, H Takahashi, Y Katsuyama, Y Sugai, ... Nature chemistry 12 (9), 869-877, 2020 | 47 | 2020 |
Molecular basis for the P450-catalyzed C–N bond formation in indolactam biosynthesis F He, T Mori, I Morita, H Nakamura, M Alblova, S Hoshino, T Awakawa, ... Nature Chemical Biology 15 (12), 1206-1213, 2019 | 43 | 2019 |
Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis T Mori, T Iwabuchi, S Hoshino, H Wang, Y Matsuda, I Abe Nature Chemical Biology 13 (10), 1066-1073, 2017 | 38 | 2017 |
Exploiting a C–N bond forming cytochrome P450 monooxygenase for C–S bond formation I Morita, T Mori, T Mitsuhashi, S Hoshino, Y Taniguchi, T Kikuchi, K Nagae, ... Angewandte Chemie International Edition 59 (10), 3988-3993, 2020 | 35 | 2020 |
Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium S Hoshino, CP Wong, M Ozeki, H Zhang, F Hayashi, T Awakawa, ... The Journal of antibiotics 71 (7), 653-657, 2018 | 35 | 2018 |
Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium S Hoshino, M Ozeki, T Awakawa, H Morita, H Onaka, I Abe Journal of Natural Products 81 (9), 2106-2110, 2018 | 33 | 2018 |
Mirilactams C–E, novel polycyclic macrolactams isolated from combined-culture of Actinosynnema mirum NBRC 14064 and mycolic acid-containing bacterium S Hoshino, M Ozeki, CP Wong, H Zhang, F Hayashi, T Awakawa, H Morita, ... Chemical and Pharmaceutical Bulletin 66 (6), 660-667, 2018 | 23 | 2018 |