Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli KM Rattigan, AW Pountain, C Regnault, F Achcar, IM Vincent, ... PloS one 13 (3), e0194126, 2018 | 47 | 2018 |
Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei PC Steketee, IM Vincent, F Achcar, F Giordani, DH Kim, DJ Creek, ... PLoS neglected tropical diseases 12 (5), e0006450, 2018 | 44 | 2018 |
The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion LC Rodgers, J Cole, KM Rattigan, MP Barrett, N Kurian, IB McInnes, ... Rheumatology 59 (4), 869-878, 2020 | 32 | 2020 |
ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy A Ianniciello, MM Zarou, KM Rattigan, M Scott, A Dawson, K Dunn, ... Science Translational Medicine 13 (613), eabd5016, 2021 | 29 | 2021 |
The ins and outs of autophagy and metabolism in hematopoietic and leukemic stem cells: food for thought A Ianniciello, KM Rattigan, GV Helgason Frontiers in cell and developmental biology 6, 120, 2018 | 25 | 2018 |
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death K Woodley, LS Dillingh, G Giotopoulos, P Madrigal, KM Rattigan, ... Nature Communications 14 (1), 2132, 2023 | 10 | 2023 |
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells KM Rattigan, Z Brabcova, D Sarnello, MM Zarou, K Roy, R Kwan, ... Nature communications 14 (1), 4634, 2023 | 8 | 2023 |
Metabolism in stem cell–driven leukemia: parallels between hematopoiesis and immunity KM Rattigan, MM Zarou, GV Helgason Blood, The Journal of the American Society of Hematology 141 (21), 2553-2565, 2023 | 7 | 2023 |
Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia K Woodley, LS Dillingh, G Giotopoulos, P Madrigal, K Tzelepis, C Philippe, ... Blood 138, 508, 2021 | 1 | 2021 |
Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia A Khalaf, L de Beauchamp, E Kalkman, K Rattigan, E Himonas, J Jones, ... Science Translational Medicine 16 (751), eadi5336, 2024 | | 2024 |
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing MM Zarou, KM Rattigan, D Sarnello, E Shokry, A Dawson, A Ianniciello, ... Nature Communications 15 (1), 1931, 2024 | | 2024 |
Mini review of metabolism in leukaemia: from complexity to the clinic KM Rattigan Frontiers in Hematology 2, 1353994, 2024 | | 2024 |
Novel Role of Mitochondrial Folate Metabolism in Cell Fate Decisions and Leukaemogenesis MM Zarou, K Rattigan, D Sarnello, A Dawson, K Dunn, M Copland, ... Blood 142, 1369, 2023 | | 2023 |
Nutrient-Sensitising Drug Repurposing Screen Identifies Lomerizine As a Mitochondrial Metabolism Inhibitor in Chronic Myeloid Leukaemia A Khalaf, L de Beauchamp, E Kalkman, K Rattigan, E Himonas, J Jones, ... Blood 142, 862, 2023 | | 2023 |
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells KM Rattigan, MM Zarou, Z Brabcova, B Prasad, D Zerbst, D Sarnello, ... EMBO reports 24 (10), e56279, 2023 | | 2023 |
Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing MM Zarou, KM Rattigan, D Sarnello, A Dawson, A Ianniciello, K Dunn, ... bioRxiv, 2022.12. 21.521404, 2022 | | 2022 |
Metabolic profiling of myeloproliferative neoplasms reveals subtype specific metabolic traits K Kirschner, K Rattigan, V Helgason, F Yan Blood 140 (Supplement 1), 12180-12180, 2022 | | 2022 |
Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death K Woodley, LS Dillingh, G Giotopoulos, P Madrigal, KM Rattigan, ... bioRxiv, 2022.05. 16.492042, 2022 | | 2022 |
Inhibition of Folate Metabolism Drives Autophagy-Dependent Differentiation and Reduces Survival of Therapy-Resistant Leukaemic Stem Cells MM Zarou, K Rattigan, Z Brabcova, A Dawson, D Sumpton, A Vazquez, ... Blood 138, 2543, 2021 | | 2021 |
P108/O28 Fatty acid oxidation can drive human monocyte derived CCL20 in the RA synovial environment LC Rodgers, J Cole, K Rattigan, MP Barrett, N Kurian, IB McInnes, ... Annals of the Rheumatic Diseases 78 (Suppl 1), A47-A48, 2019 | | 2019 |