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Kevin M Rattigan
Kevin M Rattigan
在 glasgow.ac.uk 的电子邮件经过验证
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Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli
KM Rattigan, AW Pountain, C Regnault, F Achcar, IM Vincent, ...
PloS one 13 (3), e0194126, 2018
472018
Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei
PC Steketee, IM Vincent, F Achcar, F Giordani, DH Kim, DJ Creek, ...
PLoS neglected tropical diseases 12 (5), e0006450, 2018
442018
The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion
LC Rodgers, J Cole, KM Rattigan, MP Barrett, N Kurian, IB McInnes, ...
Rheumatology 59 (4), 869-878, 2020
322020
ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy
A Ianniciello, MM Zarou, KM Rattigan, M Scott, A Dawson, K Dunn, ...
Science Translational Medicine 13 (613), eabd5016, 2021
292021
The ins and outs of autophagy and metabolism in hematopoietic and leukemic stem cells: food for thought
A Ianniciello, KM Rattigan, GV Helgason
Frontiers in cell and developmental biology 6, 120, 2018
252018
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
K Woodley, LS Dillingh, G Giotopoulos, P Madrigal, KM Rattigan, ...
Nature Communications 14 (1), 2132, 2023
102023
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
KM Rattigan, Z Brabcova, D Sarnello, MM Zarou, K Roy, R Kwan, ...
Nature communications 14 (1), 4634, 2023
82023
Metabolism in stem cell–driven leukemia: parallels between hematopoiesis and immunity
KM Rattigan, MM Zarou, GV Helgason
Blood, The Journal of the American Society of Hematology 141 (21), 2553-2565, 2023
72023
Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia
K Woodley, LS Dillingh, G Giotopoulos, P Madrigal, K Tzelepis, C Philippe, ...
Blood 138, 508, 2021
12021
Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia
A Khalaf, L de Beauchamp, E Kalkman, K Rattigan, E Himonas, J Jones, ...
Science Translational Medicine 16 (751), eadi5336, 2024
2024
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing
MM Zarou, KM Rattigan, D Sarnello, E Shokry, A Dawson, A Ianniciello, ...
Nature Communications 15 (1), 1931, 2024
2024
Mini review of metabolism in leukaemia: from complexity to the clinic
KM Rattigan
Frontiers in Hematology 2, 1353994, 2024
2024
Novel Role of Mitochondrial Folate Metabolism in Cell Fate Decisions and Leukaemogenesis
MM Zarou, K Rattigan, D Sarnello, A Dawson, K Dunn, M Copland, ...
Blood 142, 1369, 2023
2023
Nutrient-Sensitising Drug Repurposing Screen Identifies Lomerizine As a Mitochondrial Metabolism Inhibitor in Chronic Myeloid Leukaemia
A Khalaf, L de Beauchamp, E Kalkman, K Rattigan, E Himonas, J Jones, ...
Blood 142, 862, 2023
2023
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells
KM Rattigan, MM Zarou, Z Brabcova, B Prasad, D Zerbst, D Sarnello, ...
EMBO reports 24 (10), e56279, 2023
2023
Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing
MM Zarou, KM Rattigan, D Sarnello, A Dawson, A Ianniciello, K Dunn, ...
bioRxiv, 2022.12. 21.521404, 2022
2022
Metabolic profiling of myeloproliferative neoplasms reveals subtype specific metabolic traits
K Kirschner, K Rattigan, V Helgason, F Yan
Blood 140 (Supplement 1), 12180-12180, 2022
2022
Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death
K Woodley, LS Dillingh, G Giotopoulos, P Madrigal, KM Rattigan, ...
bioRxiv, 2022.05. 16.492042, 2022
2022
Inhibition of Folate Metabolism Drives Autophagy-Dependent Differentiation and Reduces Survival of Therapy-Resistant Leukaemic Stem Cells
MM Zarou, K Rattigan, Z Brabcova, A Dawson, D Sumpton, A Vazquez, ...
Blood 138, 2543, 2021
2021
P108/O28 Fatty acid oxidation can drive human monocyte derived CCL20 in the RA synovial environment
LC Rodgers, J Cole, K Rattigan, MP Barrett, N Kurian, IB McInnes, ...
Annals of the Rheumatic Diseases 78 (Suppl 1), A47-A48, 2019
2019
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